ID   OMPA_NEIMH              Reviewed;         392 AA.
AC   E6MXW0; Q51240;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Major outer membrane protein P.IA;
DE            Short=PIA;
DE            Short=Protein IA;
DE   AltName: Full=Class 1 protein;
DE   Flags: Precursor;
GN   Name=porA; OrderedLocusNames=NMBH4476_0791; ORFNames=NMH_1198;
OS   Neisseria meningitidis serogroup B / serotype 15 (strain H44/76).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=909420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=H44/76;
RX   PubMed=1693651; DOI=10.1084/jem.171.6.1871;
RA   McGuinnes B., Barlow A.K., Clarke I.N., Farley J.E., Anilionis A.,
RA   Poolman J.T., Heckels J.E.;
RT   "Deduced amino acid sequences of class 1 protein (PorA) from three strains
RT   of Neisseria meningitidis. Synthetic peptides define the epitopes
RT   responsible for serosubtype specificity.";
RL   J. Exp. Med. 171:1871-1882(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H44/76;
RX   PubMed=21378179; DOI=10.1128/jb.01331-10;
RA   Piet J.R., Huis In 't Veld R.A., van Schaik B.D., van Kampen A.H., Baas F.,
RA   van de Beek D., Pannekoek Y., van der Ende A.;
RT   "Genome sequence of Neisseria meningitidis serogroup B strain H44/76.";
RL   J. Bacteriol. 193:2371-2372(2011).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H44/76;
RX   PubMed=21368196; DOI=10.1073/pnas.1019751108;
RA   Budroni S., Siena E., Hotopp J.C., Seib K.L., Serruto D., Nofroni C.,
RA   Comanducci M., Riley D.R., Daugherty S.C., Angiuoli S.V., Covacci A.,
RA   Pizza M., Rappuoli R., Moxon E.R., Tettelin H., Medini D.;
RT   "Neisseria meningitidis is structured in clades associated with restriction
RT   modification systems that modulate homologous recombination.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:4494-4499(2011).
CC   -!- FUNCTION: Serves as a slightly cation selective porin. Major antigen on
CC       the gonococcal cell surface and it may have pathogenic properties in
CC       addition to its porin activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR   EMBL; X52995; CAA37184.1; -; Genomic_DNA.
DR   EMBL; AEQZ01000029; EFV63516.1; -; Genomic_DNA.
DR   EMBL; CP002420; ADY95410.1; -; Genomic_DNA.
DR   PIR; T01682; T01682.
DR   RefSeq; WP_002244169.1; NZ_AEQZ01000029.1.
DR   PDB; 2MPA; X-ray; 2.60 A; P=199-206.
DR   PDBsum; 2MPA; -.
DR   AlphaFoldDB; E6MXW0; -.
DR   SMR; E6MXW0; -.
DR   ABCD; E6MXW0; 7 sequenced antibodies.
DR   EnsemblBacteria; EFV63516; EFV63516; NMH_1198.
DR   KEGG; nmh:NMBH4476_0791; -.
DR   PATRIC; fig|909420.3.peg.1096; -.
DR   HOGENOM; CLU_038238_4_0_4; -.
DR   OMA; GDKTKNS; -.
DR   BioCyc; NMEN909420:NMBH4476_RS04440-MON; -.
DR   Proteomes; UP000032707; Unassembled WGS sequence.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   CDD; cd00342; gram_neg_porins; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR033900; Gram_neg_porin_domain.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   InterPro; IPR013793; Porin_Gram-ve_CS.
DR   InterPro; IPR002299; Porin_Neis.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00182; ECOLNEIPORIN.
DR   PRINTS; PR00184; NEISSPPORIN.
DR   PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell outer membrane; Ion transport; Membrane; Porin; Signal;
KW   Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..392
FT                   /note="Major outer membrane protein P.IA"
FT                   /id="PRO_0000411248"
SQ   SEQUENCE   392 AA;  42079 MW;  919EA0F1F396E7A4 CRC64;
     MRKKLTALVL SALPLAAVAD VSLYGEIKAG VEGRNYQLQL TEAQAANGGA SGQVKVTKVT
     KAKSRIRTKI SDFGSFIGFK GSEDLGDGLK AVWQLEQDVS VAGGGATQWG NRESFIGLAG
     EFGTLRAGRV ANQFDDASQA IDPWDSNNDV ASQLGIFKRH DDMPVSVRYD SPEFSGFSGS
     VQFVPIQNSK SAYTPAYYTK DTNNNLTLVP AVVGKPGSDV YYAGLNYKNG GFAGNYAFKY
     ARHANVGRNA FELFLIGSGS DQAKGTDPLK NHQVHRLTGG YEEGGLNLAL AAQLDLSENG
     DKTKNSTTEI AATASYRFGN AVPRISYAHG FDFIERGKKG ENTSYDQIIA GVDYDFSKRT
     SAIVSGAWLK RNTGIGNYTQ INAASVGLRH KF