ARV1_CANAL
ID ARV1_CANAL Reviewed; 296 AA.
AC Q5ANH2; A0A1D8PK62;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Protein ARV1;
GN Name=ARV1; OrderedLocusNames=CAALFM_C304710WA;
GN ORFNames=CaO19.13352, CaO19.5931;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22142782; DOI=10.1016/j.fgb.2011.11.006;
RA Gallo-Ebert C., McCourt P.C., Donigan M., Villasmil M.L., Chen W.,
RA Pandya D., Franco J., Romano D., Chadwick S.G., Gygax S.E.,
RA Nickels J.T. Jr.;
RT "Arv1 lipid transporter function is conserved between pathogenic and
RT nonpathogenic fungi.";
RL Fungal Genet. Biol. 49:101-113(2012).
CC -!- FUNCTION: Mediator of sterol homeostasis involved in sterol uptake,
CC trafficking and distribution into membranes. Regulates also the
CC sphingolipid metabolism. Required for growth during anaerobiosis and
CC sterol uptake. Plays a role in pathogenesis.
CC {ECO:0000269|PubMed:22142782}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Leads to avirulence using a BALB/c disseminated
CC mouse model. {ECO:0000269|PubMed:22142782}.
CC -!- SIMILARITY: Belongs to the ARV1 family. {ECO:0000305}.
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DR EMBL; CP017625; AOW28488.1; -; Genomic_DNA.
DR RefSeq; XP_723143.1; XM_718050.1.
DR AlphaFoldDB; Q5ANH2; -.
DR STRING; 237561.Q5ANH2; -.
DR GeneID; 3635248; -.
DR KEGG; cal:CAALFM_C304710WA; -.
DR CGD; CAL0000182745; ARV1.
DR VEuPathDB; FungiDB:C3_04710W_A; -.
DR eggNOG; KOG3134; Eukaryota.
DR HOGENOM; CLU_057366_2_0_1; -.
DR InParanoid; Q5ANH2; -.
DR OMA; KITICDS; -.
DR OrthoDB; 1466379at2759; -.
DR PHI-base; PHI:6660; -.
DR PRO; PR:Q5ANH2; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0032541; C:cortical endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0032366; P:intracellular sterol transport; IBA:GO_Central.
DR GO; GO:0097036; P:regulation of plasma membrane sterol distribution; IBA:GO_Central.
DR GO; GO:0006665; P:sphingolipid metabolic process; IBA:GO_Central.
DR GO; GO:0016125; P:sterol metabolic process; IBA:GO_Central.
DR InterPro; IPR007290; Arv1.
DR PANTHER; PTHR14467; PTHR14467; 1.
DR Pfam; PF04161; Arv1; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Lipid metabolism;
KW Lipid transport; Membrane; Reference proteome; Sphingolipid metabolism;
KW Transmembrane; Transmembrane helix; Transport; Virulence.
FT CHAIN 1..296
FT /note="Protein ARV1"
FT /id="PRO_0000422797"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 64
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 273
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 296 AA; 34878 MW; 68CFD154EB990ED2 CRC64;
MICIECGYSN IDCLYSKYKS DYIKLSVCPE CNKIADKYIE YDSVILFLDI LLLKRQAYKH
LAYNLTEMEM EIGSSTNFHI NDNTNFKFFH TYRKLMKLIF MILSFEVYLT WANEEKLLIH
SQLINLIFNQ SVVYQYLFFI IKSSLENLIL NLSLQLILRL GYKWGQGPQK INGNIRDKEL
FGYKTSVLLV TTMVSGSIRL FPILMFIWPY DNISITKPLI NLIAFINIVE ALRVVTSLGY
VELILSLAFS IVIRNIVSKS LLVLIVRLFL DFNFTEVYYN EMYQLYSQIQ TYIRWI
