ID   OMPU_VIBPA              Reviewed;         337 AA.
AC   Q87LZ1;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Outer membrane protein U;
DE   AltName: Full=Porin OmpU;
DE   Flags: Precursor;
GN   Name=ompU; OrderedLocusNames=VP2467;
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
CC   -!- FUNCTION: Forms pores that allow passive diffusion of small molecules
CC       across the outer membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR   EMBL; BA000031; BAC60730.1; -; Genomic_DNA.
DR   RefSeq; NP_798846.1; NC_004603.1.
DR   RefSeq; WP_005490380.1; NC_004603.1.
DR   AlphaFoldDB; Q87LZ1; -.
DR   SMR; Q87LZ1; -.
DR   STRING; 223926.28807465; -.
DR   TCDB; 1.B.1.1.30; the general bacterial porin (gbp) family.
DR   EnsemblBacteria; BAC60730; BAC60730; BAC60730.
DR   GeneID; 1189982; -.
DR   KEGG; vpa:VP2467; -.
DR   PATRIC; fig|223926.6.peg.2367; -.
DR   eggNOG; COG3203; Bacteria.
DR   HOGENOM; CLU_058202_1_2_6; -.
DR   OMA; TIANKTQ; -.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   CDD; cd00342; gram_neg_porins; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR033900; Gram_neg_porin_domain.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   Pfam; PF13609; Porin_4; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Reference proteome;
KW   Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..337
FT                   /note="Outer membrane protein U"
FT                   /id="PRO_0000025289"
SQ   SEQUENCE   337 AA;  36285 MW;  B4DC997166573B50 CRC64;
     MKKTLIALSV SAAAMATGVN AAELYNQDGT SLEMGGRAEA RLSMKDGDAQ DNSRIRLNFL
     GTQAINDNLY GVGFWEGEFT TNEQGGVDGD VNKDSSNLDT RYAYAGLGGA WGEFTYGKNE
     GALGVITDFT DIMAYHGNSA ADKLAVADRS DNMMSYKGQF ENLSVKASYR FADRKLNDAG
     TEYTDNGQDG YSLSAIYAVA DTGLELGAGY ADQDEANEYM LAASYTMGDL YFAGIFTDGE
     KAKTEGDYTG YELAGAYTLG QTVFTTTYNN AETNNETSAN NFAVDASYYF KPNFRGYVSY
     NFNLIDSGDK LGKVGGNTTA SKADAEDELA LGLRYDF