OMPL_ECOLI
ID OMPL_ECOLI Reviewed; 230 AA.
AC P76773; Q2M8H2;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Porin OmpL;
DE Flags: Precursor;
GN Name=ompL; Synonyms=yshA; OrderedLocusNames=b3875, JW3846;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8346018; DOI=10.1093/nar/21.15.3391;
RA Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome. III. DNA sequence of the region
RT from 87.2 to 89.2 minutes.";
RL Nucleic Acids Res. 21:3391-3398(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP PROTEIN SEQUENCE OF 21-25, CHANNEL FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11080145; DOI=10.1093/emboj/19.22.5980;
RA Dartigalongue C., Nikaido H., Raina S.;
RT "Protein folding in the periplasm in the absence of primary oxidant DsbA:
RT modulation of redox potential in periplasmic space via OmpL porin.";
RL EMBO J. 19:5980-5988(2000).
RN [5]
RP ERRATUM OF PUBMED:11080145.
RX DOI=10.1038/sj.emboj.7600439;
RA Dartigalongue C., Nikaido H., Raina S.;
RL EMBO J. 23:3907-3907(2004).
RN [6]
RP FUNCTION.
RC STRAIN=K12;
RX PubMed=12660153; DOI=10.1093/emboj/cdg152;
RA Sardesai A.A., Genevaux P., Schwager F., Ang D., Georgopoulos C.;
RT "The OmpL porin does not modulate redox potential in the periplasmic space
RT of Escherichia coli.";
RL EMBO J. 22:1461-1466(2003).
CC -!- FUNCTION: Outer membrane channel protein that allows an efficient
CC diffusion of low-molecular-weight solutes such as small sugars and
CC tetraglycine. However, the specific substrate recognized by the OmpL
CC channel is unknown. {ECO:0000269|PubMed:12660153}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000269|PubMed:11080145}.
CC -!- SIMILARITY: Belongs to the oligogalacturonate-specific porin KdgM (TC
CC 1.B.35) family. OmpL subfamily. {ECO:0000305}.
CC -!- CAUTION: In contrast to PubMed:11080145, PubMed:12660153 demonstrates
CC that OmpL actually plays no perceptible role in modulating redox
CC potential in the periplasm of E.coli. {ECO:0000305}.
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DR EMBL; L19201; AAB03009.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U00096; AAC76872.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77434.1; -; Genomic_DNA.
DR PIR; F65192; F65192.
DR RefSeq; NP_418311.1; NC_000913.3.
DR RefSeq; WP_000723465.1; NZ_LN832404.1.
DR AlphaFoldDB; P76773; -.
DR SMR; P76773; -.
DR BioGRID; 4262635; 212.
DR IntAct; P76773; 21.
DR STRING; 511145.b3875; -.
DR TCDB; 1.B.35.2.2; the oligogalacturonate-specific porin (kdgm) family.
DR PaxDb; P76773; -.
DR PRIDE; P76773; -.
DR EnsemblBacteria; AAC76872; AAC76872; b3875.
DR EnsemblBacteria; BAE77434; BAE77434; BAE77434.
DR GeneID; 948366; -.
DR KEGG; ecj:JW3846; -.
DR KEGG; eco:b3875; -.
DR PATRIC; fig|1411691.4.peg.2836; -.
DR EchoBASE; EB3156; -.
DR eggNOG; COG1452; Bacteria.
DR HOGENOM; CLU_103714_0_0_6; -.
DR OMA; ETREAYN; -.
DR PhylomeDB; P76773; -.
DR BioCyc; EcoCyc:G7814-MON; -.
DR PRO; PR:P76773; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IDA:EcoliWiki.
DR GO; GO:0045203; C:integral component of cell outer membrane; IBA:GO_Central.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IDA:EcoCyc.
DR GO; GO:0015751; P:arabinose transmembrane transport; IDA:EcoliWiki.
DR GO; GO:0015757; P:galactose transmembrane transport; IDA:EcoliWiki.
DR GO; GO:0046323; P:glucose import; IDA:EcoliWiki.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0015772; P:oligosaccharide transport; IBA:GO_Central.
DR InterPro; IPR009331; Oligogalacturonate-sp_porin.
DR PANTHER; PTHR38105; PTHR38105; 1.
DR Pfam; PF06178; KdgM; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Direct protein sequencing; Ion transport; Membrane;
KW Porin; Reference proteome; Signal; Sugar transport; Transmembrane;
KW Transmembrane beta strand; Transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000269|PubMed:11080145"
FT CHAIN 21..230
FT /note="Porin OmpL"
FT /id="PRO_0000016605"
SQ SEQUENCE 230 AA; 27200 MW; 94743DA530F276CB CRC64;
MKKINAIILL SSLTSASVFA GAYVENREAY NLASDQGEVM LRVGYNFDMG AGIMLTNTYN
FQREDELKHG YNEIEGWYPL FKPTDKLTIQ PGGLINDKSI GSGGAVYLDV NYKFVPWFNL
TVRNRYNHNN YSSTDLSGEL DNNDTYEIGT YWNFKITDKF SYTFEPHYFM RVNDFNSSNG
KDHHWEITNT FRYRINEHWL PYFELRWLDR NVEPYHREQN QIRIGTKYFF
