ID   OMPF_ECOL5              Reviewed;         362 AA.
AC   P0DSD9; A0A454A2T9;
DT   05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT   05-JUN-2019, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Outer membrane porin F;
DE   AltName: Full=Outer membrane protein F;
DE   AltName: Full=Porin OmpF;
DE   Flags: Precursor;
GN   Name=ompF; OrderedLocusNames=ECP_0940;
OS   Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=362663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=536 / UPEC;
RX   PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA   Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA   Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT   "Role of pathogenicity island-associated integrases in the genome
RT   plasticity of uropathogenic Escherichia coli strain 536.";
RL   Mol. Microbiol. 61:584-595(2006).
RN   [2]
RP   FUNCTION (MICROBIAL INFECTION), AND SUBUNIT.
RC   STRAIN=K12;
RX   PubMed=27723824; DOI=10.1371/journal.ppat.1005925;
RA   Beck C.M., Willett J.L., Cunningham D.A., Kim J.J., Low D.A., Hayes C.S.;
RT   "CdiA effectors from uropathogenic Escherichia coli use heterotrimeric
RT   osmoporins as receptors to recognize target bacteria.";
RL   PLoS Pathog. 12:E1005925-E1005925(2016).
CC   -!- FUNCTION: Forms pores that allow passive diffusion of small molecules
CC       across the outer membrane. {ECO:0000305}.
CC   -!- FUNCTION: (Microbial infection) Is the major receptor for colicin E5.
CC       {ECO:0000269|PubMed:27723824}.
CC   -!- FUNCTION: (Microbial infection) A mixed OmpC-OmpF heterotrimer is the
CC       outer membrane receptor for toxin CdiA-EC536.
CC       {ECO:0000269|PubMed:27723824}.
CC   -!- SUBUNIT: Homotrimer (Probable). Forms mixed heterotrimers with OmpC;
CC       other mixed heterotrimers are also probable (PubMed:27723824).
CC       {ECO:0000269|PubMed:27723824, ECO:0000305|PubMed:27723824}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000305|PubMed:27723824}; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR   EMBL; CP000247; ABG68955.1; -; Genomic_DNA.
DR   RefSeq; WP_000977927.1; NC_008253.1.
DR   AlphaFoldDB; P0DSD9; -.
DR   SMR; P0DSD9; -.
DR   STRING; 362663.ECP_0940; -.
DR   EnsemblBacteria; ABG68955; ABG68955; ECP_0940.
DR   KEGG; ecp:ECP_0940; -.
DR   OMA; DAIGWTD; -.
DR   Proteomes; UP000009182; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015288; F:porin activity; IEA:InterPro.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   CDD; cd00342; gram_neg_porins; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR033900; Gram_neg_porin_domain.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001897; Porin_gammaproteobac.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   InterPro; IPR013793; Porin_Gram-ve_CS.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00183; ECOLIPORIN.
DR   PRINTS; PR00182; ECOLNEIPORIN.
DR   PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Membrane; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..362
FT                   /note="Outer membrane porin F"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000446879"
SQ   SEQUENCE   362 AA;  39354 MW;  AE27198973A176AE CRC64;
     MMKRNILAVI VPALLVAGTA NAAEIYNKDG NKVDLYGKAV GLHYFSKGNG ENSYGGNGDM
     TYARLGFKGE TQINSDLTGY GQWEYNFQGN NSEGADAQTG NKTRLAFAGL KYADVGSFDY
     GRNYGVVYDA LGYTDMLPEF GGDTAYSDDF FVGRVGGVAT YRNSNFFGLV DGLNFAVQYL
     GKNERDTARR SNGDGVGGSI SYEYEGFGIV GAYGAADRTN LQEESSLGKG KKAEQWATGL
     KYDANNIYLA ANYGETRNAT PITNKFTNTS GFANKTQDVL LVAQYQFDFG LRPSIAYTKS
     KAKDVEGIGD VDLVNYFEVG ATYYFNKNMS TYVDYIINQI DSDNKLGVGS DDTVAVGIVY
     QF