ID   ARV1_ASHGO              Reviewed;         299 AA.
AC   Q750Q7;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Protein ARV1;
GN   Name=ARV1; OrderedLocusNames=AGL115W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Mediator of sterol homeostasis involved in sterol uptake,
CC       trafficking and distribution into membranes. Regulates also the
CC       sphingolipid metabolism (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARV1 family. {ECO:0000305}.
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DR   EMBL; AE016820; AAS54376.1; -; Genomic_DNA.
DR   RefSeq; NP_986552.1; NM_211614.1.
DR   AlphaFoldDB; Q750Q7; -.
DR   STRING; 33169.AAS54376; -.
DR   EnsemblFungi; AAS54376; AAS54376; AGOS_AGL115W.
DR   GeneID; 4622851; -.
DR   KEGG; ago:AGOS_AGL115W; -.
DR   eggNOG; KOG3134; Eukaryota.
DR   HOGENOM; CLU_057366_2_0_1; -.
DR   InParanoid; Q750Q7; -.
DR   OMA; KITICDS; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0032541; C:cortical endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032366; P:intracellular sterol transport; IBA:GO_Central.
DR   GO; GO:0097036; P:regulation of plasma membrane sterol distribution; IBA:GO_Central.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IBA:GO_Central.
DR   GO; GO:0016125; P:sterol metabolic process; IBA:GO_Central.
DR   InterPro; IPR007290; Arv1.
DR   PANTHER; PTHR14467; PTHR14467; 1.
DR   Pfam; PF04161; Arv1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Lipid metabolism;
KW   Lipid transport; Membrane; Reference proteome; Sphingolipid metabolism;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..299
FT                   /note="Protein ARV1"
FT                   /id="PRO_0000228134"
FT   TRANSMEM        99..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        176
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   299 AA;  35690 MW;  735DFD4E28017B2E CRC64;
     MICINCCCHV ESLYVAYPGD HIRLTDCWQC GEVVDRYVEF DNVLLFIDLL LLKPGAYRHL
     VYNSLEVDMR RYPEHGTRES GFRGYVQDWL LWFRKYDRLN RIWLLLITFE VYLMWMTEEK
     KYNNYYREPA TQYGWHLLTG DVLSLQNPLL QYLFFAVYVI GDLALLHKLT RESLLNWSQW
     GQDLRYAKDI VSYTILLSYG AKIFPILMLI WPYDSLVSTS IIKWIANFYI VESLRIVTSK
     SYSYIILLFA GIFIVRSVVL KPVLALIVSR GNMLQAQRYL WGEYELFKFR FLTKRDIFL