ID   OMP40_PORGI             Reviewed;         380 AA.
AC   Q9S3R8;
DT   17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Outer membrane protein 40;
DE            Short=Omp40;
DE   AltName: Full=PG33;
DE   Flags: Precursor;
GN   OrderedLocusNames=PG_0694;
OS   Porphyromonas gingivalis (strain ATCC BAA-308 / W83).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC   Porphyromonas.
OX   NCBI_TaxID=242619;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 53978 / W50;
RX   PubMed=11457538; DOI=10.1016/s0264-410x(01)00173-6;
RA   Ross B.C., Czajkowski L., Hocking D., Margetts M., Webb E., Rothel L.,
RA   Patterson M., Agius C., Camuglia S., Reynolds E.C., Littlejohn T.,
RA   Gaeta B., Ng A., Kuczek E.S., Mattick J.S., Gearing D.P., Barr I.G.;
RT   "Identification of vaccine candidate antigens from a genomic analysis of
RT   Porphyromonas gingivalis.";
RL   Vaccine 19:4135-4142(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-308 / W83;
RX   PubMed=12949112; DOI=10.1128/jb.185.18.5591-5601.2003;
RA   Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E.,
RA   Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L.,
RA   Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J.,
RA   Granger D., Tettelin H., Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E.,
RA   Fraser C.M.;
RT   "Complete genome sequence of the oral pathogenic bacterium Porphyromonas
RT   gingivalis strain W83.";
RL   J. Bacteriol. 185:5591-5601(2003).
RN   [3] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 22-380, AND PYROGLUTAMATE FORMATION AT GLN-22.
RC   STRAIN=ATCC 53978 / W50;
RX   PubMed=11532011; DOI=10.1046/j.1432-1327.2001.02399.x;
RA   Veith P.D., Talbo G.H., Slakeski N., Reynolds E.C.;
RT   "Identification of a novel heterodimeric outer membrane protein of
RT   Porphyromonas gingivalis by two-dimensional gel electrophoresis and peptide
RT   mass fingerprinting.";
RL   Eur. J. Biochem. 268:4748-4757(2001).
CC   -!- FUNCTION: May have porin activity and function in peptidoglycan
CC       binding. {ECO:0000303|PubMed:11532011}.
CC   -!- SUBUNIT: Disulfide-linked heterodimer with Omp41.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF175715; AAD51068.1; -; Genomic_DNA.
DR   EMBL; AE015924; AAQ65867.1; -; Genomic_DNA.
DR   RefSeq; WP_005873620.1; NC_002950.2.
DR   AlphaFoldDB; Q9S3R8; -.
DR   SMR; Q9S3R8; -.
DR   STRING; 242619.PG_0694; -.
DR   TCDB; 1.B.6.1.6; the ompa-ompf porin (oop) family.
DR   PRIDE; Q9S3R8; -.
DR   EnsemblBacteria; AAQ65867; AAQ65867; PG_0694.
DR   KEGG; pgi:PG_0694; -.
DR   eggNOG; COG2885; Bacteria.
DR   HOGENOM; CLU_058370_1_0_10; -.
DR   OMA; RITIEWK; -.
DR   OrthoDB; 583204at2; -.
DR   Proteomes; UP000000588; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019867; C:outer membrane; IDA:UniProtKB.
DR   GO; GO:0030247; F:polysaccharide binding; TAS:UniProtKB.
DR   GO; GO:0015288; F:porin activity; TAS:UniProtKB.
DR   CDD; cd07185; OmpA_C-like; 1.
DR   Gene3D; 3.30.1330.60; -; 1.
DR   InterPro; IPR006665; OmpA-like.
DR   InterPro; IPR006690; OMPA-like_CS.
DR   InterPro; IPR036737; OmpA-like_sf.
DR   Pfam; PF00691; OmpA; 1.
DR   SUPFAM; SSF103088; SSF103088; 1.
DR   PROSITE; PS01068; OMPA_1; 1.
DR   PROSITE; PS51123; OMPA_2; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Direct protein sequencing; Disulfide bond; Membrane;
KW   Pyrrolidone carboxylic acid; Reference proteome; Signal; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|PubMed:11532011"
FT   CHAIN           22..380
FT                   /note="Outer membrane protein 40"
FT                   /id="PRO_0000020113"
FT   DOMAIN          270..380
FT                   /note="OmpA-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00473"
FT   MOD_RES         22
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:11532011"
SQ   SEQUENCE   380 AA;  42452 MW;  6780199F89D75F4D CRC64;
     MKAKSLLLAL AGLACTFSAT AQEATTQNKA GMHTAFQRDK ASDHWFIDIA GGAGMALSGW
     NNDVDFVDRL SIVPTFGIGK WHEPYFGTRL QFTGFDIYGF PQGSKERNHN YFGNAHLDFM
     FDLTNYFGVY RPNRVFHIIP WAGIGFGYKF HSENANGEKV GSKDDMTGTV NVGLMLKFRL
     SRVVDFNIEG QAFAGKMNFI GTKRGKADFP VMATAGLTFN LGKTEWTEIV PMDYALVNDL
     NNQINSLRGQ VEELSRRPVS CPECPEPTQP TVTRVVVDNV VYFRINSAKI DRNQEINVYN
     TAEYAKTNNA PIKVVGYADE KTGTAAYNMK LSERRAKAVA KMLEKYGVSA DRITIEWKGS
     SEQIYEENAW NRIVVMTAAE