ID   OMPC1_SHIFM             Reviewed;         373 AA.
AC   A0A4P7TKC8;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   31-JUL-2019, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Outer membrane porin C 1 {ECO:0000305};
DE   AltName: Full=Outer membrane protein C 1;
DE   AltName: Full=Porin OmpC1;
DE   Flags: Precursor;
GN   Name=ompC1 {ECO:0000305}; ORFNames=EKN05_004405;
OS   Shigella flexneri serotype 5a (strain M90T).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=1086030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a;
RA   Cervantes-Rivera R., Puhar A.;
RT   "Complete genome sequence and annotation of the laboratory reference strain
RT   Shigella flexneri 5a M90T and genome-wide transcription start site
RT   determination.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION IN VIRULENCE, SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=M90T / Serotype 5a;
RX   PubMed=8359885; DOI=10.1128/iai.61.9.3625-3635.1993;
RA   Bernardini M.L., Sanna M.G., Fontaine A., Sansonetti P.J.;
RT   "OmpC is involved in invasion of epithelial cells by Shigella flexneri.";
RL   Infect. Immun. 61:3625-3635(1993).
CC   -!- FUNCTION: Forms pores that allow passive diffusion of small molecules
CC       across the outer membrane (Probable). Plays a role in virulence
CC       (PubMed:8359885). {ECO:0000269|PubMed:8359885, ECO:0000305}.
CC   -!- SUBUNIT: Homotrimer. Forms mixed heterotrimers with OmpF and with PhoE;
CC       other mixed heterotrimers are also probable.
CC       {ECO:0000250|UniProtKB:P06996}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:8359885};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:P06996}.
CC   -!- INDUCTION: Unlike E.coli, constitutively expressed at low and high
CC       osmolarity (0.3M NaCl) (at protein level). Expression is under the
CC       control of OmpR-EnvZ two-component system; still expressed at very low
CC       levels in high osmolarity in the absence of ompR-envZ (at protein
CC       elevel). {ECO:0000269|PubMed:8359885}.
CC   -!- DISRUPTION PHENOTYPE: Lowered rate of infection of HeLa cells. Bacteria
CC       are seriously impaired in their ability to spread from host cell to
CC       host cell. {ECO:0000269|PubMed:8359885}.
CC   -!- MISCELLANEOUS: This strain has 2 ompC genes; it is not clear which one
CC       has been detected in cell outer membranes nor deleted in
CC       PubMed:8359885. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR   EMBL; CP037923; QCC31083.1; -; Genomic_DNA.
DR   RefSeq; WP_000865562.1; NZ_CM001474.1.
DR   AlphaFoldDB; A0A4P7TKC8; -.
DR   SMR; A0A4P7TKC8; -.
DR   EnsemblBacteria; QCC31083; QCC31083; EKN05_004405.
DR   GeneID; 58388744; -.
DR   Proteomes; UP000296678; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001897; Porin_gammaproteobac.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   InterPro; IPR013793; Porin_Gram-ve_CS.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00183; ECOLIPORIN.
DR   PRINTS; PR00182; ECOLNEIPORIN.
DR   PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..373
FT                   /note="Outer membrane porin C 1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5020643036"
SQ   SEQUENCE   373 AA;  41402 MW;  15711869390ACCB2 CRC64;
     MKVKVLSLLV PALLVAGAAN AAEVYNKDGN KLDLYGKVDG LHYFSDDKSV DGDQTYMRLG
     FKGETQVTDQ LTGYGQWEYQ IQGNSAENEN NSWTRVAFAG LKFQDVGSFD YGRNYGVVYD
     VTSWTDVLPE FGGDTYGSDN FMQQRGNGFA TYRSTDFFGL VDGLNFAVQY QGKNGSPEGE
     GMTNNGREAL RQNGDGVGGS ITYDYEGFGI GAAVSSSKRT DDQNFGLNRY DERYIGNGDR
     AETYTGGLKY DANNIYLAAQ YTQTYNATRV GNLGWANKAQ NFEAVAQYQF DFGLRPSLAY
     LQSKGKNLGV INGRNYDDED ILKYVDVGAT YYFNKNMSTY VDYKINLLDD NQFTRDAGIN
     TDNIVALGLV YQF