OMPF_SALTI
ID OMPF_SALTI Reviewed; 363 AA.
AC Q56113;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 05-DEC-2001, sequence version 2.
DT 25-MAY-2022, entry version 143.
DE RecName: Full=Outer membrane porin F;
DE AltName: Full=Outer membrane protein F;
DE AltName: Full=Outer membrane protein S3;
DE AltName: Full=Porin OmpF;
DE Flags: Precursor;
GN Name=ompF; Synonyms=ompS3; OrderedLocusNames=STY1002, t1935;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=IMSS-1;
RA Fernandez-Mora M., Calva E.;
RL Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
RN [4]
RP SUBCELLULAR LOCATION, AND INDUCTION.
RC STRAIN=ATCC 700931 / Ty2 / CVD908;
RX PubMed=8063417; DOI=10.1128/iai.62.9.3984-3993.1994;
RA Pickard D.J., Li J., Roberts M.R., Maskell D., Hone D., Levine M.,
RA Dougan G., Chatfield S.;
RT "Characterization of defined ompR mutants of Salmonella typhi: ompR is
RT involved in the regulation of Vi polysaccharide expression.";
RL Infect. Immun. 62:3984-3993(1994).
CC -!- FUNCTION: Forms pores that allow passive diffusion of small molecules
CC across the outer membrane. {ECO:0000305}.
CC -!- SUBUNIT: Homotrimer. Forms mixed heterotrimers with OmpC and with PhoE;
CC other mixed heterotrimers with other porins are also probable.
CC {ECO:0000250|UniProtKB:P02931}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:8063417};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:P02931}.
CC -!- INDUCTION: Unlike E.coli or S.typhimurium both OmpC and OmpF porins are
CC expressed constitutively, i.e. at both high and low osmolarity, under
CC control of OmpR (at protein level). {ECO:0000269|PubMed:8063417}.
CC -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR EMBL; X89757; CAA61905.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD05399.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO69550.1; -; Genomic_DNA.
DR RefSeq; NP_455485.1; NC_003198.1.
DR RefSeq; WP_000977709.1; NZ_WSUR01000013.1.
DR AlphaFoldDB; Q56113; -.
DR SMR; Q56113; -.
DR STRING; 220341.16502161; -.
DR EnsemblBacteria; AAO69550; AAO69550; t1935.
DR KEGG; stt:t1935; -.
DR KEGG; sty:STY1002; -.
DR PATRIC; fig|220341.7.peg.1009; -.
DR eggNOG; COG3203; Bacteria.
DR HOGENOM; CLU_058202_0_0_6; -.
DR OMA; NMTREAD; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR CDD; cd00342; gram_neg_porins; 1.
DR Gene3D; 2.40.160.10; -; 1.
DR InterPro; IPR033900; Gram_neg_porin_domain.
DR InterPro; IPR023614; Porin_dom_sf.
DR InterPro; IPR001897; Porin_gammaproteobac.
DR InterPro; IPR001702; Porin_Gram-ve.
DR InterPro; IPR013793; Porin_Gram-ve_CS.
DR Pfam; PF00267; Porin_1; 1.
DR PRINTS; PR00183; ECOLIPORIN.
DR PRINTS; PR00182; ECOLNEIPORIN.
DR PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW Transmembrane beta strand; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000250"
FT CHAIN 23..363
FT /note="Outer membrane porin F"
FT /id="PRO_0000025238"
FT TRANSMEM 23..28
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 29
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 30..45
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 46..56
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 57..69
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 70..71
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 72..84
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 85..99
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 100..108
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 109
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 110..117
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 118..154
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 155..161
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 162..169
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 170..181
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 182..192
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 193..203
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 204
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 205..217
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 218..230
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 231..242
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 243
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 244..256
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 257..272
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 273..285
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 286..287
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 288..301
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 302..312
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 313..324
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 325..326
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 327..336
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 337..353
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 354..363
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT CONFLICT 307
FT /note="D -> G (in Ref. 1; CAA61905)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 363 AA; 40106 MW; F5059B37EA516859 CRC64;
MMKRKILAAV IPALLAAATA NAAEIYNKDG NKLDLYGKAV GRHVWTTTGD SKNADQTYAQ
IGFKGETQIN TDLTGFGQWE YRTKADRAEG EQQNSNLVRL AFAGLKYAEV GSIDYGRNYG
IVYDVESYTD MAPYFSGETW GGAYTDNYMT SRAGGLLTYR NSDFFGLVDG LSFGIQYQGK
NQDNHSINSQ NGDGVGYTMA YEFDGFGVTA AYSNSKRTND QQDRDGNGDR AESWAVGAKY
DANNVYLAAV YAETRNMSIV ENTVTDTVEM ANKTQNLEVV AQYQFDFGLR PAISYVQSKG
KQLNGADGSA DLAKYIQAGA TYYFNKNMNV WVDYRFNLLD ENDYSSSYVG TDDQAAVGIT
YQF
