ID   OMPB3_NEIMI             Reviewed;         331 AA.
AC   P30688;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Major outer membrane protein P.IB;
DE            Short=PIB;
DE            Short=Protein IB;
DE   AltName: Full=Class 3 protein;
DE   AltName: Full=Porin;
DE   Flags: Precursor;
GN   Name=porB;
OS   Neisseria meningitidis serogroup B.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CCUG 37604 / M981 / Serogroup B / Serotype 4;
RX   PubMed=1330818; DOI=10.1016/0378-1097(92)90644-4;
RA   Ward M.J., Lambden P.R., Heckels J.E.;
RT   "Sequence analysis and relationships between meningococcal class 3 serotype
RT   proteins and other porins from pathogenic and non-pathogenic Neisseria
RT   species.";
RL   FEMS Microbiol. Lett. 73:283-289(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CU385 / Serogroup B / Serotype 4 / Subtype 15;
RX   PubMed=1335540; DOI=10.1111/j.1365-2958.1992.tb01784.x;
RA   Zapata G.A., Vann W.F., Rubinstein Y., Frasch C.E.;
RT   "Identification of variable region differences in Neisseria meningitidis
RT   class 3 protein sequences among five group B serotypes.";
RL   Mol. Microbiol. 6:3493-3499(1992).
CC   -!- FUNCTION: Serves as a slightly cation selective porin.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X65531; CAA46501.1; -; Genomic_DNA.
DR   PIR; S21409; S21409.
DR   PIR; S28441; S28441.
DR   AlphaFoldDB; P30688; -.
DR   SMR; P30688; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   CDD; cd00342; gram_neg_porins; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR033900; Gram_neg_porin_domain.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   InterPro; IPR013793; Porin_Gram-ve_CS.
DR   InterPro; IPR002299; Porin_Neis.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00182; ECOLNEIPORIN.
DR   PRINTS; PR00184; NEISSPPORIN.
DR   PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..19
FT   CHAIN           20..331
FT                   /note="Major outer membrane protein P.IB"
FT                   /id="PRO_0000025283"
FT   VARIANT         70..71
FT                   /note="NG -> KR (in strain: CU385)"
SQ   SEQUENCE   331 AA;  35741 MW;  35EA35B7EBD28301 CRC64;
     MKKSLIALTL AALPVAAMAD VTLYGTIKAG VETSRSVEHN GGQVVSVETG TGIVDLGSKI
     GFKGQEDLGN GLKAIWQVEQ KASIAGTDSG WGNRQSFIGL KGGFGKLRVG RLNSVLKDTG
     DINPWDSKSD YLGVNKIAEP EARLISVRYD SPEFAGLSGS VQYALNDNAG KYNSESYHAG
     FNYKNGGFFV QYGGAYKRHV RVDENVNIEK YQIHRLVSGY DNDALHASVA VQQQDAKLVE
     DNYSHNSQTE VAATLAYRFG NVTPRVSYAH GFKGSFDDAD LSNDYDQVVV GAEYDFSKRT
     SALVSAGWLQ EGKGENKFVS TAGGVGLRHK F