OMP3_NEIGO
ID OMP3_NEIGO Reviewed; 236 AA.
AC P07050;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Outer membrane protein P.III;
DE AltName: Full=Gonococcal protein III;
DE Short=PIII;
DE Flags: Precursor;
OS Neisseria gonorrhoeae.
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=485;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3102671; DOI=10.1084/jem.165.2.471;
RA Gotschlich E.C., Seiff M., Blake M.S.;
RT "The DNA sequence of the structural gene of gonococcal protein III and the
RT flanking region containing a repetitive sequence. Homology of protein III
RT with enterobacterial OmpA proteins.";
RL J. Exp. Med. 165:471-482(1987).
CC -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: PIII is closely associated with part, but not all of the
CC PI molecules in the gonococcal outer membrane.
CC -!- MISCELLANEOUS: A portion of the PIII is exposed to the surface in
CC intact gonococci; the protein can be labeled with iodine and reacts
CC with MABs.
CC -!- SIMILARITY: Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
CC {ECO:0000305}.
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DR EMBL; X05105; CAA28752.1; -; Genomic_DNA.
DR PIR; A27894; A27894.
DR RefSeq; WP_003689500.1; NZ_WHPL01000002.1.
DR AlphaFoldDB; P07050; -.
DR SMR; P07050; -.
DR GeneID; 66753782; -.
DR OMA; CWRTGYW; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR CDD; cd07185; OmpA_C-like; 1.
DR Gene3D; 3.30.1330.60; -; 1.
DR InterPro; IPR006664; OMP_bac.
DR InterPro; IPR006665; OmpA-like.
DR InterPro; IPR006690; OMPA-like_CS.
DR InterPro; IPR036737; OmpA-like_sf.
DR Pfam; PF00691; OmpA; 1.
DR PRINTS; PR01021; OMPADOMAIN.
DR SUPFAM; SSF103088; SSF103088; 1.
DR PROSITE; PS01068; OMPA_1; 1.
DR PROSITE; PS51123; OMPA_2; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Disulfide bond; Ion transport; Membrane; Porin;
KW Repeat; Signal; Transmembrane; Transmembrane beta strand; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..236
FT /note="Outer membrane protein P.III"
FT /id="PRO_0000020110"
FT REPEAT 69..70
FT /note="1"
FT REPEAT 71..72
FT /note="2"
FT REPEAT 73..74
FT /note="3"
FT REPEAT 75..76
FT /note="4"
FT DOMAIN 86..223
FT /note="OmpA-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00473"
FT REGION 69..76
FT /note="4 X 2 AA tandem repeats of X-P"
FT DISULFID 185..208
FT /evidence="ECO:0000250"
SQ SEQUENCE 236 AA; 25540 MW; DAE9AAECA66FB199 CRC64;
MTKQLKLSAL FVALLASGTA VAGEASVQGY TVSGQSNEIV RNNYGECWKN AYFDKASQGR
VECGDAVAVP EPEPAPVAVV EQAPQYVDET ISLSAKTLFG FDKDSLRAEA QDNLKVLAQR
LSRTNVQSVR VEGHTDFMGS EKYNQALSER RAYVVANNLV SNGVPASRIS AVGLGESQAQ
MTQVCQAEVA KLGAKASKAK KREALIACIE PDRRVDVKIR SIVTRQVVPA RNHHQH