ID   OMT3_DICDI              Reviewed;         437 AA.
AC   Q8T199; Q554Q6;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=O-methyltransferase 3;
GN   Name=omt3; ORFNames=DDB_G0274197;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   INDUCTION [LARGE SCALE ANALYSIS].
RX   PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA   Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA   Skelton J., Ivens A., Bozzaro S.;
RT   "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT   bacteria in Dictyostelium.";
RL   BMC Genomics 9:291-291(2008).
CC   -!- FUNCTION: Probable methyltransferase. {ECO:0000250}.
CC   -!- INDUCTION: Up-regulated by phagocytic stimuli.
CC       {ECO:0000269|PubMed:18559084}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000012; EAL69991.1; -; Genomic_DNA.
DR   RefSeq; XP_644267.1; XM_639175.1.
DR   AlphaFoldDB; Q8T199; -.
DR   SMR; Q8T199; -.
DR   STRING; 44689.DDB0266731; -.
DR   PaxDb; Q8T199; -.
DR   EnsemblProtists; EAL69991; EAL69991; DDB_G0274197.
DR   GeneID; 8619695; -.
DR   KEGG; ddi:DDB_G0274197; -.
DR   dictyBase; DDB_G0274197; omt3.
DR   eggNOG; KOG2361; Eukaryota.
DR   HOGENOM; CLU_029724_0_2_1; -.
DR   InParanoid; Q8T199; -.
DR   OMA; CCLSENF; -.
DR   PhylomeDB; Q8T199; -.
DR   PRO; PR:Q8T199; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0001510; P:RNA methylation; IEA:UniProt.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR026113; MeTrfase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR22809; PTHR22809; 1.
DR   PIRSF; PIRSF037755; Mettl2_prd; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Methyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..437
FT                   /note="O-methyltransferase 3"
FT                   /id="PRO_0000377490"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          408..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          146..180
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   437 AA;  50464 MW;  28DF211492168F92 CRC64;
     MNNKTSNGDI TNDEPTVGSK RSWTDVNYKF CEDKEKQVVE EIQTETSWAD VDWDSVRESI
     AKSITEKETD IIGEEDKIHH EDNAMDYWDK FYKKNQNKFF KDRTYLHLEF PELNPLKITR
     DETFIFFEDD DAAAEGAENG GGGGGSDNLY QDKDDLEKQE KEREKKMANL LSKNVDIKEL
     KNRWVKDIQE LTNDESKKLT VLEIGCGTGA TVYPLLKLNP EKYFYVFDFS PHAVNLVKSN
     SLYNEAKLNA FVCDIATEQI PTSIVKDNSI DMMLMIFVLS AISRDKMHAV ANSLFKSLKP
     GGVLYIRDYG LYDMTQLRFI SKKGKKIDEN FYLRADGTRT YFFTTQVLSE IFEAAGFKTL
     VSKYDTRELR NRKRMISMYR VWVRGKFMKP LDNENTENNS KILSIYNDPI NNNNNNNNNN
     NNNNNNTTTT TSTTTTN