ID   OMPA_CITFR              Reviewed;         238 AA.
AC   P24016;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Outer membrane protein A {ECO:0000250|UniProtKB:P0A910};
DE   AltName: Full=Outer membrane porin A {ECO:0000250|UniProtKB:P0A910};
DE   AltName: Full=Outer membrane protein 3A {ECO:0000303|PubMed:1955870};
DE   Flags: Fragment;
GN   Name=ompA {ECO:0000250|UniProtKB:P0A910};
OS   Citrobacter freundii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter; Citrobacter freundii complex.
OX   NCBI_TaxID=546;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=OS60;
RX   PubMed=1955870; DOI=10.1099/00221287-137-8-1911;
RA   Lawrence J.G., Ochman H., Hartl D.L.;
RT   "Molecular and evolutionary relationships among enteric bacteria.";
RL   J. Gen. Microbiol. 137:1911-1921(1991).
CC   -!- FUNCTION: With TolR probably plays a role in maintaining the position
CC       of the peptidoglycan cell wall in the periplasm. Acts as a porin with
CC       low permeability that allows slow penetration of small solutes; an
CC       internal gate slows down solute passage.
CC       {ECO:0000250|UniProtKB:P0A910}.
CC   -!- SUBUNIT: Monomer and homodimer. {ECO:0000250|UniProtKB:P0A910}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P0A910}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P0A910}.
CC   -!- DOMAIN: The extracellular loops are most variable in sequence, and in
CC       some bacteria confer sensitivity to phage and/or colicins.
CC       {ECO:0000250|UniProtKB:P0A910}.
CC   -!- SIMILARITY: Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
CC       OmpA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M63354; AAA23095.1; -; Genomic_DNA.
DR   PIR; I40703; I40703.
DR   AlphaFoldDB; P24016; -.
DR   SMR; P24016; -.
DR   STRING; 1333848.CFNIH1_14820; -.
DR   PRIDE; P24016; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   CDD; cd07185; OmpA_C-like; 1.
DR   Gene3D; 3.30.1330.60; -; 1.
DR   InterPro; IPR011250; OMP/PagP_b-brl.
DR   InterPro; IPR006664; OMP_bac.
DR   InterPro; IPR002368; OmpA.
DR   InterPro; IPR006665; OmpA-like.
DR   InterPro; IPR006690; OMPA-like_CS.
DR   InterPro; IPR036737; OmpA-like_sf.
DR   InterPro; IPR000498; OmpA-like_TM_dom.
DR   Pfam; PF00691; OmpA; 1.
DR   Pfam; PF01389; OmpA_membrane; 1.
DR   PRINTS; PR01021; OMPADOMAIN.
DR   PRINTS; PR01022; OUTRMMBRANEA.
DR   SUPFAM; SSF103088; SSF103088; 1.
DR   SUPFAM; SSF56925; SSF56925; 1.
DR   PROSITE; PS01068; OMPA_1; 1.
DR   PROSITE; PS51123; OMPA_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Disulfide bond; Ion transport; Membrane; Porin;
KW   Repeat; Transmembrane; Transmembrane beta strand; Transport.
FT   CHAIN           <1..>238
FT                   /note="Outer membrane protein A"
FT                   /id="PRO_0000196252"
FT   TRANSMEM        <1..8
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250|UniProtKB:P0A910"
FT   TRANSMEM        13..21
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250|UniProtKB:P0A910"
FT   TRANSMEM        43..52
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250|UniProtKB:P0A910"
FT   TRANSMEM        57..64
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250|UniProtKB:P0A910"
FT   TRANSMEM        83..91
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250|UniProtKB:P0A910"
FT   REPEAT          104..105
FT                   /note="1"
FT   REPEAT          106..107
FT                   /note="2"
FT   REPEAT          108..109
FT                   /note="3"
FT   DOMAIN          111..>238
FT                   /note="OmpA-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00473"
FT   REGION          104..109
FT                   /note="3 X 2 AA tandem repeats of A-P"
FT   SITE            60
FT                   /note="Part of salt bridge gating mechanism"
FT                   /evidence="ECO:0000250|UniProtKB:P0A910"
FT   DISULFID        212..224
FT                   /evidence="ECO:0000250|UniProtKB:P0A910"
FT   NON_TER         1
FT   NON_TER         238
SQ   SEQUENCE   238 AA;  25664 MW;  66EA136D73A3F286 CRC64;
     LTAKLGYPIT DDLDIYTRLG GMVWRADAKN NEGFKDHDTG VSPVFAGGVE YAITPEIATR
     LEYQWTNNIG DANTVGGRPD NGLLSVGVSY RFGQQEEAAP VVVAPAPAPE VQTKHFTLKS
     DVLFNFNKAT LKPEGQQALD QMYSQLSNLD PKDGSVVVLG FTDRIGSDAY NQGLSEKRAQ
     SVVDYLISKG IPSDKISARG MGESNPVTGN TCDNVKARAA LIDCLAPDRR VEIEVKGI