ID   A28_YLDV                Reviewed;         139 AA.
AC   Q9DHJ5;
DT   29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Envelope protein A28 homolog;
DE   AltName: Full=Protein 118;
GN   OrderedLocusNames=118L;
OS   Yaba-like disease virus (YLDV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Yatapoxvirus.
OX   NCBI_TaxID=132475;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=314293; Simiiformes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11277691; DOI=10.1006/viro.2000.0761;
RA   Lee H.-J., Essani K., Smith G.L.;
RT   "The genome sequence of Yaba-like disease virus, a yatapoxvirus.";
RL   Virology 281:170-192(2001).
CC   -!- FUNCTION: Envelope protein required for virus entry into host cell and
CC       for cell-cell fusion (syncytium formation). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type
CC       II membrane protein {ECO:0000305}. Note=Component of the intracellular
CC       mature virion (IMV) membrane. {ECO:0000250}.
CC   -!- PTM: Contains two intramolecular disulfide bonds. They are created by
CC       the viral disulfide bond formation pathway, a poxvirus-specific pathway
CC       that operates on the cytoplasmic side of the MV membranes (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae A28 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AJ293568; CAC21356.1; -; Genomic_DNA.
DR   RefSeq; NP_073503.1; NC_002642.1.
DR   GeneID; 918608; -.
DR   KEGG; vg:918608; -.
DR   Proteomes; UP000136581; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR007664; Poxvirus_A28.
DR   Pfam; PF04584; Pox_A28; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Fusion of virus membrane with host membrane; Late protein;
KW   Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix; Viral envelope protein;
KW   Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT   CHAIN           1..139
FT                   /note="Envelope protein A28 homolog"
FT                   /id="PRO_0000099303"
FT   TRANSMEM        1..21
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..139
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   139 AA;  16135 MW;  DB76BCB272B1397C CRC64;
     MNPSSVFLIV VATVAICLIV IQVYYIYENY DNIKEFNSTH SLLEYSKTIN VFSLDRRIYD
     PNDHVHDVKQ KWRCVNYDNN YVSVSIFGFK SDSGKNIKNF STVDDCIDYT FSKSTHSNIF
     NPCINEDKSK DCNFLKSVL