OMPU_VIBCH
ID OMPU_VIBCH Reviewed; 341 AA.
AC P0C6Q6; P97085; Q9KU90; Q9L5A3;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Outer membrane protein U;
DE AltName: Full=Porin OmpU;
DE Flags: Precursor;
GN Name=ompU; OrderedLocusNames=VC_0633;
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=El Tor;
RA Yin Y., Zhang J.Z.;
RT "Cloning and expression of ompU of Vibrio cholerae and its antigenicity
RT analysis.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- FUNCTION: Forms pores that allow passive diffusion of small molecules
CC across the outer membrane. {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF93799.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF253529; AAF64526.1; -; Genomic_DNA.
DR EMBL; AE003852; AAF93799.1; ALT_INIT; Genomic_DNA.
DR PIR; A82299; A82299.
DR RefSeq; NP_230282.1; NC_002505.1.
DR RefSeq; WP_001044323.1; NZ_LT906614.1.
DR PDB; 5ONU; X-ray; 2.22 A; A/B/C=1-341.
DR PDBsum; 5ONU; -.
DR AlphaFoldDB; P0C6Q6; -.
DR SMR; P0C6Q6; -.
DR STRING; 243277.VC_0633; -.
DR TCDB; 1.B.1.1.15; the general bacterial porin (gbp) family.
DR DNASU; 2615421; -.
DR EnsemblBacteria; AAF93799; AAF93799; VC_0633.
DR GeneID; 57739348; -.
DR KEGG; vch:VC_0633; -.
DR PATRIC; fig|243277.26.peg.603; -.
DR eggNOG; COG3203; Bacteria.
DR HOGENOM; CLU_058202_1_2_6; -.
DR OMA; TIANKTQ; -.
DR PHI-base; PHI:707; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR CDD; cd00342; gram_neg_porins; 1.
DR Gene3D; 2.40.160.10; -; 1.
DR InterPro; IPR033900; Gram_neg_porin_domain.
DR InterPro; IPR023614; Porin_dom_sf.
DR Pfam; PF13609; Porin_4; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Ion transport; Membrane; Porin;
KW Reference proteome; Signal; Transmembrane; Transmembrane beta strand;
KW Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..341
FT /note="Outer membrane protein U"
FT /id="PRO_0000025288"
FT CONFLICT 278
FT /note="F -> I (in Ref. 1; AAF64526)"
FT /evidence="ECO:0000305"
FT STRAND 33..56
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 59..62
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 65..77
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 80..91
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 103..115
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 118..126
FT /evidence="ECO:0007829|PDB:5ONU"
FT HELIX 130..133
FT /evidence="ECO:0007829|PDB:5ONU"
FT TURN 134..136
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 140..142
FT /evidence="ECO:0007829|PDB:5ONU"
FT HELIX 151..153
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 154..166
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 169..176
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 179..183
FT /evidence="ECO:0007829|PDB:5ONU"
FT HELIX 192..194
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 196..200
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 205..213
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 217..228
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 231..242
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 245..257
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 260..272
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 277..287
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 290..305
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 308..317
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 321..324
FT /evidence="ECO:0007829|PDB:5ONU"
FT HELIX 327..329
FT /evidence="ECO:0007829|PDB:5ONU"
FT STRAND 332..340
FT /evidence="ECO:0007829|PDB:5ONU"
SQ SEQUENCE 341 AA; 36645 MW; CECB39070E441732 CRC64;
MNKTLIALAV SAAAVATGAY ADGINQSGDK AGSTVYSAKG TSLEVGGRAE ARLSLKDGKA
QDNSRVRLNF LGKAEINDSL YGVGFYEGEF TTNDQGKNAS NNSLDNRYTY AGIGGTYGEV
TYGKNDGALG VITDFTDIMS YHGNTAAEKI AVADRVDNML AYKGQFGDLG VKASYRFADR
NAVDAMGNVV TETNAAKYSD NGEDGYSLSA IYTFGDTGFN VGAGYADQDD QNEYMLAASY
RMENLYFAGL FTDGELAKDV DYTGYELAAG YKLGQAAFTA TYNNAETAKE TSADNFAIDA
TYYFKPNFRS YISYQFNLLD SDKVGKVASE DELAIGLRYD F
