ID   OMPB_NEIMH              Reviewed;         331 AA.
AC   E6MZM0;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Major outer membrane protein P.IB;
DE            Short=PIB;
DE            Short=Protein IB;
DE   AltName: Full=Class 3 protein;
DE   AltName: Full=Porin;
DE   Flags: Precursor;
GN   Name=porB; OrderedLocusNames=NMBH4476_1982; ORFNames=NMH_2035;
OS   Neisseria meningitidis serogroup B / serotype 15 (strain H44/76).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=909420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H44/76;
RA   Piet J.R., Huis in 't Veld R., van Schaik B., van Kampen A., Baas F.,
RA   van de Beek D., Pannekoek Y., van der Ende A.;
RT   "Genome Sequence of Neisseria meningitidis serogroup B strain H44/76.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H44/76;
RX   PubMed=21368196; DOI=10.1073/pnas.1019751108;
RA   Budroni S., Siena E., Hotopp J.C., Seib K.L., Serruto D., Nofroni C.,
RA   Comanducci M., Riley D.R., Daugherty S.C., Angiuoli S.V., Covacci A.,
RA   Pizza M., Rappuoli R., Moxon E.R., Tettelin H., Medini D.;
RT   "Neisseria meningitidis is structured in clades associated with restriction
RT   modification systems that modulate homologous recombination.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:4494-4499(2011).
RN   [3]
RP   PROTEIN SEQUENCE OF 20-38.
RC   STRAIN=H44/76;
RX   PubMed=2492968; DOI=10.1128/iai.57.3.1005-1007.1989;
RA   Poolman J.T., Timmermans H.A., Teerlink T., Seid R.C. Jr.;
RT   "Purification, cyanogen bromide cleavage, and amino terminus sequencing of
RT   class 1 and class 3 outer membrane proteins of meningococci.";
RL   Infect. Immun. 57:1005-1007(1989).
CC   -!- FUNCTION: Serves as a slightly cation selective porin. {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR   EMBL; AEQZ01000043; EFV62899.1; -; Genomic_DNA.
DR   EMBL; CP002420; ADY96541.1; -; Genomic_DNA.
DR   RefSeq; WP_002244345.1; NZ_AEQZ01000043.1.
DR   AlphaFoldDB; E6MZM0; -.
DR   SMR; E6MZM0; -.
DR   PRIDE; E6MZM0; -.
DR   EnsemblBacteria; EFV62899; EFV62899; NMH_2035.
DR   KEGG; nmh:NMBH4476_1982; -.
DR   PATRIC; fig|909420.3.peg.2663; -.
DR   HOGENOM; CLU_038238_4_0_4; -.
DR   OMA; YKADAMS; -.
DR   BioCyc; NMEN909420:NMBH4476_RS10975-MON; -.
DR   Proteomes; UP000032707; Unassembled WGS sequence.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   CDD; cd00342; gram_neg_porins; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR033900; Gram_neg_porin_domain.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   InterPro; IPR013793; Porin_Gram-ve_CS.
DR   InterPro; IPR002299; Porin_Neis.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00182; ECOLNEIPORIN.
DR   PRINTS; PR00184; NEISSPPORIN.
DR   PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Direct protein sequencing; Ion transport; Membrane;
KW   Porin; Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..331
FT                   /note="Major outer membrane protein P.IB"
FT                   /id="PRO_0000411119"
SQ   SEQUENCE   331 AA;  35682 MW;  D6945BC81B04B6AF CRC64;
     MKKSLIALTL AALPVAAMAD VTLYGTIKAG VETSRSVFHQ NGQVTEVTTA TGIVDLGSKI
     GFKGQEDLGN GLKAIWQVEQ KASIAGTDSG WGNRQSFIGL KGGFGKLRVG RLNSVLKDTG
     DINPWDSKSD YLGVNKIAEP EARLISVRYD SPEFAGLSGS VQYALNDNAG RHNSESYHAG
     FNYKNGGFFV QYGGAYKRHH QVQEGLNIEK YQIHRLVSGY DNDALYASVA VQQQDAKLTD
     ASNSHNSQTE VAATLAYRFG NVTPRVSYAH GFKGLVDDAD IGNEYDQVVV GAEYDFSKRT
     SALVSAGWLQ EGKGENKFVA TAGGVGLRHK F