ID   OMPC_SALTS              Reviewed;         378 AA.
AC   A0A0H3NJI9;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2020, sequence version 2.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Outer membrane porin C {ECO:0000305|PubMed:22538806};
DE   AltName: Full=Outer membrane protein C;
DE   AltName: Full=Porin OmpC;
DE   Flags: Precursor;
GN   Name=ompC {ECO:0000303|PubMed:22538806}; OrderedLocusNames=SL1344_2237;
OS   Salmonella typhimurium (strain SL1344).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=216597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL1344;
RX   PubMed=22538806; DOI=10.1073/pnas.1201061109;
RA   Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K.,
RA   Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A.,
RA   Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S.,
RA   Ussery D.W., Dorman C.J., Thomson N.R., Vogel J., Hinton J.C.;
RT   "The transcriptional landscape and small RNAs of Salmonella enterica
RT   serovar Typhimurium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012).
RN   [2]
RP   SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=SL1344;
RX   PubMed=2543631; DOI=10.1128/iai.57.7.2136-2140.1989;
RA   Dorman C.J., Chatfield S., Higgins C.F., Hayward C., Dougan G.;
RT   "Characterization of porin and ompR mutants of a virulent strain of
RT   Salmonella typhimurium: ompR mutants are attenuated in vivo.";
RL   Infect. Immun. 57:2136-2140(1989).
CC   -!- FUNCTION: Forms pores that allow passive diffusion of small molecules
CC       across the outer membrane. {ECO:0000305}.
CC   -!- SUBUNIT: Homotrimer. Forms mixed heterotrimers with OmpF and with PhoE;
CC       other mixed heterotrimers with other porins are also probable.
CC       {ECO:0000250|UniProtKB:P06996}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:2543631};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:P06996}.
CC   -!- INDUCTION: By growth in high osmolarity conditions under control of
CC       OmpR (at protein level). {ECO:0000269|PubMed:2543631}.
CC   -!- DISRUPTION PHENOTYPE: No effect on virulence in male BALB/c mice.
CC       {ECO:0000269|PubMed:2543631}.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CBW18339.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; FQ312003; CBW18339.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000865526.1; NZ_QASL01000010.1.
DR   AlphaFoldDB; A0A0H3NJI9; -.
DR   SMR; A0A0H3NJI9; -.
DR   EnsemblBacteria; CBW18339; CBW18339; SL1344_2237.
DR   KEGG; sey:SL1344_2237; -.
DR   PATRIC; fig|216597.6.peg.2492; -.
DR   HOGENOM; CLU_058202_0_0_6; -.
DR   Proteomes; UP000008962; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001897; Porin_gammaproteobac.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   InterPro; IPR013793; Porin_Gram-ve_CS.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00183; ECOLIPORIN.
DR   PRINTS; PR00182; ECOLNEIPORIN.
DR   PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal;
KW   Stress response; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..378
FT                   /note="Outer membrane porin C"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000448910"
SQ   SEQUENCE   378 AA;  41239 MW;  58479E8685B43ED1 CRC64;
     MKVKVLSLLV PALLVAGAAN AAEIYNKDGN KLDLFGKVDG LHYFSDDKGS DGDQTYMRIG
     FKGETQVNDQ LTGYGQWEYQ IQGNQTEGSN DSWTRVAFAG LKFADAGSFD YGRNYGVTYD
     VTSWTDVLPE FGGDTYGADN FMQQRGNGYA TYRNTDFFGL VDGLDFALQY QGKNGSVSGE
     NTNGRSLLNQ NGDGYGGSLT YAIGEGFSVG GAITTSKRTA DQNNTANARL YGNGDRATVY
     TGGLKYDANN IYLAAQYSQT YNATRFGTSN GSNPSTSYGF ANKAQNFEVV AQYQFDFGLR
     PSVAYLQSKG KDISNGYGAS YGDQDIVKYV DVGATYYFNK NMSTYVDYKI NLLDKNDFTR
     DAGINTDDIV ALGLVYQF