ID   OMPB1_NEIGO             Reviewed;         348 AA.
AC   P18195; P97161;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Major outer membrane protein P.IB;
DE            Short=PIB;
DE            Short=Protein IB;
DE   AltName: Full=Porin;
DE   Flags: Precursor;
GN   Name=porB;
OS   Neisseria gonorrhoeae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=P9 / Serovar IB-26;
RX   PubMed=1696003; DOI=10.1093/nar/18.14.4258;
RA   Butt N.J., Lambden P.R., Heckels J.E.;
RT   "The nucleotide sequence of the por gene from Neisseria gonorrhoeae strain
RT   P9 encoding outer membrane protein PIB.";
RL   Nucleic Acids Res. 18:4258-4258(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 175-268.
RC   STRAIN=S4 / Serovar IB-4;
RX   PubMed=8232067; DOI=10.1007/bf00190266;
RA   Lau Q., Chow V., Poh C.;
RT   "Polymerase chain reaction and direct sequencing of Neisseria gonorrhoeae
RT   protein IB gene: partial nucleotide and amino acid sequence analysis of
RT   strains S4, S11, S48 (serovar IB4) and S34 (serovar IB5).";
RL   Med. Microbiol. Immunol. 182:137-145(1993).
CC   -!- FUNCTION: Serves as a slightly cation selective porin. Major antigen on
CC       the gonococcal cell surface and it may have pathogenic properties in
CC       addition to its porin activity.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR   EMBL; X52823; CAA37005.1; -; Genomic_DNA.
DR   EMBL; U07827; AAA53549.1; -; Genomic_DNA.
DR   PIR; S10509; MMNHPB.
DR   AlphaFoldDB; P18195; -.
DR   SMR; P18195; -.
DR   Reactome; R-HSA-3000484; Scavenging by Class F Receptors.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071682; C:endocytic vesicle lumen; TAS:Reactome.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   CDD; cd00342; gram_neg_porins; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR033900; Gram_neg_porin_domain.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   InterPro; IPR013793; Porin_Gram-ve_CS.
DR   InterPro; IPR002299; Porin_Neis.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00182; ECOLNEIPORIN.
DR   PRINTS; PR00184; NEISSPPORIN.
DR   PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..19
FT   CHAIN           20..348
FT                   /note="Major outer membrane protein P.IB"
FT                   /id="PRO_0000025277"
SQ   SEQUENCE   348 AA;  37417 MW;  5A2646DCBC11BFEA CRC64;
     MKKSLIALTL AALPVAATAD VTLYGAIKAG VQTYRSVEHT DGKVSKVETG SEIADFGSKI
     GFKGQEDLGN GLKAVWQLEQ GASVAGTNTG WGNKQSFVGL KGGFGTIRAG SLNSPLKNTD
     ANVNAWESGK FTGNVLEISG MAKREHRYLS VRYDSPEFAG FSGSVQYAPK DNSGSNGESY
     HVGLNYQNSG FFAQYAGLFQ RYGEGTKKIE YEHQVYSIPS LFVEKLQVHR LVGGYDNNAL
     YVSVAAQQQD AKLYGARRAN SHNSQTEVAA TAAYRFGNVT PRVSYAHGFK GTVDSADHDN
     TYDQVVVGAE YDFSKRTSAL VSAGWLQEGK GADKIVSTAS AVVLRHKF