ARUR_PSEAE
ID ARUR_PSEAE Reviewed; 244 AA.
AC Q9HUI2;
DT 05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Transcriptional regulatory protein AruR;
GN Name=aruR; OrderedLocusNames=PA4983;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [2]
RP FUNCTION, PATHWAY, DISRUPTION PHENOTYPE, AND GENE NAME.
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=17416670; DOI=10.1128/jb.00261-07;
RA Yang Z., Lu C.D.;
RT "Functional genomics enables identification of genes of the arginine
RT transaminase pathway in Pseudomonas aeruginosa.";
RL J. Bacteriol. 189:3945-3953(2007).
CC -!- FUNCTION: Member of the two-component regulatory system AruS/AruR,
CC which is involved in the regulation of the arginine transaminase (ATA)
CC pathway in response to exogeneous L-arginine. Regulates transcription
CC of aruH and aruI. {ECO:0000269|PubMed:17416670}.
CC -!- PATHWAY: Amino-acid degradation; L-arginine degradation [regulation].
CC {ECO:0000269|PubMed:17416670}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- PTM: Phosphorylated by AruS. {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Disruption in the aruF mutant prevents growth on
CC L-arginine. {ECO:0000269|PubMed:17416670}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE004091; AAG08368.1; -; Genomic_DNA.
DR PIR; H83022; H83022.
DR RefSeq; NP_253670.1; NC_002516.2.
DR RefSeq; WP_003095718.1; NZ_QZGE01000002.1.
DR AlphaFoldDB; Q9HUI2; -.
DR SMR; Q9HUI2; -.
DR STRING; 287.DR97_2337; -.
DR PaxDb; Q9HUI2; -.
DR EnsemblBacteria; AAG08368; AAG08368; PA4983.
DR GeneID; 880341; -.
DR KEGG; pae:PA4983; -.
DR PATRIC; fig|208964.12.peg.5221; -.
DR PseudoCAP; PA4983; -.
DR HOGENOM; CLU_000445_30_4_6; -.
DR InParanoid; Q9HUI2; -.
DR OMA; PNDRSID; -.
DR PhylomeDB; Q9HUI2; -.
DR BioCyc; PAER208964:G1FZ6-5099-MON; -.
DR UniPathway; UPA00073; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006527; P:arginine catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..244
FT /note="Transcriptional regulatory protein AruR"
FT /id="PRO_0000418390"
FT DOMAIN 6..124
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 139..239
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 60
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 244 AA; 27177 MW; 85ADDB5F867C427A CRC64;
MAMVPRVLVV DDDPVIRELL QAYLGEEGYD VLCAGNAEQA EACLAECAHL GQPVELVLLD
IRLPGKDGLT LTRELRVRSE VGIILITGRN DEIDRIVGLE CGADDYVIKP LNPRELVSRA
KNLIRRVRHA QASAGPARQA LRQFGDWLLD ADRRRLIDHA GNETLLTHGE FQLLGAFLRN
SGHTLSRDQL MDQIRNREWL PSDRSIDVLV GRLRRKLRDD PAEPQLIITI HGAGYLFTAA
ASDA
