ID   OMPC_SALTY              Reviewed;         378 AA.
AC   P0A263; O52503; P09878;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Outer membrane porin C;
DE   AltName: Full=Outer membrane protein C;
DE   AltName: Full=Porin OmpC;
DE   Flags: Precursor;
GN   Name=ompC; OrderedLocusNames=STM2267;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX   PubMed=10528398; DOI=10.1139/w99-053;
RA   Negm R.S., Pistole T.G.;
RT   "The porin OmpC of Salmonella typhimurium mediates adherence to
RT   macrophages.";
RL   Can. J. Microbiol. 45:658-669(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Forms pores that allow passive diffusion of small molecules
CC       across the outer membrane.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR   EMBL; AF039309; AAB96675.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL21169.1; -; Genomic_DNA.
DR   EMBL; M31424; AAA27169.1; -; Genomic_DNA.
DR   PIR; A59139; A59139.
DR   RefSeq; NP_461210.1; NC_003197.2.
DR   RefSeq; WP_000865526.1; NC_003197.2.
DR   AlphaFoldDB; P0A263; -.
DR   SMR; P0A263; -.
DR   STRING; 99287.STM2267; -.
DR   PaxDb; P0A263; -.
DR   PRIDE; P0A263; -.
DR   EnsemblBacteria; AAL21169; AAL21169; STM2267.
DR   GeneID; 1253789; -.
DR   KEGG; stm:STM2267; -.
DR   PATRIC; fig|99287.12.peg.2401; -.
DR   HOGENOM; CLU_058202_0_0_6; -.
DR   OMA; DNKENSW; -.
DR   PhylomeDB; P0A263; -.
DR   BioCyc; SENT99287:STM2267-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001897; Porin_gammaproteobac.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   InterPro; IPR013793; Porin_Gram-ve_CS.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00183; ECOLIPORIN.
DR   PRINTS; PR00182; ECOLNEIPORIN.
DR   PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Reference proteome;
KW   Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..378
FT                   /note="Outer membrane porin C"
FT                   /id="PRO_0000025235"
FT   CONFLICT        42
FT                   /note="H -> N (in Ref. 1; AAB96675)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        223
FT                   /note="N -> D (in Ref. 1; AAB96675)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        253
FT                   /note="L -> V (in Ref. 1; AAB96675)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        258
FT                   /note="S -> F (in Ref. 1; AAB96675)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        340
FT                   /note="K -> T (in Ref. 1; AAB96675)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        356..357
FT                   /note="ND -> YE (in Ref. 1; AAB96675)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   378 AA;  41239 MW;  58479E8685B43ED1 CRC64;
     MKVKVLSLLV PALLVAGAAN AAEIYNKDGN KLDLFGKVDG LHYFSDDKGS DGDQTYMRIG
     FKGETQVNDQ LTGYGQWEYQ IQGNQTEGSN DSWTRVAFAG LKFADAGSFD YGRNYGVTYD
     VTSWTDVLPE FGGDTYGADN FMQQRGNGYA TYRNTDFFGL VDGLDFALQY QGKNGSVSGE
     NTNGRSLLNQ NGDGYGGSLT YAIGEGFSVG GAITTSKRTA DQNNTANARL YGNGDRATVY
     TGGLKYDANN IYLAAQYSQT YNATRFGTSN GSNPSTSYGF ANKAQNFEVV AQYQFDFGLR
     PSVAYLQSKG KDISNGYGAS YGDQDIVKYV DVGATYYFNK NMSTYVDYKI NLLDKNDFTR
     DAGINTDDIV ALGLVYQF