ID   OMPR_SALTS              Reviewed;         239 AA.
AC   A0A0H3NGY1;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=DNA-binding dual transcriptional regulator OmpR {ECO:0000305};
DE   AltName: Full=Transcriptional regulatory protein OmpR {ECO:0000305};
GN   Name=ompR {ECO:0000303|PubMed:22538806}; OrderedLocusNames=SL1344_3469;
OS   Salmonella typhimurium (strain SL1344).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=216597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL1344;
RX   PubMed=22538806; DOI=10.1073/pnas.1201061109;
RA   Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K.,
RA   Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A.,
RA   Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S.,
RA   Ussery D.W., Dorman C.J., Thomson N.R., Vogel J., Hinton J.C.;
RT   "The transcriptional landscape and small RNAs of Salmonella enterica
RT   serovar Typhimurium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=SL1344;
RX   PubMed=2543631; DOI=10.1128/iai.57.7.2136-2140.1989;
RA   Dorman C.J., Chatfield S., Higgins C.F., Hayward C., Dougan G.;
RT   "Characterization of porin and ompR mutants of a virulent strain of
RT   Salmonella typhimurium: ompR mutants are attenuated in vivo.";
RL   Infect. Immun. 57:2136-2140(1989).
CC   -!- FUNCTION: Member of the two-component regulatory system EnvZ/OmpR
CC       involved in osmoregulation (particularly of genes ompF and ompC) as
CC       well as other genes (PubMed:2543631). Plays a central role in both acid
CC       and osmotic stress responses. Binds to the promoter of both ompC and
CC       ompF; at low osmolarity it activates ompF transcription, while at high
CC       osmolarity it represses ompF and activates ompC transcription
CC       (Probable). {ECO:0000269|PubMed:2543631, ECO:0000305|PubMed:2543631}.
CC   -!- SUBUNIT: Monomer and multimer. {ECO:0000250|UniProtKB:P0AA16}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P0AA16}.
CC   -!- PTM: Phosphorylated by EnvZ; this stimulates its DNA-binding ability.
CC       Asp-55 is the primary phosphate acceptor site.
CC       {ECO:0000250|UniProtKB:P0AA16}.
CC   -!- DISRUPTION PHENOTYPE: Decreased virulence in male BALB/c mice; mutant
CC       cells are able to colonize mouse tissues and persist for several weeks,
CC       but are about 10(5)-fold less lethal. The deletion is probably polar on
CC       downstream envZ. {ECO:0000269|PubMed:2543631}.
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DR   EMBL; FQ312003; CBW19564.1; -; Genomic_DNA.
DR   RefSeq; WP_001157751.1; NZ_QASL01000006.1.
DR   AlphaFoldDB; A0A0H3NGY1; -.
DR   SMR; A0A0H3NGY1; -.
DR   EnsemblBacteria; CBW19564; CBW19564; SL1344_3469.
DR   GeneID; 8912757; -.
DR   KEGG; sey:SL1344_3469; -.
DR   PATRIC; fig|216597.6.peg.3863; -.
DR   HOGENOM; CLU_000445_30_4_6; -.
DR   OMA; NIHGEGF; -.
DR   BioCyc; SENT216597:SL1344_RS18070-MON; -.
DR   Proteomes; UP000008962; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Repressor;
KW   Stress response; Transcription; Transcription regulation;
KW   Two-component regulatory system; Virulence.
FT   CHAIN           1..239
FT                   /note="DNA-binding dual transcriptional regulator OmpR"
FT                   /id="PRO_0000448906"
FT   DOMAIN          6..120
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        135..234
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         55
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000250|UniProtKB:P0AA16,
FT                   ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   239 AA;  27354 MW;  823CA7720E9A1D2A CRC64;
     MQENYKILVV DDDMRLRALL ERYLTEQGFQ VRSVANAEQM DRLLTRESFH LMVLDLMLPG
     EDGLSICRRL RSQSNPMPII MVTAKGEEVD RIVGLEIGAD DYIPKPFNPR ELLARIRAVL
     RRQANELPGA PSQEEAVIAF GKFKLNLGTR EMFREDEPMP LTSGEFAVLK ALVSHPREPL
     SRDKLMNLAR GREYSAMERS IDVQISRLRR MVEEDPAHPR YIQTVWGLGY VFVPDGSKA