ID   OMH5_SCHPO              Reviewed;         421 AA.
AC   Q96WW1; O14452; Q9UTS1;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=O-glycoside alpha-1,2-mannosyltransferase homolog 5;
DE            EC=2.4.1.-;
GN   Name=omh5; ORFNames=pi016, SPBC32H8.08c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=10620777;
RX   DOI=10.1002/(sici)1097-0061(20000115)16:1<71::aid-yea505>3.0.co;2-5;
RA   Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K.,
RA   Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y.,
RA   Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.;
RT   "A 38 kb segment containing the cdc2 gene from the left arm of fission
RT   yeast chromosome II: sequence analysis and characterization of the genomic
RT   DNA and cDNAs encoded on the segment.";
RL   Yeast 16:71-80(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=19054127; DOI=10.1111/j.1567-1364.2008.00458.x;
RA   Ikeda Y., Ohashi T., Tanaka N., Takegawa K.;
RT   "Identification and characterization of a gene required for alpha1,2-
RT   mannose extension in the O-linked glycan synthesis pathway in
RT   Schizosaccharomyces pombe.";
RL   FEMS Yeast Res. 9:115-125(2009).
CC   -!- FUNCTION: Probable mannosyltransferase involved in O-glycosylation of
CC       cell wall and secreted proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 15 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA21393.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAA21395.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB004535; BAA21395.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AB004534; BAA21393.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; CU329671; CAC37498.2; -; Genomic_DNA.
DR   RefSeq; NP_595614.2; NM_001021509.2.
DR   AlphaFoldDB; Q96WW1; -.
DR   SMR; Q96WW1; -.
DR   BioGRID; 276758; 15.
DR   STRING; 4896.SPBC32H8.08c.1; -.
DR   CAZy; GT15; Glycosyltransferase Family 15.
DR   MaxQB; Q96WW1; -.
DR   PaxDb; Q96WW1; -.
DR   EnsemblFungi; SPBC32H8.08c.1; SPBC32H8.08c.1:pep; SPBC32H8.08c.
DR   GeneID; 2540226; -.
DR   KEGG; spo:SPBC32H8.08c; -.
DR   PomBase; SPBC32H8.08c; omh5.
DR   VEuPathDB; FungiDB:SPBC32H8.08c; -.
DR   eggNOG; KOG4472; Eukaryota.
DR   HOGENOM; CLU_024327_2_1_1; -.
DR   InParanoid; Q96WW1; -.
DR   OMA; YQHSTIQ; -.
DR   PhylomeDB; Q96WW1; -.
DR   PRO; PR:Q96WW1; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; ISS:PomBase.
DR   GO; GO:0000026; F:alpha-1,2-mannosyltransferase activity; ISM:PomBase.
DR   GO; GO:0000032; P:cell wall mannoprotein biosynthetic process; ISM:PomBase.
DR   GO; GO:0097502; P:mannosylation; IBA:GO_Central.
DR   GO; GO:0006487; P:protein N-linked glycosylation; IBA:GO_Central.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR002685; Glyco_trans_15.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR31121; PTHR31121; 1.
DR   Pfam; PF01793; Glyco_transf_15; 1.
DR   PIRSF; PIRSF018153; Glyco_trans_15; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Glycosyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..421
FT                   /note="O-glycoside alpha-1,2-mannosyltransferase homolog 5"
FT                   /id="PRO_0000357059"
FT   ACT_SITE        318
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   421 AA;  49918 MW;  EDC6B4370A70BAFC CRC64;
     MKRYDTLHVW KLIKLLICKF LLFHDFGTAL FTSLVKASML GFHNWRRTYW LYLKKLRPIN
     DTYDAPFAIG CKNVAYEASQ YPRMNATFMV LARNSDLDGV LSSMNSIERR FNRHFKYPYV
     FLNDEPFTTE FKKAVKDATD SSIQFGVLDD ELWNFPKDVD KDMIDESIAE QVGVVYANFP
     SYHKMCRFFS RNFYKHPLMQ QYEWYWRLEP EVTFSCDISY DPFYYMDKHN KVYGYVIAIK
     ELAKTVPNLF RYTVAHQKIS NLPTTDLWSF FLDKRYETRI KKLKEEQKDQ GYYVLPEPPL
     NRIDGQIYNL CHFWSNFEIA RLDFYNSKEY NEYVDALENA GGFWTERWGD APVHSLAVGL
     LLNRSQVHYF RDLGYQHSTI QHCGQEYGCN CDCPFNIPDY ETKPGSCINE WASVMGGFLD
     E