ARTN_RAT
ID ARTN_RAT Reviewed; 224 AA.
AC Q6AYE8; Q810F6; Q810F7; Q9QZG3;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Artemin;
DE Flags: Precursor;
GN Name=Artn;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-157 AND 184-224.
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RA Carmillo P., McAuliffe M., Tizard R., Cate R.L.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 68-192, AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Cochlea;
RX PubMed=10719212; DOI=10.1016/s0169-328x(99)00328-9;
RA Stoever T., Gong T.-W.L., Cho Y., Altschuler R.A., Lomax M.I.;
RT "Expression of the GDNF family members and their receptors in the mature
RT rat cochlea.";
RL Brain Res. Mol. Brain Res. 76:25-35(2000).
RN [4]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=9883723; DOI=10.1016/s0896-6273(00)80649-2;
RA Baloh R.H., Tansey M.G., Lampe P.A., Fahrner T.J., Enomoto H.,
RA Simburger K.S., Leitner M.L., Araki T., Johnson E.M. Jr., Milbrandt J.;
RT "Artemin, a novel member of the GDNF ligand family, supports peripheral and
RT central neurons and signals through the GFRalpha3-RET receptor complex.";
RL Neuron 21:1291-1302(1998).
CC -!- FUNCTION: Ligand for the GFR-alpha-3-RET receptor complex but can also
CC activate the GFR-alpha-1-RET receptor complex. Supports the survival of
CC sensory and sympathetic peripheral neurons in culture and also supports
CC the survival of dopaminergic neurons of the ventral mid-brain. Strong
CC attractant of gut hematopoietic cells thus promoting the formation
CC Peyer's patch-like structures, a major component of the gut-associated
CC lymphoid tissue (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Binds to RET (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Cochlea. Expressed at higher level in sesorineural
CC epithelium than in the modiolus region or substantia nigra.
CC {ECO:0000269|PubMed:10719212, ECO:0000269|PubMed:9883723}.
CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis. At embryonic day
CC 14 (E14) not detected in the brain or spinal cord. A striking
CC expression seen in the nerve roots but not in the developing neurons of
CC the dorsal root ganglia. A significant expression also seen around the
CC superior mesentric artery. {ECO:0000269|PubMed:9883723}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC {ECO:0000305}.
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DR EMBL; BC079078; AAH79078.1; -; mRNA.
DR EMBL; AY230412; AAO73543.1; -; mRNA.
DR EMBL; AY230413; AAO73544.1; -; mRNA.
DR EMBL; AF184919; AAF01241.1; -; mRNA.
DR RefSeq; NP_445849.1; NM_053397.1.
DR RefSeq; XP_006238747.1; XM_006238685.3.
DR RefSeq; XP_006238749.1; XM_006238687.3.
DR RefSeq; XP_017448983.1; XM_017593494.1.
DR AlphaFoldDB; Q6AYE8; -.
DR SMR; Q6AYE8; -.
DR STRING; 10116.ENSRNOP00000026852; -.
DR GlyGen; Q6AYE8; 1 site.
DR PaxDb; Q6AYE8; -.
DR Ensembl; ENSRNOT00000026852; ENSRNOP00000026852; ENSRNOG00000019842.
DR GeneID; 362572; -.
DR KEGG; rno:362572; -.
DR UCSC; RGD:621427; rat.
DR CTD; 9048; -.
DR RGD; 621427; Artn.
DR eggNOG; ENOG502S53F; Eukaryota.
DR GeneTree; ENSGT00950000182993; -.
DR HOGENOM; CLU_102221_0_0_1; -.
DR InParanoid; Q6AYE8; -.
DR OMA; VTQPCCR; -.
DR OrthoDB; 1373819at2759; -.
DR PhylomeDB; Q6AYE8; -.
DR TreeFam; TF332366; -.
DR Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
DR Reactome; R-RNO-8853659; RET signaling.
DR PRO; PR:Q6AYE8; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000019842; Expressed in stomach and 11 other tissues.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
DR GO; GO:0007411; P:axon guidance; ISO:RGD.
DR GO; GO:0050930; P:induction of positive chemotaxis; ISO:RGD.
DR GO; GO:0097021; P:lymphocyte migration into lymphoid organs; ISO:RGD.
DR GO; GO:0007422; P:peripheral nervous system development; IEP:RGD.
DR GO; GO:0061146; P:Peyer's patch morphogenesis; ISO:RGD.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR043401; GDNF_fam.
DR InterPro; IPR001839; TGF-b_C.
DR PANTHER; PTHR12173; PTHR12173; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Growth factor; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..39
FT /evidence="ECO:0000255"
FT PROPEP 40..111
FT /evidence="ECO:0000255"
FT /id="PRO_0000240290"
FT CHAIN 112..224
FT /note="Artemin"
FT /id="PRO_0000240291"
FT REGION 41..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..99
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 127..192
FT /evidence="ECO:0000250"
FT DISULFID 154..220
FT /evidence="ECO:0000250"
FT DISULFID 158..222
FT /evidence="ECO:0000250"
FT DISULFID 191
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT CONFLICT 174
FT /note="D -> G (in Ref. 3; AAF01241)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 224 AA; 23656 MW; 08907D743F651495 CRC64;
MELGLGEPTA LSHCLRPRWQ PALWPTLAAL ALLSSVTEAS LDPMSRSPAS RDVPSPVLAP
PTDYLPGGHT AHLCSERALR PPPQSPQPAP PPPGPALQSP PAALRGARAA RAGTRSSRAR
ATDARGCRLR SQLVPVSALG LGHSSDELIR FRFCSGSCRR ARSPHDLSLA SLLDAGALRS
PPGSRPISQP CCRPTRYEAV SFMDVNSTWR TVDHLSATAC GCLG
