ARV1_ARATH
ID ARV1_ARATH Reviewed; 245 AA.
AC Q5MK24; Q0WRA1; Q9MAN2;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Protein ARV 1 {ECO:0000303|PubMed:16725371};
DE Short=AtArv1p {ECO:0000303|PubMed:16725371};
GN Name=ARV1 {ECO:0000303|PubMed:16725371};
GN OrderedLocusNames=At1g01020 {ECO:0000312|Araport:AT1G01020};
GN ORFNames=T25K16.2 {ECO:0000312|EMBL:AAF26477.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Col-3;
RX PubMed=16725371; DOI=10.1016/j.bbalip.2006.03.025;
RA Fores O., Arro M., Pahissa A., Ferrero S., Germann M., Stukey J.,
RA McDonough V., Nickels J.T. Jr., Campos N., Ferrer A.;
RT "Arabidopsis thaliana expresses two functional isoforms of Arvp, a protein
RT involved in the regulation of cellular lipid homeostasis.";
RL Biochim. Biophys. Acta 1761:725-735(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediator of sterol homeostasis involved in sterol uptake,
CC trafficking and distribution into membranes. Regulates also the
CC sphingolipid metabolism. {ECO:0000269|PubMed:16725371}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:16725371}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5MK24-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5MK24-2; Sequence=VSP_060101;
CC -!- TISSUE SPECIFICITY: Restricted to tissues in which cells are actively
CC dividing or expanding. Mostly expressed in roots and flowers, and, to a
CC lower extent, in stems and leaves. {ECO:0000269|PubMed:16725371}.
CC -!- DEVELOPMENTAL STAGE: In floral tissues, expressed in pollen grains and
CC fertilized ovules until they develop into seeds, and, at low levels, in
CC the styles. Observed in germinating seedlings, and later confined to
CC shoot and root apical meristems. Accumulates in emerging leaves and in
CC the vascular tissue of adult leaves. {ECO:0000269|PubMed:16725371}.
CC -!- SIMILARITY: Belongs to the ARV1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF26477.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY758070; AAV92715.1; -; mRNA.
DR EMBL; AC007323; AAF26477.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE27217.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59419.1; -; Genomic_DNA.
DR EMBL; AK228414; BAF00348.1; -; mRNA.
DR RefSeq; NP_001318899.1; NM_001331239.1. [Q5MK24-1]
DR RefSeq; NP_001321776.1; NM_001331242.1. [Q5MK24-2]
DR AlphaFoldDB; Q5MK24; -.
DR STRING; 3702.AT1G01020.1; -.
DR PaxDb; Q5MK24; -.
DR PRIDE; Q5MK24; -.
DR ProteomicsDB; 193607; -. [Q5MK24-1]
DR DNASU; 839569; -.
DR EnsemblPlants; AT1G01020.1; AT1G01020.1; AT1G01020. [Q5MK24-1]
DR EnsemblPlants; AT1G01020.5; AT1G01020.5; AT1G01020. [Q5MK24-2]
DR GeneID; 839569; -.
DR Gramene; AT1G01020.1; AT1G01020.1; AT1G01020. [Q5MK24-1]
DR Gramene; AT1G01020.5; AT1G01020.5; AT1G01020. [Q5MK24-2]
DR KEGG; ath:AT1G01020; -.
DR Araport; AT1G01020; -.
DR TAIR; locus:2200940; AT1G01020.
DR eggNOG; KOG3134; Eukaryota.
DR HOGENOM; CLU_057366_1_0_1; -.
DR InParanoid; Q5MK24; -.
DR OMA; DFKLYWK; -.
DR OrthoDB; 1466379at2759; -.
DR PhylomeDB; Q5MK24; -.
DR PRO; PR:Q5MK24; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q5MK24; baseline and differential.
DR GO; GO:0032541; C:cortical endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0032366; P:intracellular sterol transport; IBA:GO_Central.
DR GO; GO:0097036; P:regulation of plasma membrane sterol distribution; IBA:GO_Central.
DR GO; GO:0006665; P:sphingolipid metabolic process; IMP:TAIR.
DR GO; GO:0016125; P:sterol metabolic process; IMP:TAIR.
DR InterPro; IPR007290; Arv1.
DR PANTHER; PTHR14467; PTHR14467; 1.
DR Pfam; PF04161; Arv1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Endoplasmic reticulum; Lipid metabolism;
KW Lipid transport; Membrane; Reference proteome; Sphingolipid metabolism;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..245
FT /note="Protein ARV 1"
FT /id="PRO_0000446891"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..47
FT /note="Missing (in isoform 2)"
FT /id="VSP_060101"
SQ SEQUENCE 245 AA; 28092 MW; 3DC7A60903323470 CRC64;
MAASEHRCVG CGFRVKSLFI QYSPGNIRLM KCGNCKEVAD EYIECERMII FIDLILHRPK
VYRHVLYNAI NPATVNIQHL LWKLVFAYLL LDCYRSLLLR KSDEESSFSD SPVLLSIKVL
IGVLSANAAF IISFAIATKG LLNEVSRRRE IMLGIFISSY FKIFLLAMLV WEFPMSVIFF
VDILLLTSNS MALKVMTEST MTRCIAVCLI AHLIRFLVGQ IFEPTIFLIQ IGSLLQYMSY
FFRIV