ID   OMPC_ENTCC              Reviewed;         363 AA.
AC   A0A0H3CMG2;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Outer membrane porin C;
DE   AltName: Full=Outer membrane protein 1B;
DE   AltName: Full=Outer membrane protein C;
DE   AltName: Full=Porin OmpC;
DE   Flags: Precursor;
GN   Name=ompC; OrderedLocusNames=ECL_03519;
OS   Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC
OS   13535 / NCTC 10005 / WDCM 00083 / NCDC 279-56).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX   NCBI_TaxID=716541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13047 / DSM 30054 / NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC
RC   279-56;
RX   PubMed=20207761; DOI=10.1128/jb.00067-10;
RA   Ren Y., Ren Y., Zhou Z., Guo X., Li Y., Feng L., Wang L.;
RT   "Complete genome sequence of Enterobacter cloacae subsp. cloacae type
RT   strain ATCC 13047.";
RL   J. Bacteriol. 192:2463-2464(2010).
RN   [2]
RP   FUNCTION (MICROBIAL INFECTION).
RC   STRAIN=ATCC 13047 / DSM 30054 / NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC
RC   279-56;
RX   PubMed=27723824; DOI=10.1371/journal.ppat.1005925;
RA   Beck C.M., Willett J.L., Cunningham D.A., Kim J.J., Low D.A., Hayes C.S.;
RT   "CdiA effectors from uropathogenic Escherichia coli use heterotrimeric
RT   osmoporins as receptors to recognize target bacteria.";
RL   PLoS Pathog. 12:E1005925-E1005925(2016).
CC   -!- FUNCTION: Forms pores that allow passive diffusion of small molecules
CC       across the outer membrane.
CC   -!- FUNCTION: (Microbial infection) Binds CdiA-EC536, probably acts as the
CC       outer membrane receptor for toxin CdiA-EC536 with OmpF.
CC       {ECO:0000269|PubMed:27723824}.
CC   -!- SUBUNIT: Homotrimer. Probably forms mixed heterotrimers with OmpF;
CC       other mixed heterotrimers are also probable.
CC       {ECO:0000250|UniProtKB:P06996}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000305|PubMed:27723824}; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR   EMBL; CP001918; ADF63053.1; -; Genomic_DNA.
DR   RefSeq; WP_013098006.1; NC_014121.1.
DR   RefSeq; YP_003614002.1; NC_014121.1.
DR   AlphaFoldDB; A0A0H3CMG2; -.
DR   SMR; A0A0H3CMG2; -.
DR   STRING; 716541.ECL_03519; -.
DR   EnsemblBacteria; ADF63053; ADF63053; ECL_03519.
DR   KEGG; enc:ECL_03519; -.
DR   PATRIC; fig|716541.4.peg.3681; -.
DR   eggNOG; COG3203; Bacteria.
DR   HOGENOM; CLU_058202_0_0_6; -.
DR   OMA; DNKENSW; -.
DR   Proteomes; UP000002363; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001897; Porin_gammaproteobac.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   InterPro; IPR013793; Porin_Gram-ve_CS.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00183; ECOLIPORIN.
DR   PRINTS; PR00182; ECOLNEIPORIN.
DR   PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..363
FT                   /note="Outer membrane porin C"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5002606566"
FT   REGION          174..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   363 AA;  39940 MW;  681370F63C3075B6 CRC64;
     MKVKVLSLLV PALLVAGAAN AAEIYNKDGN KLDLYGKVDG LHYFSDDDSQ DGDQTYMRLG
     FKGETQVNDQ LTGYGQWEYQ IQGNSGENEN NSWTRVAFAG LKFGDAGSFD YGRNYGVVYD
     VTSWTDVLPE FGGDTYGSDN FMQQRGNGFA TYRNSDFFGL VDGLNFAVQY QGKNGSASGE
     DQTNNGRTEL RQNGDGVGGS ITYNLGEGFG IGTAVSSSKR TSSQNDLTYG NGDRAETYTG
     GLKYDANNIY LAAQYTQTYN ATRVGNLGWA NKAQNFEVVA QYQFDFGLRP SVAYLQSKGK
     DLENGYGDQD LLKYVDVGAT YYFNKNMSTY VDYKINLLDD KEFTRNAGIS TDDIVALGLV
     YQF