OMP1_COXBU
ID OMP1_COXBU Reviewed; 252 AA.
AC Q83EK8; Q841J3; Q841J4; Q8KQK0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Outer membrane protein P1;
DE Flags: Precursor;
GN Name=ompP1; OrderedLocusNames=CBU_0311;
OS Coxiella burnetii (strain RSA 493 / Nine Mile phase I).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC Coxiella.
OX NCBI_TaxID=227377;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-43 AND 188-199,
RP SUBCELLULAR LOCATION, SUBUNIT, AND ION CONDUCTANCE.
RC STRAIN=Kerns, Koka, RSA 493 / Nine Mile phase I, and Scurry;
RX PubMed=12438349; DOI=10.1128/iai.70.12.6741-6750.2002;
RA Varghees S., Kiss K., Frans G., Braha O., Samuel J.E.;
RT "Cloning and porin activity of the major outer membrane protein P1 from
RT Coxiella burnetii.";
RL Infect. Immun. 70:6741-6750(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Henzerling, and Xinqiao;
RA Wei W., Wen B.;
RT "Cloning and expression of major outer membrane protein P1 gene of Coxiella
RT burnetii in Escherichia coli.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RSA 493 / Nine Mile phase I;
RX PubMed=12704232; DOI=10.1073/pnas.0931379100;
RA Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C.,
RA Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T.,
RA Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M.,
RA Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E.,
RA Fraser C.M., Heidelberg J.F.;
RT "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).
RN [4]
RP BIOTECHNOLOGY.
RX PubMed=16481504; DOI=10.1196/annals.1355.021;
RA Li Q., Niu D., Wen B., Chen M., Qiu L., Zhang J.;
RT "Protective immunity against Q fever induced with a recombinant P1 antigen
RT fused with HspB of Coxiella burnetii.";
RL Ann. N. Y. Acad. Sci. 1063:130-142(2005).
CC -!- FUNCTION: Able to form a pore in lipid bilayers.
CC -!- SUBUNIT: May form trimers. {ECO:0000269|PubMed:12438349}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000269|PubMed:12438349}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:12438349}. Note=Outer membrane location shown for
CC Nine Mile phase I, but not that it actually spans the membrane.
CC -!- DEVELOPMENTAL STAGE: Found in the large cell variant (LCV) stage, very
CC little is present in the small cell variant (SCV) stage (at protein
CC level). LCVs are more metabolically active than SCVs.
CC -!- BIOTECHNOLOGY: Might be used for vaccine production.
CC {ECO:0000269|PubMed:16481504}.
CC -!- SIMILARITY: Belongs to the Coxiella porin P1 (CPP1) (TC 1.B.43) family.
CC {ECO:0000305}.
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DR EMBL; AY082614; AAM03442.1; -; Genomic_DNA.
DR EMBL; AY249912; AAP04426.1; -; Genomic_DNA.
DR EMBL; AY249911; AAP04425.1; -; Genomic_DNA.
DR EMBL; AE016828; AAO89868.2; -; Genomic_DNA.
DR RefSeq; NP_819354.2; NC_002971.3.
DR RefSeq; WP_010957496.1; NC_002971.4.
DR AlphaFoldDB; Q83EK8; -.
DR STRING; 227377.CBU_0311; -.
DR TCDB; 1.B.43.1.1; the coxiella porin p1 (cpp1) family.
DR EnsemblBacteria; AAO89868; AAO89868; CBU_0311.
DR GeneID; 1208193; -.
DR KEGG; cbu:CBU_0311; -.
DR PATRIC; fig|227377.7.peg.303; -.
DR eggNOG; COG3637; Bacteria.
DR HOGENOM; CLU_1238523_0_0_6; -.
DR OMA; HIMDAHS; -.
DR Proteomes; UP000002671; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR011250; OMP/PagP_b-brl.
DR SUPFAM; SSF56925; SSF56925; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Direct protein sequencing; Ion transport; Membrane;
KW Pharmaceutical; Porin; Reference proteome; Signal; Transmembrane;
KW Transmembrane beta strand; Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:12438349"
FT CHAIN 24..252
FT /note="Outer membrane protein P1"
FT /id="PRO_0000318560"
FT VARIANT 17
FT /note="L -> F (in strain: Henzerling)"
FT VARIANT 33
FT /note="M -> L (in strain: Henzerling)"
FT VARIANT 60
FT /note="N -> D (in strain: Kerns)"
FT VARIANT 78
FT /note="F -> S (in strain: Xinqiao)"
FT VARIANT 79
FT /note="G -> S (in strain: Kerns)"
FT VARIANT 115
FT /note="P -> S (in strain: Scurry)"
FT VARIANT 120..122
FT /note="NYS -> T (in strain: Kerns and Scurry)"
FT VARIANT 125
FT /note="T -> I (in strain: Xinqiao)"
FT VARIANT 127
FT /note="L -> T (in strain: Kerns)"
FT VARIANT 131
FT /note="L -> F (in strain: Xinqiao)"
FT VARIANT 136
FT /note="L -> I (in strain: Kerns)"
FT VARIANT 147..148
FT /note="VY -> DD (in strain: Kerns)"
FT VARIANT 151..152
FT /note="AG -> SE (in strain: Kerns)"
FT VARIANT 168..171
FT /note="VAVS -> GPVG (in strain: Kerns)"
FT VARIANT 172
FT /note="M -> I (in strain: Xinqiao)"
FT VARIANT 176
FT /note="L -> M (in strain: Kerns)"
FT VARIANT 222..223
FT /note="GT -> EA (in strain: Kerns and Scurry)"
FT VARIANT 228
FT /note="S -> L (in strain: Kerns and Scurry)"
FT CONFLICT 192
FT /note="N -> I (in Ref. 1; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 199
FT /note="Y -> D (in Ref. 1; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 252 AA; 26771 MW; 577ED12852666E18 CRC64;
METTTKLAIG VSALCCLASA AFAGGPDIPM IDMNGFHIGL GFGYKSYTYD QVGTVTVTTN
GGTVLSVLHP VSASITQFGP VGELGYTFAS DWWIAGVKAQ YQYDNVRSVH IMDAPLVGSN
YSYRTRLGSH LTAMLLAGIK VNEANAVYLE AGYSTVWGKT TLFGPGPVAV SMKNRLNGGI
AGIGWRHYFM NNVFLDLSYD YALYRSKSNS VTLSSATASA EGTAIGVSGT VQNPKRVAIN
GITATVNYLF NI
