OMPF_SALTY
ID OMPF_SALTY Reviewed; 363 AA.
AC P37432;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Outer membrane porin F;
DE AltName: Full=Outer membrane protein 1A;
DE AltName: Full=Outer membrane protein B;
DE AltName: Full=Outer membrane protein F;
DE AltName: Full=Outer membrane protein IA;
DE AltName: Full=Porin OmpF;
DE Flags: Precursor;
GN Name=ompF; OrderedLocusNames=STM0999;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RA Venegas A., Gomez I., Bruce E., Martinez M.;
RL Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Forms pores that allow passive diffusion of small molecules
CC across the outer membrane. It is also a receptor for the bacteriophage
CC T2 (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z31594; CAA83471.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL19933.1; -; Genomic_DNA.
DR PIR; S43159; S43159.
DR RefSeq; NP_459974.1; NC_003197.2.
DR RefSeq; WP_000977713.1; NC_003197.2.
DR PDB; 3NSG; X-ray; 2.79 A; A/B/C=24-363.
DR PDB; 4KR4; X-ray; 3.80 A; A/B/C=24-363.
DR PDB; 4KR8; X-ray; 3.10 A; A/B/C=24-363.
DR PDB; 4KRA; X-ray; 3.32 A; A/B/C=24-363.
DR PDBsum; 3NSG; -.
DR PDBsum; 4KR4; -.
DR PDBsum; 4KR8; -.
DR PDBsum; 4KRA; -.
DR AlphaFoldDB; P37432; -.
DR SMR; P37432; -.
DR STRING; 99287.STM0999; -.
DR PaxDb; P37432; -.
DR EnsemblBacteria; AAL19933; AAL19933; STM0999.
DR GeneID; 1252517; -.
DR KEGG; stm:STM0999; -.
DR PATRIC; fig|99287.12.peg.1052; -.
DR HOGENOM; CLU_058202_0_0_6; -.
DR OMA; NMTREAD; -.
DR PhylomeDB; P37432; -.
DR BioCyc; SENT99287:STM0999-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR CDD; cd00342; gram_neg_porins; 1.
DR Gene3D; 2.40.160.10; -; 1.
DR InterPro; IPR033900; Gram_neg_porin_domain.
DR InterPro; IPR023614; Porin_dom_sf.
DR InterPro; IPR001897; Porin_gammaproteobac.
DR InterPro; IPR001702; Porin_Gram-ve.
DR InterPro; IPR013793; Porin_Gram-ve_CS.
DR Pfam; PF00267; Porin_1; 1.
DR PRINTS; PR00183; ECOLIPORIN.
DR PRINTS; PR00182; ECOLNEIPORIN.
DR PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Ion transport; Membrane; Porin;
KW Reference proteome; Signal; Transmembrane; Transmembrane beta strand;
KW Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000250"
FT CHAIN 23..363
FT /note="Outer membrane porin F"
FT /id="PRO_0000025239"
FT TRANSMEM 23..28
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 29
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 30..45
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 46..56
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 57..69
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 70..71
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 72..84
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 85..99
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 100..108
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 109
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 110..117
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 118..154
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 155..161
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 162..169
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 170..181
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 182..192
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 193..203
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 204
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 205..217
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 218..230
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 231..242
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 243
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 244..256
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 257..272
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 273..285
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 286..287
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 288..301
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 302..312
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 313..324
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 325..326
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 327..336
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 337..353
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 354..363
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT CONFLICT 232
FT /note="E -> A (in Ref. 1; CAA83471)"
FT /evidence="ECO:0000305"
FT CONFLICT 360
FT /note="T -> V (in Ref. 1; CAA83471)"
FT /evidence="ECO:0000305"
FT STRAND 35..46
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 48..50
FT /evidence="ECO:0007829|PDB:4KR8"
FT STRAND 58..67
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 69..72
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 74..84
FT /evidence="ECO:0007829|PDB:3NSG"
FT HELIX 92..94
FT /evidence="ECO:0007829|PDB:4KR8"
FT STRAND 96..107
FT /evidence="ECO:0007829|PDB:3NSG"
FT TURN 108..110
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 111..119
FT /evidence="ECO:0007829|PDB:3NSG"
FT HELIX 123..127
FT /evidence="ECO:0007829|PDB:3NSG"
FT TURN 128..131
FT /evidence="ECO:0007829|PDB:4KRA"
FT STRAND 132..137
FT /evidence="ECO:0007829|PDB:3NSG"
FT TURN 140..142
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 143..147
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 150..167
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 169..178
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 183..185
FT /evidence="ECO:0007829|PDB:3NSG"
FT HELIX 187..189
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 193..203
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 206..215
FT /evidence="ECO:0007829|PDB:3NSG"
FT HELIX 219..221
FT /evidence="ECO:0007829|PDB:4KR8"
FT STRAND 222..226
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 231..242
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 245..256
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 259..262
FT /evidence="ECO:0007829|PDB:4KR8"
FT TURN 263..265
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 267..270
FT /evidence="ECO:0007829|PDB:4KR8"
FT STRAND 272..283
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 286..288
FT /evidence="ECO:0007829|PDB:4KRA"
FT STRAND 291..302
FT /evidence="ECO:0007829|PDB:3NSG"
FT TURN 304..307
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 310..322
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 326..337
FT /evidence="ECO:0007829|PDB:3NSG"
FT TURN 346..349
FT /evidence="ECO:0007829|PDB:3NSG"
FT STRAND 354..363
FT /evidence="ECO:0007829|PDB:3NSG"
SQ SEQUENCE 363 AA; 40048 MW; F6069B34E9516859 CRC64;
MMKRKILAAV IPALLAAATA NAAEIYNKDG NKLDLYGKAV GRHVWTTTGD SKNADQTYAQ
IGFKGETQIN TDLTGFGQWE YRTKADRAEG EQQNSNLVRL AFAGLKYAEV GSIDYGRNYG
IVYDVESYTD MAPYFSGETW GGAYTDNYMT SRAGGLLTYR NSDFFGLVDG LSFGIQYQGK
NQDNHSINSQ NGDGVGYTMA YEFDGFGVTA AYSNSKRTND QQDRDGNGDR AESWAVGAKY
DANNVYLAAV YAETRNMSIV ENTVTDTVEM ANKTQNLEVV AQYQFDFGLR PAISYVQSKG
KQLNGAGGSA DLAKYIQAGA TYYFNKNMNV WVDYRFNLLD ENDYSSSYVG TDDQAAVGIT
YQF
