OMP_MOUSE
ID OMP_MOUSE Reviewed; 163 AA.
AC Q64288;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory marker protein;
GN Name=Omp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8111122; DOI=10.1007/bf00360561;
RA Brown K.A., Sutcliffe M.J., Steele K., Brown S.D.;
RT "Sequencing of the olfactory marker protein gene in normal and shaker-1
RT mutant mice.";
RL Mamm. Genome 5:11-14(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129;
RX PubMed=8034318; DOI=10.1006/geno.1994.1200;
RA Buiakova O.I., Rama Krishna N.S., Getchell T.V., Margolis F.L.;
RT "Human and rodent OMP genes: conservation of structural and regulatory
RT motifs and cellular localization.";
RL Genomics 20:452-462(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH BEX1 AND BEX2.
RX PubMed=12911636; DOI=10.1046/j.1471-4159.2003.01940.x;
RA Behrens M., Margolis J.W., Margolis F.L.;
RT "Identification of members of the Bex gene family as olfactory marker
RT protein (OMP) binding partners.";
RL J. Neurochem. 86:1289-1296(2003).
RN [5]
RP INTERACTION WITH BEX1 AND BEX2.
RX PubMed=15198671; DOI=10.1111/j.1471-4159.2004.02463.x;
RA Koo J.H., Gill S., Pannell L.K., Menco B.P.M., Margolis J.W.,
RA Margolis F.L.;
RT "The interaction of Bex and OMP reveals a dimer of OMP with a short half-
RT life.";
RL J. Neurochem. 90:102-116(2004).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
RX PubMed=12054872; DOI=10.1016/s0022-2836(02)00242-5;
RA Smith P.C., Firestein S., Hunt J.F.;
RT "The crystal structure of the olfactory marker protein at 2.3 A
RT resolution.";
RL J. Mol. Biol. 319:807-821(2002).
CC -!- FUNCTION: May act as a modulator of the olfactory signal-transduction
CC cascade.
CC -!- SUBUNIT: Interacts with BEX1 and BEX2. {ECO:0000269|PubMed:12911636,
CC ECO:0000269|PubMed:15198671}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Uniquely associated with mature olfactory receptor
CC neurons.
CC -!- SIMILARITY: Belongs to the olfactory marker protein family.
CC {ECO:0000305}.
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DR EMBL; U02557; AAA18415.1; -; Unassigned_DNA.
DR EMBL; U01213; AAA20486.1; -; Genomic_DNA.
DR EMBL; BC046600; AAH46600.1; -; mRNA.
DR CCDS; CCDS21466.1; -.
DR PIR; B54261; B54261.
DR RefSeq; NP_035140.1; NM_011010.2.
DR PDB; 1F35; X-ray; 2.30 A; A/B=2-163.
DR PDB; 1JOB; X-ray; 2.40 A; A=2-163.
DR PDB; 1JOD; X-ray; 3.20 A; A/B=2-163.
DR PDBsum; 1F35; -.
DR PDBsum; 1JOB; -.
DR PDBsum; 1JOD; -.
DR AlphaFoldDB; Q64288; -.
DR BMRB; Q64288; -.
DR SMR; Q64288; -.
DR MINT; Q64288; -.
DR STRING; 10090.ENSMUSP00000095882; -.
DR iPTMnet; Q64288; -.
DR PhosphoSitePlus; Q64288; -.
DR MaxQB; Q64288; -.
DR PaxDb; Q64288; -.
DR PRIDE; Q64288; -.
DR ProteomicsDB; 289989; -.
DR Antibodypedia; 52917; 175 antibodies from 27 providers.
DR Ensembl; ENSMUST00000098281; ENSMUSP00000095882; ENSMUSG00000074006.
DR GeneID; 18378; -.
DR KEGG; mmu:18378; -.
DR UCSC; uc009ike.1; mouse.
DR CTD; 4975; -.
DR MGI; MGI:97436; Omp.
DR VEuPathDB; HostDB:ENSMUSG00000074006; -.
DR eggNOG; ENOG502S0KQ; Eukaryota.
DR GeneTree; ENSGT00390000009497; -.
DR HOGENOM; CLU_1834469_0_0_1; -.
DR InParanoid; Q64288; -.
DR OMA; LRFSHWT; -.
DR OrthoDB; 1264425at2759; -.
DR PhylomeDB; Q64288; -.
DR TreeFam; TF330820; -.
DR BioGRID-ORCS; 18378; 1 hit in 70 CRISPR screens.
DR EvolutionaryTrace; Q64288; -.
DR PRO; PR:Q64288; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q64288; protein.
DR Bgee; ENSMUSG00000074006; Expressed in olfactory bulb and 48 other tissues.
DR ExpressionAtlas; Q64288; baseline and differential.
DR Genevisible; Q64288; MM.
DR GO; GO:0030424; C:axon; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005829; C:cytosol; IDA:MGI.
DR GO; GO:0043025; C:neuronal cell body; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0042277; F:peptide binding; ISO:MGI.
DR GO; GO:0022008; P:neurogenesis; IDA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; IMP:MGI.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.120.390; -; 1.
DR InterPro; IPR009103; Olfactory_marker.
DR InterPro; IPR036727; Olfactory_marker_sf.
DR PANTHER; PTHR15357; PTHR15357; 1.
DR Pfam; PF06554; Olfactory_mark; 1.
DR SUPFAM; SSF63697; SSF63697; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Olfaction; Reference proteome;
KW Sensory transduction.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P08523"
FT CHAIN 2..163
FT /note="Olfactory marker protein"
FT /id="PRO_0000058045"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P08523"
FT STRAND 10..14
FT /evidence="ECO:0007829|PDB:1F35"
FT HELIX 19..34
FT /evidence="ECO:0007829|PDB:1F35"
FT STRAND 50..56
FT /evidence="ECO:0007829|PDB:1F35"
FT STRAND 61..83
FT /evidence="ECO:0007829|PDB:1F35"
FT TURN 89..91
FT /evidence="ECO:0007829|PDB:1F35"
FT HELIX 96..98
FT /evidence="ECO:0007829|PDB:1F35"
FT STRAND 104..108
FT /evidence="ECO:0007829|PDB:1F35"
FT STRAND 110..112
FT /evidence="ECO:0007829|PDB:1JOD"
FT STRAND 115..117
FT /evidence="ECO:0007829|PDB:1F35"
FT HELIX 119..135
FT /evidence="ECO:0007829|PDB:1F35"
FT STRAND 137..145
FT /evidence="ECO:0007829|PDB:1F35"
FT HELIX 151..153
FT /evidence="ECO:0007829|PDB:1F35"
FT STRAND 154..162
FT /evidence="ECO:0007829|PDB:1F35"
SQ SEQUENCE 163 AA; 18867 MW; D50EA5937D7EAE16 CRC64;
MAEDGPQKQQ LEMPLVLDQD LTQQMRLRVE SLKQRGEKKQ DGEKLIRPAE SVYRLDFIQQ
QKLQFDHWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL DPAAIFWRKE DSDAMDWNEA
DALEFGERLS DLAKIRKVMY FLITFGEGVE PANLKASVVF NQL
