ID   OMPR_ECO57              Reviewed;         239 AA.
AC   P0AA18; O31133; P03025; P08981; P41405;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=DNA-binding dual transcriptional regulator OmpR {ECO:0000305};
DE   AltName: Full=Transcriptional regulatory protein OmpR;
GN   Name=ompR; OrderedLocusNames=Z4760, ECs4247;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Member of the two-component regulatory system EnvZ/OmpR
CC       involved in osmoregulation (particularly of genes ompF and ompC) as
CC       well as other genes. Plays a central role in both acid and osmotic
CC       stress responses. Binds to the promoter of both ompC and ompF; at low
CC       osmolarity it activates ompF transcription, while at high osmolarity it
CC       represses ompF and activates ompC transcription.
CC       {ECO:0000250|UniProtKB:P0AA16}.
CC   -!- SUBUNIT: Monomer and multimer. {ECO:0000250|UniProtKB:P0AA16}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P0AA16}.
CC   -!- PTM: Phosphorylated by EnvZ; this stimulates its DNA-binding ability.
CC       Asp-55 is the primary phosphate acceptor site.
CC       {ECO:0000250|UniProtKB:P0AA16}.
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DR   EMBL; AE005174; AAG58506.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37670.1; -; Genomic_DNA.
DR   PIR; F86005; F86005.
DR   PIR; G91159; G91159.
DR   RefSeq; NP_312274.1; NC_002695.1.
DR   RefSeq; WP_001157751.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AA18; -.
DR   SMR; P0AA18; -.
DR   STRING; 155864.EDL933_4605; -.
DR   EnsemblBacteria; AAG58506; AAG58506; Z4760.
DR   EnsemblBacteria; BAB37670; BAB37670; ECs_4247.
DR   GeneID; 8912757; -.
DR   GeneID; 915896; -.
DR   KEGG; ece:Z4760; -.
DR   KEGG; ecs:ECs_4247; -.
DR   PATRIC; fig|386585.9.peg.4435; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_4_6; -.
DR   OMA; NIHGEGF; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW   Repressor; Stress response; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..239
FT                   /note="DNA-binding dual transcriptional regulator OmpR"
FT                   /id="PRO_0000081178"
FT   DOMAIN          6..120
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        135..234
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         55
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000250|UniProtKB:P0AA16,
FT                   ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   239 AA;  27354 MW;  823CA7720E9A1D2A CRC64;
     MQENYKILVV DDDMRLRALL ERYLTEQGFQ VRSVANAEQM DRLLTRESFH LMVLDLMLPG
     EDGLSICRRL RSQSNPMPII MVTAKGEEVD RIVGLEIGAD DYIPKPFNPR ELLARIRAVL
     RRQANELPGA PSQEEAVIAF GKFKLNLGTR EMFREDEPMP LTSGEFAVLK ALVSHPREPL
     SRDKLMNLAR GREYSAMERS IDVQISRLRR MVEEDPAHPR YIQTVWGLGY VFVPDGSKA