OMPU_VIBC3
ID OMPU_VIBC3 Reviewed; 341 AA.
AC A5F934; C3LXU4; P97085; Q9KU90; Q9L5A3;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Outer membrane protein U;
DE AltName: Full=Porin OmpU;
DE Flags: Precursor;
GN Name=ompU; OrderedLocusNames=VC0395_A0162, VC395_0650;
OS Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS O395).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=345073;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8945596; DOI=10.1128/iai.64.12.5406-5409.1996;
RA Sperandio V., Bailey C.C., Giron J.A., DiRita V.J., Silveira W.D.,
RA Vettore A.L., Kaper J.B.;
RT "Cloning and characterization of the gene encoding the OmpU outer membrane
RT protein of Vibrio cholerae.";
RL Infect. Immun. 64:5406-5409(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA Heidelberg J.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA Wang W., Wang J., Qian W., Li D., Wang L.;
RT "A recalibrated molecular clock and independent origins for the cholera
RT pandemic clones.";
RL PLoS ONE 3:E4053-E4053(2008).
CC -!- FUNCTION: Forms pores that allow passive diffusion of small molecules
CC across the outer membrane. {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABQ21305.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=ACP08668.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U73751; AAB48973.1; -; Genomic_DNA.
DR EMBL; CP000627; ABQ21305.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP001235; ACP08668.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_001044324.1; NZ_JAACZH010000006.1.
DR PDB; 6EHB; X-ray; 1.55 A; A/B/C=22-341.
DR PDB; 6EHC; X-ray; 2.02 A; A/B=33-341.
DR PDBsum; 6EHB; -.
DR PDBsum; 6EHC; -.
DR AlphaFoldDB; A5F934; -.
DR SMR; A5F934; -.
DR STRING; 345073.VC395_0650; -.
DR EnsemblBacteria; ABQ21305; ABQ21305; VC0395_A0162.
DR KEGG; vco:VC0395_A0162; -.
DR KEGG; vcr:VC395_0650; -.
DR PATRIC; fig|345073.21.peg.631; -.
DR eggNOG; COG3203; Bacteria.
DR HOGENOM; CLU_058202_1_2_6; -.
DR Proteomes; UP000000249; Chromosome 2.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR CDD; cd00342; gram_neg_porins; 1.
DR Gene3D; 2.40.160.10; -; 1.
DR InterPro; IPR033900; Gram_neg_porin_domain.
DR InterPro; IPR023614; Porin_dom_sf.
DR Pfam; PF13609; Porin_4; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Ion transport; Membrane; Porin; Signal;
KW Transmembrane; Transmembrane beta strand; Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..341
FT /note="Outer membrane protein U"
FT /id="PRO_0000324808"
FT STRAND 33..37
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 39..56
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 59..62
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 65..77
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 80..90
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 104..115
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 118..126
FT /evidence="ECO:0007829|PDB:6EHB"
FT HELIX 130..133
FT /evidence="ECO:0007829|PDB:6EHB"
FT TURN 134..136
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 139..142
FT /evidence="ECO:0007829|PDB:6EHB"
FT HELIX 151..153
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 154..166
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 169..176
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 179..183
FT /evidence="ECO:0007829|PDB:6EHB"
FT HELIX 192..194
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 196..200
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 205..213
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 217..228
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 231..241
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 243..257
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 260..273
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 276..287
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 290..305
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 308..317
FT /evidence="ECO:0007829|PDB:6EHB"
FT HELIX 327..329
FT /evidence="ECO:0007829|PDB:6EHB"
FT STRAND 332..340
FT /evidence="ECO:0007829|PDB:6EHB"
SQ SEQUENCE 341 AA; 36646 MW; D4094E5DAE441D92 CRC64;
MNKTLIALAV SAAAVATGAY ADGINQSGDK AGSTVYSAKG TSLEVGGRAE ARLSLKDGKA
QDNSRVRLNF LGKAEINDSL YGVGFYEGEF TTNDQGKNAS NNSLDNRYTY AGIGGTYGEV
TYGKNDGALG VITDFTDIMS YHGNTAAEKI AVADRVDNML AYKGQFGDLG VKASYRFADR
NAVDAMGNVV TETNAAKYSD NGEDGYSLSA IYTFGDTGFN VGAGYADQDD QNEYMLAASY
RMENLYFAGL FTDGELAKDV DYTGYELAAG YKLGQAAFTA TYNNAETAKK TSADNFAIDA
TYYFKPNFRS YISYQFNLLD SDKASKVASE DELAIGLRYD F
