OMP52_HAEIF
ID OMP52_HAEIF Reviewed; 353 AA.
AC P38368;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Outer membrane protein P5 {ECO:0000303|PubMed:8359929};
DE Short=OMP P5;
DE AltName: Full=Outer membrane porin A {ECO:0000255|HAMAP-Rule:MF_00842};
DE AltName: Full=Outer membrane protein A;
DE Flags: Precursor;
GN Name=ompA {ECO:0000255|HAMAP-Rule:MF_00842};
GN Synonyms=ompP5 {ECO:0000303|PubMed:8359929};
OS Haemophilus influenzae.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=727;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 22-34.
RC STRAIN=1613 / Serotype B;
RX PubMed=8359929; DOI=10.1128/iai.61.9.4017-4020.1993;
RA Munson R.S. Jr., Grass S., West R.;
RT "Molecular cloning and sequence of the gene for outer membrane protein P5
RT of Haemophilus influenzae.";
RL Infect. Immun. 61:4017-4020(1993).
CC -!- FUNCTION: With TolR probably plays a role in maintaining the position
CC of the peptidoglycan cell wall in the periplasm. Acts as a porin with
CC low permeability that allows slow penetration of small solutes; an
CC internal gate slows down solute passage. {ECO:0000255|HAMAP-
CC Rule:MF_00842}.
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000255|HAMAP-Rule:MF_00842}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC Rule:MF_00842}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00842}.
CC -!- DOMAIN: The extracellular loops are most variable in sequence, and in
CC some bacteria confer sensitivity to phage and/or colicins.
CC {ECO:0000255|HAMAP-Rule:MF_00842}.
CC -!- MISCELLANEOUS: Non-typeable Haemophilus influenzae (NTHi) is a primary
CC pathogen in otitis media (inflammation of the middle ear).
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
CC OmpA family. {ECO:0000255|HAMAP-Rule:MF_00842}.
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DR EMBL; L20309; AAA03346.1; -; Unassigned_DNA.
DR RefSeq; WP_015702094.1; NZ_UEXC01000001.1.
DR AlphaFoldDB; P38368; -.
DR SMR; P38368; -.
DR PRIDE; P38368; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-UniRule.
DR GO; GO:0034220; P:ion transmembrane transport; IEA:UniProtKB-UniRule.
DR CDD; cd07185; OmpA_C-like; 1.
DR Gene3D; 3.30.1330.60; -; 1.
DR HAMAP; MF_00842; OmpA; 1.
DR InterPro; IPR011250; OMP/PagP_b-brl.
DR InterPro; IPR006664; OMP_bac.
DR InterPro; IPR002368; OmpA.
DR InterPro; IPR006665; OmpA-like.
DR InterPro; IPR006690; OMPA-like_CS.
DR InterPro; IPR036737; OmpA-like_sf.
DR InterPro; IPR000498; OmpA-like_TM_dom.
DR Pfam; PF00691; OmpA; 1.
DR Pfam; PF01389; OmpA_membrane; 1.
DR PRINTS; PR01021; OMPADOMAIN.
DR PRINTS; PR01022; OUTRMMBRANEA.
DR SUPFAM; SSF103088; SSF103088; 1.
DR SUPFAM; SSF56925; SSF56925; 1.
DR PROSITE; PS01068; OMPA_1; 1.
DR PROSITE; PS51123; OMPA_2; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Direct protein sequencing; Disulfide bond;
KW Ion transport; Membrane; Porin; Signal; Transmembrane;
KW Transmembrane beta strand; Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842,
FT ECO:0000269|PubMed:8359929"
FT CHAIN 22..353
FT /note="Outer membrane protein P5"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842"
FT /id="PRO_0000020108"
FT TRANSMEM 27..37
FT /note="Beta stranded"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842"
FT TRANSMEM 58..69
FT /note="Beta stranded"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842"
FT TRANSMEM 77..85
FT /note="Beta stranded"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842"
FT TRANSMEM 104..115
FT /note="Beta stranded"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842"
FT TRANSMEM 120..128
FT /note="Beta stranded"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842"
FT TRANSMEM 158..167
FT /note="Beta stranded"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842"
FT TRANSMEM 172..179
FT /note="Beta stranded"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842"
FT TRANSMEM 205..213
FT /note="Beta stranded"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842"
FT DOMAIN 227..353
FT /note="OmpA-like"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842"
FT SITE 80
FT /note="Part of salt bridge gating mechanism"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842"
FT SITE 175
FT /note="Part of salt bridge gating mechanism"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842"
FT DISULFID 326..338
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842"
SQ SEQUENCE 353 AA; 37594 MW; E58A659E7860D0F7 CRC64;
MKKTAIALVV AGLAAASVAQ AAPQENTFYA GVKAGQASFH DGLRALAREK NVGYHRNSFT
YGVFGGYQIL NQNNLGLAVE LGYDDFGRAK GREKGKTVAK HTNHGAHLSL KGSYEVLDGL
DVYGKAGVAL VRSDYKFYED ANGTRDHKKG RHTARASGLF AVGAEYAVLP ELAVRLEYQW
LTRVGKYRPQ DKPNTAINYN PWIGSINAGI SYRFGQGAAP VVAAPEVVSK TFSLNSDVTF
AFGKANLKPQ AQATLDSIYG EMSQVKSAKV AVAGYTDRIG SDAFNVKLSQ ERADSVANYF
VAKGVAADAI SATGYGKANP VTGATCDQVK GRKALIACLA PDRRVEIAVN GTK
