ID   OMP2B_BRUAB             Reviewed;         362 AA.
AC   Q44619; Q57EA2; Q9KH75;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Porin Omp2b;
DE   Flags: Precursor;
GN   Name=omp2b; OrderedLocusNames=BruAb1_0657;
OS   Brucella abortus biovar 1 (strain 9-941).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=262698;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=biovar 5;
RX   PubMed=8573514; DOI=10.1099/00207713-46-1-329;
RA   Ficht T.A., Husseinen H.S., Derr J., Bearden S.W.;
RT   "Species-specific sequences at the omp2 locus of Brucella type strains.";
RL   Int. J. Syst. Bacteriol. 46:329-331(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION IN PERMEABILITY TO SUGAR.
RC   STRAIN=45/20;
RX   PubMed=11466287; DOI=10.1128/jb.183.16.4839-4847.2001;
RA   Paquet J.-Y., Diaz M.A., Genevrois S., Grayon M., Verger J.-M.,
RA   de Bolle X., Lakey J.H., Letesson J.-J., Cloeckaert A.;
RT   "Molecular, antigenic, and functional analyses of Omp2b porin size variants
RT   of Brucella spp.";
RL   J. Bacteriol. 183:4839-4847(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=9-941;
RX   PubMed=15805518; DOI=10.1128/jb.187.8.2715-2726.2005;
RA   Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z.,
RA   Li L.-L., Kapur V., Alt D.P., Olsen S.C.;
RT   "Completion of the genome sequence of Brucella abortus and comparison to
RT   the highly similar genomes of Brucella melitensis and Brucella suis.";
RL   J. Bacteriol. 187:2715-2726(2005).
CC   -!- FUNCTION: Forms passive diffusion pores that allow small molecular
CC       weight hydrophilic materials across the outer membrane.
CC       {ECO:0000269|PubMed:11466287}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250|UniProtKB:Q44665}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:Q44665}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q44665}.
CC   -!- DOMAIN: Consists of 16-stranded beta-barrel sheets, with large surface-
CC       exposed loops, that form a transmembrane pore at the center of each
CC       barrel. The pore is partially ocluded by a peptide loop that folds into
CC       the pore lumen. {ECO:0000250|UniProtKB:Q44665}.
CC   -!- MISCELLANEOUS: The pore formed by Omp2a is larger than the one formed
CC       by Omp2b. Omp2b pores have optimal permeability to allow growth and
CC       protection against harmful compounds. The larger pore formed by Omp2a
CC       may be advantageous for intracellular growth, when the bacterium is
CC       competing with the host cell for nutrients whose concentration is
CC       particularly low within the phagosome. {ECO:0000250|UniProtKB:Q44665}.
CC   -!- SIMILARITY: Belongs to the alphaproteobacteria porin family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA67784.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAX74032.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U26438; AAA67784.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AF268033; AAF80104.1; -; Genomic_DNA.
DR   EMBL; AE017223; AAX74032.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_002971512.1; NC_006932.1.
DR   AlphaFoldDB; Q44619; -.
DR   SMR; Q44619; -.
DR   EnsemblBacteria; AAX74032; AAX74032; BruAb1_0657.
DR   GeneID; 3788833; -.
DR   KEGG; bmb:BruAb1_0657; -.
DR   HOGENOM; CLU_044836_0_0_5; -.
DR   Proteomes; UP000000540; Chromosome I.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003684; Porin_alphabac.
DR   Pfam; PF02530; Porin_2; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..362
FT                   /note="Porin Omp2b"
FT                   /id="PRO_5000143209"
FT   VARIANT         200..212
FT                   /note="DNDGGYTGTTNYH -> EDVDNDYT (in strain: 45/20)"
FT   VARIANT         219
FT                   /note="D -> H (in strain: 45/20)"
SQ   SEQUENCE   362 AA;  38723 MW;  E4738BF34DB8615C CRC64;
     MNIKSLLLGS AAALVAASGA QAADAIVAPE PEAVEYVRVC DAYGAGYFYI PGTETCLRVH
     GYVRYDVKGG DDVYSGTDRN GWDKSARFAL RVSTGSETEL GTLKTFTELR FNYAANNSGV
     DGKYGNETSS GTVMEFAYIQ LGGLRVGIDE SEFHTFTGYL GDVINDDVIS AGSYRTGKIS
     YTFTGGNGFS AVIALEQGGD NDGGYTGTTN YHIDGYMPDV VGGLKYAGGW GSIAGVVAYD
     SVIEEWAAKV RGDVNITDQF SVWLQGAYSS AATPDQNYGQ WGGDWAVWGG LKYQATQKAA
     FNLQAAHDDW GKTAVTANVA YELVPGFTVT PEVSYTKFGG EWKNTVAEDN AWGGIVRFQR
     SF