OMPW_ECOLI
ID OMPW_ECOLI Reviewed; 212 AA.
AC P0A915; P21364; P97217; P97220;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Outer membrane protein W;
DE Flags: Precursor;
GN Name=ompW; Synonyms=yciD; OrderedLocusNames=b1256, JW1248;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=3058546; DOI=10.1093/genetics/120.2.345;
RA Stoltzfus A., Leslie J.F., Milkman R.;
RT "Molecular evolution of the Escherichia coli chromosome. I. Analysis of
RT structure and natural variation in a previously uncharacterized region
RT between trp and tonB.";
RL Genetics 120:345-358(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-173.
RC STRAIN=K12, and Various ECOR strains;
RA Milkman R.;
RL Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP PROTEIN SEQUENCE OF 22-26.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9629924; DOI=10.1002/elps.1150190539;
RA Molloy M.P., Herbert B.R., Walsh B.J., Tyler M.I., Traini M.,
RA Sanchez J.-C., Hochstrasser D.F., Williams K.L., Gooley A.A.;
RT "Extraction of membrane proteins by differential solubilization for
RT separation using two-dimensional gel electrophoresis.";
RL Electrophoresis 19:837-844(1998).
RN [7]
RP FUNCTION AS A COLICIN RECEPTOR.
RX PubMed=10348872; DOI=10.1128/jb.181.11.3578-3581.1999;
RA Pilsl H., Smajs D., Braun V.;
RT "Characterization of colicin S4 and its receptor, OmpW, a minor protein of
RT the Escherichia coli outer membrane.";
RL J. Bacteriol. 181:3578-3581(1999).
CC -!- FUNCTION: Acts as a receptor for colicin S4.
CC {ECO:0000269|PubMed:10348872}.
CC -!- INTERACTION:
CC P0A915; P0AC47: frdB; NbExp=2; IntAct=EBI-1132929, EBI-906724;
CC -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC -!- SIMILARITY: Belongs to the OmpW/AlkL family. {ECO:0000305}.
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DR EMBL; X13583; CAA31922.1; -; Genomic_DNA.
DR EMBL; U00096; AAC74338.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA14788.1; -; Genomic_DNA.
DR EMBL; U24195; AAB60065.1; -; Genomic_DNA.
DR EMBL; U24196; AAB60073.1; -; Genomic_DNA.
DR EMBL; U24197; AAB60081.1; -; Genomic_DNA.
DR EMBL; U24198; AAB60089.1; -; Genomic_DNA.
DR EMBL; U24199; AAB60097.1; -; Genomic_DNA.
DR EMBL; U24200; AAB60105.1; -; Genomic_DNA.
DR EMBL; U24201; AAB60113.1; -; Genomic_DNA.
DR EMBL; U24202; AAB60121.1; -; Genomic_DNA.
DR EMBL; U24203; AAB60129.1; -; Genomic_DNA.
DR EMBL; U24204; AAB60137.1; -; Genomic_DNA.
DR EMBL; U24205; AAB60145.1; -; Genomic_DNA.
DR EMBL; U24206; AAB60153.1; -; Genomic_DNA.
DR PIR; S07797; S07797.
DR PIR; T45501; T45501.
DR RefSeq; NP_415772.1; NC_000913.3.
DR RefSeq; WP_000737226.1; NZ_STEB01000005.1.
DR PDB; 2F1T; X-ray; 3.00 A; A/B/C=22-212.
DR PDB; 2F1V; X-ray; 2.70 A; A/B/C/D/E/F=22-212.
DR PDBsum; 2F1T; -.
DR PDBsum; 2F1V; -.
DR AlphaFoldDB; P0A915; -.
DR BMRB; P0A915; -.
DR SMR; P0A915; -.
DR BioGRID; 4263000; 230.
DR IntAct; P0A915; 5.
DR MINT; P0A915; -.
DR STRING; 511145.b1256; -.
DR DrugBank; DB04233; (Hydroxyethyloxy)Tri(Ethyloxy)Octane.
DR DrugBank; DB04147; Dodecyldimethylamine N-oxide.
DR TCDB; 1.B.39.1.6; the bacterial porin, ompw (ompw) family.
DR jPOST; P0A915; -.
DR PaxDb; P0A915; -.
DR PRIDE; P0A915; -.
DR EnsemblBacteria; AAC74338; AAC74338; b1256.
DR EnsemblBacteria; BAA14788; BAA14788; BAA14788.
DR GeneID; 66674921; -.
DR GeneID; 945128; -.
DR KEGG; ecj:JW1248; -.
DR KEGG; eco:b1256; -.
DR PATRIC; fig|1411691.4.peg.1027; -.
DR EchoBASE; EB1114; -.
DR eggNOG; COG3047; Bacteria.
DR HOGENOM; CLU_042505_1_1_6; -.
DR InParanoid; P0A915; -.
DR OMA; DYMLTDN; -.
DR PhylomeDB; P0A915; -.
DR BioCyc; EcoCyc:EG11124-MON; -.
DR EvolutionaryTrace; P0A915; -.
DR PRO; PR:P0A915; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IDA:EcoCyc.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR011250; OMP/PagP_b-brl.
DR InterPro; IPR005618; OMPW.
DR PANTHER; PTHR36920; PTHR36920; 1.
DR Pfam; PF03922; OmpW; 1.
DR SUPFAM; SSF56925; SSF56925; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Direct protein sequencing; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane beta strand.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:9629924"
FT CHAIN 22..212
FT /note="Outer membrane protein W"
FT /id="PRO_0000020190"
FT VARIANT 12
FT /note="T -> A (in strain: ECOR 52 and ECOR 60)"
FT VARIANT 20
FT /note="F -> Y (in strain: ECOR 46 and ECOR 50)"
FT STRAND 27..37
FT /evidence="ECO:0007829|PDB:2F1V"
FT STRAND 57..80
FT /evidence="ECO:0007829|PDB:2F1V"
FT STRAND 82..88
FT /evidence="ECO:0007829|PDB:2F1V"
FT TURN 89..91
FT /evidence="ECO:0007829|PDB:2F1V"
FT STRAND 92..100
FT /evidence="ECO:0007829|PDB:2F1V"
FT STRAND 103..109
FT /evidence="ECO:0007829|PDB:2F1V"
FT STRAND 116..135
FT /evidence="ECO:0007829|PDB:2F1V"
FT HELIX 137..141
FT /evidence="ECO:0007829|PDB:2F1V"
FT STRAND 144..149
FT /evidence="ECO:0007829|PDB:2F1V"
FT STRAND 152..164
FT /evidence="ECO:0007829|PDB:2F1V"
FT STRAND 166..178
FT /evidence="ECO:0007829|PDB:2F1V"
FT STRAND 181..190
FT /evidence="ECO:0007829|PDB:2F1V"
FT STRAND 195..198
FT /evidence="ECO:0007829|PDB:2F1V"
FT STRAND 202..212
FT /evidence="ECO:0007829|PDB:2F1V"
SQ SEQUENCE 212 AA; 22928 MW; FE6C1208CCF11224 CRC64;
MKKLTVAALA VTTLLSGSAF AHEAGEFFMR AGSATVRPTE GAGGTLGSLG GFSVTNNTQL
GLTFTYMATD NIGVELLAAT PFRHKIGTRA TGDIATVHHL PPTLMAQWYF GDASSKFRPY
VGAGINYTTF FDNGFNDHGK EAGLSDLSLK DSWGAAGQVG VDYLINRDWL VNMSVWYMDI
DTTANYKLGG AQQHDSVRLD PWVFMFSAGY RF
