ID   OMPA_SHIBL              Reviewed;         241 AA.
AC   P0DJO6; Q03617; Q99124;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2012, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Outer membrane protein A {ECO:0000250|UniProtKB:P0A910};
DE   AltName: Full=Outer membrane porin A {ECO:0000250|UniProtKB:P0A910};
DE   AltName: Full=Outer membrane protein 3A {ECO:0000303|PubMed:1955870};
DE   Flags: Fragment;
GN   Name=ompA {ECO:0000250|UniProtKB:P0A910};
OS   Shimwellia blattae (Escherichia blattae).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shimwellia.
OX   NCBI_TaxID=563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 33429 / CDC 1182-73, and ATCC 33430 / CDC 2928-78;
RX   PubMed=1955870; DOI=10.1099/00221287-137-8-1911;
RA   Lawrence J.G., Ochman H., Hartl D.L.;
RT   "Molecular and evolutionary relationships among enteric bacteria.";
RL   J. Gen. Microbiol. 137:1911-1921(1991).
CC   -!- FUNCTION: With TolR probably plays a role in maintaining the position
CC       of the peptidoglycan cell wall in the periplasm. Acts as a porin with
CC       low permeability that allows slow penetration of small solutes; an
CC       internal gate slows down solute passage.
CC       {ECO:0000250|UniProtKB:P0A910}.
CC   -!- SUBUNIT: Monomer and homodimer. {ECO:0000250|UniProtKB:P0A910}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P0A910}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P0A910}.
CC   -!- DOMAIN: The extracellular loops are most variable in sequence, and in
CC       some bacteria confer sensitivity to phage and/or colicins.
CC       {ECO:0000250|UniProtKB:P0A910}.
CC   -!- SIMILARITY: Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
CC       OmpA family. {ECO:0000305}.
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DR   EMBL; M63344; AAA24239.1; -; Genomic_DNA.
DR   EMBL; M63345; AAA24242.1; -; Genomic_DNA.
DR   PIR; I62391; I62391.
DR   PIR; I62394; I62394.
DR   AlphaFoldDB; P0DJO6; -.
DR   SMR; P0DJO6; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   CDD; cd07185; OmpA_C-like; 1.
DR   Gene3D; 3.30.1330.60; -; 1.
DR   InterPro; IPR011250; OMP/PagP_b-brl.
DR   InterPro; IPR006664; OMP_bac.
DR   InterPro; IPR002368; OmpA.
DR   InterPro; IPR006665; OmpA-like.
DR   InterPro; IPR006690; OMPA-like_CS.
DR   InterPro; IPR036737; OmpA-like_sf.
DR   InterPro; IPR000498; OmpA-like_TM_dom.
DR   Pfam; PF00691; OmpA; 1.
DR   Pfam; PF01389; OmpA_membrane; 1.
DR   PRINTS; PR01021; OMPADOMAIN.
DR   PRINTS; PR01022; OUTRMMBRANEA.
DR   SUPFAM; SSF103088; SSF103088; 1.
DR   SUPFAM; SSF56925; SSF56925; 1.
DR   PROSITE; PS01068; OMPA_1; 1.
DR   PROSITE; PS51123; OMPA_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Disulfide bond; Ion transport; Membrane; Porin;
KW   Repeat; Transmembrane; Transmembrane beta strand; Transport.
FT   CHAIN           <1..>241
FT                   /note="Outer membrane protein A"
FT                   /id="PRO_0000196253"
FT   TRANSMEM        <1..8
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250|UniProtKB:P0A910"
FT   TRANSMEM        13..21
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250|UniProtKB:P0A910"
FT   TRANSMEM        46..55
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250|UniProtKB:P0A910"
FT   TRANSMEM        60..67
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250|UniProtKB:P0A910"
FT   TRANSMEM        86..94
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250|UniProtKB:P0A910"
FT   REPEAT          105..106
FT                   /note="1"
FT   REPEAT          107..108
FT                   /note="2"
FT   REPEAT          109..110
FT                   /note="3"
FT   REPEAT          111..112
FT                   /note="4"
FT   DOMAIN          114..>241
FT                   /note="OmpA-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00473"
FT   REGION          105..112
FT                   /note="4 X 2 AA tandem repeats of A-P"
FT   SITE            63
FT                   /note="Part of salt bridge gating mechanism"
FT                   /evidence="ECO:0000250|UniProtKB:P0A910"
FT   DISULFID        215..227
FT                   /evidence="ECO:0000250|UniProtKB:P0A910"
FT   VARIANT         33
FT                   /note="G -> V (in strain: ATCC 33430)"
FT   VARIANT         56
FT                   /note="W -> M (in strain: ATCC 33430)"
FT   VARIANT         100
FT                   /note="Missing (in strain: ATCC 33430)"
FT   NON_TER         1
FT   NON_TER         241
SQ   SEQUENCE   241 AA;  25917 MW;  21E1DD11BDFE164C CRC64;
     LTAKLSYPIY DDLDIYTRLG GMVWRADAKN NVGGGDRSNH DTGVSPVFAG GVEYAWTPSI
     ATRLEYQWIN NIGDAGTVGT RPDNGMLSVG VSYRFGQDEA APVVAPAPAP APQVQTKHFT
     LKSDVLFNFN KSTLKPEGQQ ALDQLYTQLS NLDPKDGAVV VLGYTDRIGS DAYNQRLSQQ
     RAQSVVDYLV SKGIPAGKIT AQGQGESNPV TGSTCDNVKQ RAALIDCLAP DRRVEIEVKG
     V