ID   OMPA2_NEIMC             Reviewed;         387 AA.
AC   P18194;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Major outer membrane protein P.IA;
DE            Short=PIA;
DE            Short=Protein IA;
DE   AltName: Full=Class 1 protein;
DE   Flags: Precursor;
GN   Name=porA;
OS   Neisseria meningitidis serogroup C.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=135720;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MC51 / Serogroup C / Type NT / Subtype 15;
RX   PubMed=1693651; DOI=10.1084/jem.171.6.1871;
RA   McGuinnes B., Barlow A.K., Clarke I.N., Farley J.E., Anilionis A.,
RA   Poolman J.T., Heckels J.E.;
RT   "Deduced amino acid sequences of class 1 protein (PorA) from three strains
RT   of Neisseria meningitidis. Synthetic peptides define the epitopes
RT   responsible for serosubtype specificity.";
RL   J. Exp. Med. 171:1871-1882(1990).
CC   -!- FUNCTION: Serves as a slightly cation selective porin. Major antigen on
CC       the gonococcal cell surface and it may have pathogenic properties in
CC       addition to its porin activity.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR   EMBL; X52996; CAA37185.1; -; Genomic_DNA.
DR   PIR; S11717; MMNH1.
DR   AlphaFoldDB; P18194; -.
DR   SMR; P18194; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   CDD; cd00342; gram_neg_porins; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR033900; Gram_neg_porin_domain.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   InterPro; IPR013793; Porin_Gram-ve_CS.
DR   InterPro; IPR002299; Porin_Neis.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00182; ECOLNEIPORIN.
DR   PRINTS; PR00184; NEISSPPORIN.
DR   PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..19
FT   CHAIN           20..387
FT                   /note="Major outer membrane protein P.IA"
FT                   /id="PRO_0000025276"
SQ   SEQUENCE   387 AA;  41777 MW;  B2CF8210260CBE4C CRC64;
     MRKKLTALVL SALPLAAVAD VSLYGEIKAG VEGRNFQLQL TEPPSKSQPQ VKVTKAKSRI
     RTKISDFGSF IGFKGSEDLG EGLKAVWQLE QDVSVAGGGA TQWGNRESFV GLAGEFGTLR
     AGRVANQFDD ASQAIDPWDS NNDVASQLGI FKRHDDMPVS VRYDSPDFSG FSGSVQFVPI
     QNSKSAYTPA HYTRQNNTDV FVPAVVGKPG SDVYYAGLNY KNGGFAGSYA FKYARHANVG
     RDAFELFLLG STSDEAKGTD PLKNHQVHRL TGGYEEGGLN LALAAQLDLS ENGDKAKTKN
     STTEIAATAS YRFGNAVPRI SYAHGFDLIE RGKKGENTSY DQIIAGVDYD FSKRTSAIVS
     GAWLKRNTGI GNYTQINAAS VGLRHKF