ID   OMPA_NEIGO              Reviewed;         326 AA.
AC   P05430;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Major outer membrane protein P.IA;
DE            Short=PIA;
DE            Short=Protein IA;
DE   AltName: Full=Class 1 protein;
DE   Flags: Precursor;
GN   Name=porA;
OS   Neisseria gonorrhoeae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=FA19;
RX   PubMed=3122212; DOI=10.1073/pnas.84.24.9084;
RA   Carbonetti N.H., Sparling P.F.;
RT   "Molecular cloning and characterization of the structural gene for protein
RT   I, the major outer membrane protein of Neisseria gonorrhoeae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:9084-9088(1987).
CC   -!- FUNCTION: Serves as a slightly cation selective porin. Major antigen on
CC       the gonococcal cell surface and it may have pathogenic properties in
CC       addition to its porin activity.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR   EMBL; J03029; AAA25458.1; -; Genomic_DNA.
DR   PIR; A39951; A39951.
DR   AlphaFoldDB; P05430; -.
DR   SMR; P05430; -.
DR   TCDB; 1.B.1.5.1; the general bacterial porin (gbp) family.
DR   PRIDE; P05430; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   CDD; cd00342; gram_neg_porins; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR033900; Gram_neg_porin_domain.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   InterPro; IPR013793; Porin_Gram-ve_CS.
DR   InterPro; IPR002299; Porin_Neis.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00182; ECOLNEIPORIN.
DR   PRINTS; PR00184; NEISSPPORIN.
DR   PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..19
FT   CHAIN           20..326
FT                   /note="Major outer membrane protein P.IA"
FT                   /id="PRO_0000025272"
SQ   SEQUENCE   326 AA;  35684 MW;  3383C5CE4EEEF3DC CRC64;
     MKKSLIALTL AALPVAAMAD VTLYGTIKAG VETSRSVAHH GAQADRVKTA TEIADLGSKI
     GFKGQEDLGN GLKAIWQLEQ KAYVSGTDTG WGNRQSFIGL KGGFGKVRVG RLNSVLKDTG
     GFNPWEGKSY YLGLSNIAQP EERHVSVRYD SPEFAGFRAV QYVPNDNSGK NHSESYHAGF
     NYKNSGFFVQ YAGFYKRHSY TTEKHQVHRL VGGYDHDALY ASVAVQQQDA KLTWRNDNSH
     NSQTEVAATA AYRFGNVTPR VSYAHGFKGS VYDADNDNTY DQVVVGAEYD FSKRTSALVS
     AGWLQRGKGT EKFVATVGGV GLRHKF