A28_YMTV5
ID A28_YMTV5 Reviewed; 141 AA.
AC P60672;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2004, sequence version 1.
DT 25-MAY-2022, entry version 56.
DE RecName: Full=Envelope protein A28 homolog;
DE AltName: Full=Protein 118;
GN OrderedLocusNames=118L;
OS Yaba monkey tumor virus (strain VR587) (YMTV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Yatapoxvirus.
OX NCBI_TaxID=928314;
OH NCBI_TaxID=9538; Erythrocebus patas (Red guenon) (Cercopithecus patas).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9539; Macaca (macaques).
OH NCBI_TaxID=9557; Papio hamadryas (Hamadryas baboon).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14645589; DOI=10.1128/jvi.77.24.13335-13347.2003;
RA Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X.,
RA Barrett J.W., McFadden G.;
RT "Complete genomic sequence and comparative analysis of the tumorigenic
RT poxvirus Yaba monkey tumor virus.";
RL J. Virol. 77:13335-13347(2003).
CC -!- FUNCTION: Envelope protein required for virus entry into host cell and
CC for cell-cell fusion (syncytium formation). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type
CC II membrane protein {ECO:0000305}. Note=Component of the intracellular
CC mature virion (IMV) membrane. {ECO:0000250}.
CC -!- PTM: Contains two intramolecular disulfide bonds. They are created by
CC the viral disulfide bond formation pathway, a poxvirus-specific pathway
CC that operates on the cytoplasmic side of the MV membranes (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the poxviridae A28 protein family.
CC {ECO:0000305}.
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DR EMBL; AY386371; AAR07474.1; -; Genomic_DNA.
DR RefSeq; NP_938373.1; NC_005179.1.
DR GeneID; 2943712; -.
DR KEGG; vg:2943712; -.
DR Proteomes; UP000008596; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR InterPro; IPR007664; Poxvirus_A28.
DR Pfam; PF04584; Pox_A28; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Fusion of virus membrane with host membrane; Late protein;
KW Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix; Viral envelope protein;
KW Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT CHAIN 1..141
FT /note="Envelope protein A28 homolog"
FT /id="PRO_0000099302"
FT TRANSMEM 1..21
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 22..141
FT /note="Virion surface"
FT /evidence="ECO:0000255"
SQ SEQUENCE 141 AA; 16562 MW; E68877848C8DA77F CRC64;
MNPTSIVLIV IATVAVCLII MQIYYIYENY DNIKEFNSTH STLEYSKTIN VFSLDRRIYD
PNDHIYDVKQ KWRCVNYKNN YVSVSVFGFK SNKDKNIKMF TTINDCINYT FSKSTHSDIY
NPCILDDGFQ NQDCIFLKSV I