OMP2B_BRUOV
ID OMP2B_BRUOV Reviewed; 367 AA.
AC Q45330; A5HJR0; Q9KH73;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 25-MAY-2022, entry version 56.
DE RecName: Full=Porin Omp2b;
DE Flags: Precursor;
GN Name=omp2b;
OS Brucella ovis.
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=236;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8573514; DOI=10.1099/00207713-46-1-329;
RA Ficht T.A., Husseinen H.S., Derr J., Bearden S.W.;
RT "Species-specific sequences at the omp2 locus of Brucella type strains.";
RL Int. J. Syst. Bacteriol. 46:329-331(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION IN PERMEABILITY TO SUGAR.
RC STRAIN=76-250;
RX PubMed=11466287; DOI=10.1128/jb.183.16.4839-4847.2001;
RA Paquet J.-Y., Diaz M.A., Genevrois S., Grayon M., Verger J.-M.,
RA de Bolle X., Lakey J.H., Letesson J.-J., Cloeckaert A.;
RT "Molecular, antigenic, and functional analyses of Omp2b porin size variants
RT of Brucella spp.";
RL J. Bacteriol. 183:4839-4847(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=019;
RA Wenjun T., Chuangfu C., Yuanzhi W.;
RT "A new Brucella: Xinjiang Brucella ovis 019.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Forms passive diffusion pores that allow small molecular
CC weight hydrophilic materials across the outer membrane.
CC {ECO:0000269|PubMed:11466287}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250|UniProtKB:Q44665}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000250|UniProtKB:Q44665}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q44665}.
CC -!- DOMAIN: Consists of 16-stranded beta-barrel sheets, with large surface-
CC exposed loops, that form a transmembrane pore at the center of each
CC barrel. The pore is partially ocluded by a peptide loop that folds into
CC the pore lumen. {ECO:0000250|UniProtKB:Q44665}.
CC -!- MISCELLANEOUS: The pore formed by Omp2a is larger than the one formed
CC by Omp2b. Omp2b pores have optimal permeability to allow growth and
CC protection against harmful compounds. The larger pore formed by Omp2a
CC may be advantageous for intracellular growth, when the bacterium is
CC competing with the host cell for nutrients whose concentration is
CC particularly low within the phagosome. {ECO:0000250|UniProtKB:Q44665}.
CC -!- SIMILARITY: Belongs to the alphaproteobacteria porin family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA67796.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U26442; AAA67796.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF268035; AAF80106.1; -; Genomic_DNA.
DR EMBL; EF534310; ABP98814.1; -; Genomic_DNA.
DR AlphaFoldDB; Q45330; -.
DR SMR; Q45330; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR003684; Porin_alphabac.
DR Pfam; PF02530; Porin_2; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW Transmembrane beta strand; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..367
FT /note="Porin Omp2b"
FT /id="PRO_0000354019"
FT VARIANT 31
FT /note="P -> S (in strain: 019)"
FT VARIANT 59..60
FT /note="IS -> VH (in strain: 019)"
FT VARIANT 75..80
FT /note="TGSDRK -> SGTDRN (in strain: 019)"
FT VARIANT 85..95
FT /note="VLVLHSMFNTN -> GARFALRVSTG (in strain: 019)"
FT VARIANT 85..90
FT /note="VLVLHS -> GARFAL (in strain: 76-250)"
FT VARIANT 104..108
FT /note="GTYTT -> KTFTE (in strain: 019)"
FT VARIANT 114..115
FT /note="TS -> AA (in strain: 019)"
FT VARIANT 119..120
FT /note="RH -> GV (in strain: 019)"
FT VARIANT 123..145
FT /note="QYGDFSDDRDVADGSVSTGTDLQ -> KYGNETSSGTVME (in strain:
FT 019)"
FT VARIANT 150
FT /note="T -> Q (in strain: 019)"
FT VARIANT 154..155
FT /note="FK -> LR (in strain: 019)"
FT VARIANT 173
FT /note="I -> V (in strain: 019)"
FT VARIANT 190
FT /note="A -> S (in strain: 76-250)"
FT VARIANT 210..217
FT /note="EDVDNDYT -> DNDGGYTGTTNYH (in strain: 019 and 76-
FT 250)"
FT VARIANT 224
FT /note="H -> D (in strain: 019 and 76-250)"
FT VARIANT 253
FT /note="T -> A (in strain: 019 and 76-250)"
FT VARIANT 264
FT /note="R -> Q (in strain: 019 and 76-250)"
FT VARIANT 280
FT /note="N -> D (in strain: 019 and 76-250)"
FT VARIANT 362
FT /note="R -> H (in strain: 76-250)"
SQ SEQUENCE 367 AA; 39569 MW; 65803F00C87BEB6E CRC64;
MNIKSLLLGS AAALVAASGA QAADAIVAPE PEAVEYVRVC DAYGAGYFYI PGTETCLRIS
GYVRYDVKGG DDVYTGSDRK GWDKVLVLHS MFNTNSETEL GTLGTYTTLR FNYTSNNSRH
DGQYGDFSDD RDVADGSVST GTDLQFAYIT LGGFKVGIDE SEFHTFTGYL GDIINDDVIS
AGSYRTGKIA YTFTGGNGFS AVIALEQGGE DVDNDYTIDG YMPHVVGGLK YAGGWGSIAG
VVAYDSVIEE WATKVRGDVN ITDRFSVWLQ GAYSSAATPN QNYGQWGGDW AVWGGLKYQA
TQKAAFNLQA AHDDWGKTAV TANVAYELVP GFTVTPEVSY TKFGGEWKNT VAEDNAWGGI
VRFQRSF
