ID   OMP2A_BRUA2             Reviewed;         321 AA.
AC   Q2YMY8;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Porin Omp2a;
DE   Flags: Precursor;
GN   Name=omp2a; OrderedLocusNames=BAB1_0659;
OS   Brucella abortus (strain 2308).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=359391;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2308;
RX   PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA   Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
CC   -!- FUNCTION: Forms passive diffusion pores that allow small molecular
CC       weight hydrophilic materials across the outer membrane.
CC       {ECO:0000250|UniProtKB:B2SAB9}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:B2SAB9}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:B2SAB9}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:B2SAB9}.
CC   -!- DOMAIN: Consists of 16-stranded beta-barrel sheets, with large surface-
CC       exposed loops, that form a transmembrane pore at the center of each
CC       barrel. The pore is partially ocluded by a peptide loop that folds into
CC       the pore lumen (By similarity). {ECO:0000250|UniProtKB:B2SAB9}.
CC   -!- MISCELLANEOUS: The pore formed by Omp2a is larger than the one formed
CC       by Omp2b. Omp2b pores have optimal permeability to allow growth and
CC       protection against harmful compounds. The larger pore formed by Omp2a
CC       may be advantageous for intracellular growth, when the bacterium is
CC       competing with the host cell for nutrients whose concentration is
CC       particularly low within the phagosome. {ECO:0000250|UniProtKB:B2SAB9}.
CC   -!- SIMILARITY: Belongs to the alphaproteobacteria porin family.
CC       {ECO:0000305}.
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DR   EMBL; AM040264; CAJ10615.1; -; Genomic_DNA.
DR   RefSeq; WP_002969883.1; NZ_KN046823.1.
DR   AlphaFoldDB; Q2YMY8; -.
DR   STRING; 359391.BAB1_0659; -.
DR   EnsemblBacteria; CAJ10615; CAJ10615; BAB1_0659.
DR   GeneID; 3787381; -.
DR   KEGG; bmf:BAB1_0659; -.
DR   PATRIC; fig|359391.11.peg.2973; -.
DR   HOGENOM; CLU_044836_0_0_5; -.
DR   OMA; NMRFTLR; -.
DR   PhylomeDB; Q2YMY8; -.
DR   Proteomes; UP000002719; Chromosome I.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003684; Porin_alphabac.
DR   Pfam; PF02530; Porin_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Reference proteome;
KW   Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..321
FT                   /note="Porin Omp2a"
FT                   /id="PRO_0000354007"
SQ   SEQUENCE   321 AA;  34535 MW;  255D624AB464A4A7 CRC64;
     MNIKSLLLGS AAALVAASGA QAADAIVAPE PEAVEYVRVC DAYGAGYFYI PGTETCLRVH
     GYVRYDVKGG DDVYSGTDRN GWDKGARFAL MFNTNSETEL GTLGTYTQLR FNYTSNNSRH
     DGQYGDFSDD RDVADGGVST GKIAYTFTGG NGFSAVIALE QGGEDVDNDY TIDGYMPHVV
     GGLKYAGGWG SIAGVVAYDS VIEEWATKVR GDVNITDRFS VWLQGAYSSA ATPNQNYGQW
     GGDWAVWGGA KFIAPEKATF NLQAAHDDWG KTAVTANVAY QLVPGFTITP EVSYTKFGGE
     WKDTVAEDNA WGGIVRFQRS F