ID   OMPA_NEIMA              Reviewed;         395 AA.
AC   P57041; A1ISL8;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Major outer membrane protein P.IA;
DE            Short=PIA;
DE            Short=Protein IA;
DE   AltName: Full=Class 1 protein;
DE   Flags: Precursor;
GN   Name=porA; OrderedLocusNames=NMA1642;
OS   Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS   Z2491).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10761919; DOI=10.1038/35006655;
RA   Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA   Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA   Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA   Barrell B.G.;
RT   "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT   Z2491.";
RL   Nature 404:502-506(2000).
CC   -!- FUNCTION: Serves as a slightly cation selective porin. Major antigen on
CC       the gonococcal cell surface and it may have pathogenic properties in
CC       addition to its porin activity.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR   EMBL; AL157959; CAM08777.1; -; Genomic_DNA.
DR   PIR; F81858; F81858.
DR   RefSeq; WP_002247001.1; NC_003116.1.
DR   PDB; 1QKZ; X-ray; 1.95 A; P=46-55.
DR   PDBsum; 1QKZ; -.
DR   AlphaFoldDB; P57041; -.
DR   SMR; P57041; -.
DR   ABCD; P57041; 1 sequenced antibody.
DR   EnsemblBacteria; CAM08777; CAM08777; NMA1642.
DR   KEGG; nma:NMA1642; -.
DR   HOGENOM; CLU_038238_4_0_4; -.
DR   OMA; GDKTKNS; -.
DR   BioCyc; NMEN122587:NMA_RS08205-MON; -.
DR   EvolutionaryTrace; P57041; -.
DR   Proteomes; UP000000626; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   CDD; cd00342; gram_neg_porins; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR033900; Gram_neg_porin_domain.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   InterPro; IPR013793; Porin_Gram-ve_CS.
DR   InterPro; IPR002299; Porin_Neis.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00182; ECOLNEIPORIN.
DR   PRINTS; PR00184; NEISSPPORIN.
DR   PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell outer membrane; Ion transport; Membrane; Porin; Signal;
KW   Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..395
FT                   /note="Major outer membrane protein P.IA"
FT                   /id="PRO_0000025273"
SQ   SEQUENCE   395 AA;  42270 MW;  F7D9CE6480586577 CRC64;
     MRKKLTALVL SALPLAAVAD VSLYGEIKAG VEGRNYQLQL TEAQAANGGA SGQVKVTKVT
     KAKSRIRTKI SDFGSFIGFK GSEDLGEGLK AVWQLEQDVS VAGGGATQWG NRESFIGLAG
     EFGTLRAGRV ANQFDDASQA IDPWDSNNDV ASQLGIFKRH DDMPVSVRYD SPEFSGFSGS
     VQFVPAQNSK SAYKPAYWTT VNTGSATTTT FVPAVVGKPG SDVYYAGLNY KNGGFAGNYA
     FKYARHANVG RDAFELFLLG SGSDQAKGTD PLKNHQVHRL TGGYEEGGLN LALAAQLDLS
     ENGDKTKNST TEIAATASYR FGNAVPRISY AHGFDFIERG KKGENTSYDQ IIAGVDYDFS
     KRTSAIVSGA WLKRNTGIGN YTQINAASVG LRHKF