OMP2B_BRUME
ID OMP2B_BRUME Reviewed; 362 AA.
AC Q8YG56; Q45311;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Porin Omp2b;
DE Flags: Precursor;
GN Name=omp2b; OrderedLocusNames=BMEI1305;
OS Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=224914;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=biovar 1;
RX PubMed=8573514; DOI=10.1099/00207713-46-1-329;
RA Ficht T.A., Husseinen H.S., Derr J., Bearden S.W.;
RT "Species-specific sequences at the omp2 locus of Brucella type strains.";
RL Int. J. Syst. Bacteriol. 46:329-331(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16M / ATCC 23456 / NCTC 10094;
RX PubMed=11756688; DOI=10.1073/pnas.221575398;
RA DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA Haselkorn R., Kyrpides N.C., Overbeek R.;
RT "The genome sequence of the facultative intracellular pathogen Brucella
RT melitensis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
RN [3]
RP FUNCTION IN PERMEABILITY TO SUGAR.
RC STRAIN=16M / ATCC 23456 / NCTC 10094;
RX PubMed=11466287; DOI=10.1128/jb.183.16.4839-4847.2001;
RA Paquet J.-Y., Diaz M.A., Genevrois S., Grayon M., Verger J.-M.,
RA de Bolle X., Lakey J.H., Letesson J.-J., Cloeckaert A.;
RT "Molecular, antigenic, and functional analyses of Omp2b porin size variants
RT of Brucella spp.";
RL J. Bacteriol. 183:4839-4847(2001).
CC -!- FUNCTION: Forms passive diffusion pores that allow small molecular
CC weight hydrophilic materials across the outer membrane.
CC {ECO:0000269|PubMed:11466287}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250|UniProtKB:Q44665}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- DOMAIN: Consists of 16-stranded beta-barrel sheets, with large surface-
CC exposed loops, that form a transmembrane pore at the center of each
CC barrel. The pore is partially ocluded by a peptide loop that folds into
CC the pore lumen. {ECO:0000250|UniProtKB:Q44665}.
CC -!- MISCELLANEOUS: The pore formed by Omp2a is larger than the one formed
CC by Omp2b. Omp2b pores have optimal permeability to allow growth and
CC protection against harmful compounds. The larger pore formed by Omp2a
CC may be advantageous for intracellular growth, when the bacterium is
CC competing with the host cell for nutrients whose concentration is
CC particularly low within the phagosome. {ECO:0000250|UniProtKB:Q44665}.
CC -!- SIMILARITY: Belongs to the alphaproteobacteria porin family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA67790.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL52486.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U26440; AAA67790.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE008917; AAL52486.1; ALT_INIT; Genomic_DNA.
DR PIR; AC3415; AC3415.
DR RefSeq; WP_006256196.1; NZ_GG703778.1.
DR AlphaFoldDB; Q8YG56; -.
DR SMR; Q8YG56; -.
DR STRING; 224914.BMEI1305; -.
DR EnsemblBacteria; AAL52486; AAL52486; BMEI1305.
DR GeneID; 29594147; -.
DR KEGG; bme:BMEI1305; -.
DR KEGG; bmel:DK63_100; -.
DR PATRIC; fig|224914.52.peg.103; -.
DR eggNOG; COG3203; Bacteria.
DR PhylomeDB; Q8YG56; -.
DR Proteomes; UP000000419; Chromosome I.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR003684; Porin_alphabac.
DR Pfam; PF02530; Porin_2; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW Transmembrane beta strand; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..362
FT /note="Porin Omp2b"
FT /id="PRO_0000354014"
FT VARIANT 55
FT /note="I -> T (in strain: biovar 1)"
SQ SEQUENCE 362 AA; 38705 MW; 058ADB9F1A95CE85 CRC64;
MNIKSLLLGS AAALVAASGA QAADAIVAPE PEAVEYVRVC DAYGAGYFYI PGTEICLRVH
GYVRYDVKGG DDVYSGTDRN GWDKGARFAL RVSTGSETEL GTLKTFTELR FNYAANNSGV
DGKYGNETSS GTVMEFAYIQ LGGLRVGIDE SEFHTFTGYL GDVINDDVIS AGSYRTGKIS
YTFTGGNGFS AVIALEQGGD NDGGYTGTTN YHIDGYMPDV VGGLKYAGGW GSIAGVVAYD
SVIEEWAAKV RGDVNITDQF SVWLQGAYSS AATPDQNYGQ WGGDWAVWGG LKYQATQKAA
FNLQAAHDDW GKTAVTANVA YELVPGFTVT PEVSYTKFGG EWKNTVAEDN AWGGIVRFQR
SF
