ID   OMP38_ACIBT             Reviewed;         356 AA.
AC   A3M8K2;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Outer membrane protein Omp38;
DE   Flags: Precursor;
GN   Name=omp38; OrderedLocusNames=A1S_2840;
OS   Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC
OS   KC755 / 5377).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX   NCBI_TaxID=400667;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377;
RX   PubMed=17344419; DOI=10.1101/gad.1510307;
RA   Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N.,
RA   Gerstein M., Snyder M.;
RT   "New insights into Acinetobacter baumannii pathogenesis revealed by high-
RT   density pyrosequencing and transposon mutagenesis.";
RL   Genes Dev. 21:601-614(2007).
CC   -!- FUNCTION: Porin. Induces apoptosis in human cells through caspases-
CC       dependent and AIF-dependent pathways. Purified Omp38 enters the cells
CC       and localizes to the mitochondria, which leads to a release of
CC       proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing
CC       factor). {ECO:0000250|UniProtKB:Q6RYW5}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250|UniProtKB:Q6RYW5}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:Q6RYW5}; Multi-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000521; ABO13246.2; -; Genomic_DNA.
DR   RefSeq; WP_000777879.1; NZ_CP053098.1.
DR   AlphaFoldDB; A3M8K2; -.
DR   SMR; A3M8K2; -.
DR   KEGG; acb:A1S_2840; -.
DR   HOGENOM; CLU_031536_1_0_6; -.
DR   OMA; MYRINDA; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   CDD; cd07185; OmpA_C-like; 1.
DR   Gene3D; 3.30.1330.60; -; 1.
DR   InterPro; IPR011250; OMP/PagP_b-brl.
DR   InterPro; IPR027385; OMP_b-brl.
DR   InterPro; IPR006664; OMP_bac.
DR   InterPro; IPR006665; OmpA-like.
DR   InterPro; IPR036737; OmpA-like_sf.
DR   Pfam; PF13505; OMP_b-brl; 1.
DR   Pfam; PF00691; OmpA; 1.
DR   PRINTS; PR01021; OMPADOMAIN.
DR   SUPFAM; SSF103088; SSF103088; 1.
DR   SUPFAM; SSF56925; SSF56925; 1.
DR   PROSITE; PS51123; OMPA_2; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Cell outer membrane; Ion transport; Membrane; Porin; Signal;
KW   Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..356
FT                   /note="Outer membrane protein Omp38"
FT                   /id="PRO_0000290209"
FT   DOMAIN          221..339
FT                   /note="OmpA-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00473"
SQ   SEQUENCE   356 AA;  38450 MW;  F6E43F86B793642E CRC64;
     MKLSRIALAT MLVAAPLAAA NAGVTVTPLL LGYTFQDSQH NNGGKDGNLT NGPELQDDLF
     VGAALGIELT PWLGFEAEYN QVKGDVDGAS AGAEYKQKQI NGNFYVTSDL ITKNYDSKIK
     PYVLLGAGHY KYDFDGVNRG TRGTSEEGTL GNAGVGAFWR LNDALSLRTE ARATYNADEE
     FWNYTALAGL NVVLGGHLKP AAPVVEVAPV EPTPVTPQPQ ELTEDLNMEL RVFFDTNKSN
     IKDQYKPEIA KVAEKLSEYP NATARIEGHT DNTGPRKLNE RLSLARANSV KSALVNEYNV
     DASRLSTQGF AWDQPIADNK TKEGRAMNRR VFATITGSRT VVVQPGQEAA APAAAQ