ID   OMPC_NEIGO              Reviewed;         270 AA.
AC   P09888;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Outer membrane protein P.IIC;
DE            Short=Protein IIC;
DE   Flags: Precursor;
GN   Name=piiC;
OS   Neisseria gonorrhoeae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=JS3;
RX   PubMed=3145386; DOI=10.1111/j.1365-2958.1988.tb00091.x;
RA   van der Ley P.;
RT   "Three copies of a single protein II-encoding sequence in the genome of
RT   Neisseria gonorrhoeae JS3: evidence for gene conversion and gene
RT   duplication.";
RL   Mol. Microbiol. 2:797-806(1988).
RN   [2]
RP   PROTEIN SEQUENCE OF 26-45.
RX   PubMed=3114142; DOI=10.1128/iai.55.9.2026-2031.1987;
RA   Barritt D.S., Schwalbe R.S., Klapper D.G., Cannon J.G.;
RT   "Antigenic and structural differences among six proteins II expressed by a
RT   single strain of Neisseria gonorrhoeae.";
RL   Infect. Immun. 55:2026-2031(1987).
CC   -!- FUNCTION: This protein serves as a porin.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the opacity porin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X12625; CAA31144.1; -; Genomic_DNA.
DR   PIR; S03095; KONH2C.
DR   AlphaFoldDB; P09888; -.
DR   SMR; P09888; -.
DR   PRIDE; P09888; -.
DR   Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR   GO; GO:0009279; C:cell outer membrane; TAS:Reactome.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR011250; OMP/PagP_b-brl.
DR   InterPro; IPR016373; Opacity.
DR   InterPro; IPR003394; Porin_opacity.
DR   Pfam; PF02462; Opacity; 1.
DR   PIRSF; PIRSF002984; Opacity; 1.
DR   SUPFAM; SSF56925; SSF56925; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Direct protein sequencing; Ion transport; Membrane;
KW   Porin; Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000269|PubMed:3114142"
FT   CHAIN           26..270
FT                   /note="Outer membrane protein P.IIC"
FT                   /id="PRO_0000025197"
FT   TOPO_DOM        26..35
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..44
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..76
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..85
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..89
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..96
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        97..142
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..157
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..162
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..173
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..221
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..234
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..237
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..246
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        247..261
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..270
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   REGION          194..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        30
FT                   /note="G -> N (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        40
FT                   /note="L -> K (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        44
FT                   /note="A -> Y (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   270 AA;  30269 MW;  F6B448373830A50D CRC64;
     MQPAKNLLFS SLLFSSLLFS SAARAASEDG GRGPYVQADL AYAAERITHD YPKPTGTGKN
     KISTVSDYFR NIRTHSVHPR VSVGYDFGSW RIAADYARYR KWNNNKYSVS IKELLRNDNS
     ASGVRGHLNI QTQKTEHQEN GTFHAVSSLG LSTIYDFDTG SRFKPYIGMR VAYGHVRHQV
     RSVEQETEII TTYPSNGGGK VSLSSKMPPK SAHHQSNSIR RVGLGVIAGV GFDITPNLTL
     DTGYRYHNWG RLENTRFKTH EASLGMRYRF