OMP_RAT
ID OMP_RAT Reviewed; 163 AA.
AC P08523;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Olfactory marker protein;
DE AltName: Full=Olfactory neuronal-specific protein;
GN Name=Omp;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3470751; DOI=10.1073/pnas.84.6.1704;
RA Rogers K.E., Dasgupta P., Gubler U., Grillo M., Khew-Goodall Y.S.,
RA Margolis F.L.;
RT "Molecular cloning and sequencing of a cDNA for olfactory marker protein.";
RL Proc. Natl. Acad. Sci. U.S.A. 84:1704-1708(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=2701951; DOI=10.1073/pnas.86.21.8565;
RA Danciger E., Mettling C., Vidal M., Morris R., Margolis F.L.;
RT "Olfactory marker protein gene: its structure and olfactory neuron-specific
RT expression in transgenic mice.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:8565-8569(1989).
RN [3]
RP PROTEIN SEQUENCE OF 2-163, CLEAVAGE OF INITIATOR METHIONINE, AND
RP ACETYLATION AT ALA-2.
RX PubMed=3753006; DOI=10.1016/0003-9861(86)90011-1;
RA Sydor W., Teitelbaum Z., Blacher R., Sun S., Benz W., Margolis F.L.;
RT "Amino acid sequence of a unique neuronal protein: rat olfactory marker
RT protein.";
RL Arch. Biochem. Biophys. 249:351-362(1986).
RN [4]
RP STRUCTURE BY NMR.
RX PubMed=12054873; DOI=10.1016/s0022-2836(02)00282-6;
RA Baldisseri D.M., Margolis J.W., Weber D.J., Koo J.H., Margolis F.L.;
RT "Olfactory marker protein (OMP) exhibits a beta-clam fold in solution:
RT implications for target peptide interaction and olfactory signal
RT transduction.";
RL J. Mol. Biol. 319:823-837(2002).
CC -!- FUNCTION: May act as a modulator of the olfactory signal-transduction
CC cascade.
CC -!- SUBUNIT: Interacts with BEX1 and BEX2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Uniquely associated with mature olfactory receptor
CC neurons.
CC -!- SIMILARITY: Belongs to the olfactory marker protein family.
CC {ECO:0000305}.
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DR EMBL; M15644; AAA41757.1; -; mRNA.
DR EMBL; M26926; AAA03054.1; -; Unassigned_DNA.
DR PIR; A27450; A27450.
DR RefSeq; NP_036748.1; NM_012616.1.
DR PDB; 1JYT; NMR; -; A=1-163.
DR PDB; 1ZRI; NMR; -; A=1-163.
DR PDBsum; 1JYT; -.
DR PDBsum; 1ZRI; -.
DR AlphaFoldDB; P08523; -.
DR BMRB; P08523; -.
DR SMR; P08523; -.
DR BioGRID; 246751; 1.
DR iPTMnet; P08523; -.
DR World-2DPAGE; 0004:P08523; -.
DR PRIDE; P08523; -.
DR Ensembl; ENSRNOT00000118298; ENSRNOP00000078319; ENSRNOG00000068492.
DR GeneID; 24612; -.
DR KEGG; rno:24612; -.
DR UCSC; RGD:3231; rat.
DR CTD; 4975; -.
DR RGD; 3231; Omp.
DR GeneTree; ENSGT00390000009497; -.
DR InParanoid; P08523; -.
DR OrthoDB; 1264425at2759; -.
DR PhylomeDB; P08523; -.
DR EvolutionaryTrace; P08523; -.
DR PRO; PR:P08523; -.
DR Proteomes; UP000002494; Chromosome 1.
DR GO; GO:0030424; C:axon; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; IDA:CAFA.
DR GO; GO:0005829; C:cytosol; ISO:RGD.
DR GO; GO:0043025; C:neuronal cell body; IDA:CAFA.
DR GO; GO:0005634; C:nucleus; IDA:CAFA.
DR GO; GO:0042277; F:peptide binding; IDA:RGD.
DR GO; GO:0022008; P:neurogenesis; ISO:RGD.
DR GO; GO:0007608; P:sensory perception of smell; ISO:RGD.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR DisProt; DP00279; -.
DR Gene3D; 2.60.120.390; -; 1.
DR InterPro; IPR009103; Olfactory_marker.
DR InterPro; IPR036727; Olfactory_marker_sf.
DR PANTHER; PTHR15357; PTHR15357; 1.
DR Pfam; PF06554; Olfactory_mark; 1.
DR SUPFAM; SSF63697; SSF63697; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Direct protein sequencing; Olfaction;
KW Reference proteome; Sensory transduction.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:3753006"
FT CHAIN 2..163
FT /note="Olfactory marker protein"
FT /id="PRO_0000058046"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000269|PubMed:3753006"
FT STRAND 4..8
FT /evidence="ECO:0007829|PDB:1JYT"
FT HELIX 19..33
FT /evidence="ECO:0007829|PDB:1JYT"
FT TURN 36..38
FT /evidence="ECO:0007829|PDB:1JYT"
FT STRAND 53..56
FT /evidence="ECO:0007829|PDB:1JYT"
FT STRAND 59..62
FT /evidence="ECO:0007829|PDB:1ZRI"
FT STRAND 69..71
FT /evidence="ECO:0007829|PDB:1JYT"
FT STRAND 73..81
FT /evidence="ECO:0007829|PDB:1JYT"
FT TURN 89..91
FT /evidence="ECO:0007829|PDB:1JYT"
FT STRAND 97..99
FT /evidence="ECO:0007829|PDB:1JYT"
FT STRAND 103..109
FT /evidence="ECO:0007829|PDB:1JYT"
FT TURN 110..112
FT /evidence="ECO:0007829|PDB:1JYT"
FT STRAND 113..118
FT /evidence="ECO:0007829|PDB:1JYT"
FT HELIX 119..134
FT /evidence="ECO:0007829|PDB:1JYT"
FT STRAND 138..144
FT /evidence="ECO:0007829|PDB:1JYT"
FT STRAND 155..157
FT /evidence="ECO:0007829|PDB:1JYT"
SQ SEQUENCE 163 AA; 18853 MW; 3E04155D1154199E CRC64;
MAEDGPQKQQ LDMPLVLDQD LTKQMRLRVE SLKQRGEKKQ DGEKLLRPAE SVYRLDFIQQ
QKLQFDHWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL DPAAIFWRKE DSDAMDWNEA
DALEFGERLS DLAKIRKVMY FLITFGEGVE PANLKASVVF NQL
