ID   ARV1_BOVIN              Reviewed;         282 AA.
AC   Q3SZW3;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Protein ARV1;
GN   Name=ARV1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role as a mediator in the endoplasmic reticulum (ER)
CC       cholesterol and bile acid homeostasis. Participates in sterol transport
CC       out of the ER and distribution into plasma membranes.
CC       {ECO:0000250|UniProtKB:Q9H2C2}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9H2C2}; Multi-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ARV1 family. {ECO:0000305}.
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DR   EMBL; BC102679; AAI02680.1; -; mRNA.
DR   RefSeq; NP_001030379.1; NM_001035302.2.
DR   AlphaFoldDB; Q3SZW3; -.
DR   STRING; 9913.ENSBTAP00000029091; -.
DR   PaxDb; Q3SZW3; -.
DR   GeneID; 515046; -.
DR   KEGG; bta:515046; -.
DR   CTD; 64801; -.
DR   eggNOG; KOG3134; Eukaryota.
DR   InParanoid; Q3SZW3; -.
DR   OrthoDB; 1466379at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0032366; P:intracellular sterol transport; IEA:InterPro.
DR   GO; GO:0090181; P:regulation of cholesterol metabolic process; ISS:UniProtKB.
DR   GO; GO:0032383; P:regulation of intracellular cholesterol transport; ISS:UniProtKB.
DR   InterPro; IPR007290; Arv1.
DR   PANTHER; PTHR14467; PTHR14467; 1.
DR   Pfam; PF04161; Arv1; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol metabolism; Endoplasmic reticulum; Lipid metabolism;
KW   Lipid transport; Membrane; Reference proteome; Steroid metabolism;
KW   Sterol metabolism; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..282
FT                   /note="Protein ARV1"
FT                   /id="PRO_0000228658"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   282 AA;  32435 MW;  0BF3247AC5B5B2B0 CRC64;
     MGTGGQNGLR PGKGNTEGVK EGKGKTDEVT MTSNTDASAS CQYRCIECNQ EAKELYRDYN
     HGVLKITICK SCQKPVDKYI EYDPVIILIN AILCKAQAYR HILFNTKINM HGKLCVFCLL
     CEAYLRWWQL QDSSQSIDPD DFIRYAKEWD FYRMFAIASL EQTAYFIGIF AFLWVERPIR
     AKEKLNFTLL LKALLLSSYG KLLLIPAVIW EHDYTPLCLR LIKVFVLTSN FQAIRVTLNI
     NRKLAFLAIL SGLLVESTMV YFFQRMEWAV GSDCAIYKSQ DF