OMH6_SCHPO
ID OMH6_SCHPO Reviewed; 298 AA.
AC Q9P4X2;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=O-glycoside alpha-1,2-mannosyltransferase homolog 6;
DE EC=2.4.1.-;
GN Name=omh6; ORFNames=SPAC959.04c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=19054127; DOI=10.1111/j.1567-1364.2008.00458.x;
RA Ikeda Y., Ohashi T., Tanaka N., Takegawa K.;
RT "Identification and characterization of a gene required for alpha1,2-
RT mannose extension in the O-linked glycan synthesis pathway in
RT Schizosaccharomyces pombe.";
RL FEMS Yeast Res. 9:115-125(2009).
CC -!- FUNCTION: Probable mannosyltransferase involved in O-glycosylation of
CC cell wall and secreted proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 15 family.
CC {ECO:0000305}.
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DR EMBL; CU329670; CAB93011.1; -; Genomic_DNA.
DR RefSeq; NP_594171.1; NM_001019596.2.
DR AlphaFoldDB; Q9P4X2; -.
DR SMR; Q9P4X2; -.
DR BioGRID; 279892; 59.
DR STRING; 4896.SPAC959.04c.1; -.
DR CAZy; GT15; Glycosyltransferase Family 15.
DR MaxQB; Q9P4X2; -.
DR PaxDb; Q9P4X2; -.
DR EnsemblFungi; SPAC959.04c.1; SPAC959.04c.1:pep; SPAC959.04c.
DR GeneID; 2543472; -.
DR KEGG; spo:SPAC959.04c; -.
DR PomBase; SPAC959.04c; omh6.
DR VEuPathDB; FungiDB:SPAC959.04c; -.
DR eggNOG; KOG4472; Eukaryota.
DR HOGENOM; CLU_855703_0_0_1; -.
DR InParanoid; Q9P4X2; -.
DR OMA; RWTESDI; -.
DR PhylomeDB; Q9P4X2; -.
DR PRO; PR:Q9P4X2; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; ISS:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000026; F:alpha-1,2-mannosyltransferase activity; ISM:PomBase.
DR GO; GO:0000032; P:cell wall mannoprotein biosynthetic process; ISM:PomBase.
DR GO; GO:0097502; P:mannosylation; IBA:GO_Central.
DR GO; GO:0006487; P:protein N-linked glycosylation; IBA:GO_Central.
DR GO; GO:0006493; P:protein O-linked glycosylation; IBA:GO_Central.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR002685; Glyco_trans_15.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR31121; PTHR31121; 1.
DR Pfam; PF01793; Glyco_transf_15; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Glycosyltransferase; Nucleus; Reference proteome; Transferase.
FT CHAIN 1..298
FT /note="O-glycoside alpha-1,2-mannosyltransferase homolog 6"
FT /id="PRO_0000316588"
FT ACT_SITE 220
FT /note="Nucleophile"
FT /evidence="ECO:0000255"
SQ SEQUENCE 298 AA; 35275 MW; 4D0017108A88C3EB CRC64;
MYFLILFSSN AELGEVLRTM RSVEDRFNKR FHYPWTFYGM DEFTEYFMST TSTIASGHCE
YGTKGITYTN HLQFILTISY LVHWDLSQVK PLVENNRLYQ QRADALAQEN LSYVYSPLFH
SFQDWVVRSL LYHPQLEYDY VWRIEPGLKL VCEEKKDIFS TFKDSDIVFT NHVCERKHSG
IYAMEEAIEE YKILNTQGDF SNIWVYSNNY TYCKYWPFNE ILSLKQIRHN QTYTNLINYL
LGSGGTYYHR WTESDILSAA FGVLRARANH MESVGFFLND DVHYCPETIP YTGRCACL
