ONCO_HUMAN
ID ONCO_HUMAN Reviewed; 109 AA.
AC P0CE72; B9EJH7; P32930; Q6ISI5; Q75MW0;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Oncomodulin-1;
DE Short=OM;
DE AltName: Full=Parvalbumin beta;
GN Name=OCM; Synonyms=OCM1, OCMN;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Placenta;
RX PubMed=8354278; DOI=10.1111/j.1432-1033.1993.tb18084.x;
RA Foehr U.G., Weber B.R., Muentener M., Staudenmann W., Hughes G.J.,
RA Frutiger S., Banville D., Schaefer B.W., Heizmann C.W.;
RT "Human alpha and beta parvalbumins. Structure and tissue-specific
RT expression.";
RL Eur. J. Biochem. 215:719-727(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP STRUCTURE BY NMR, AND CALCIUM-BINDING SITES.
RX PubMed=15610002; DOI=10.1021/bi048388o;
RA Babini E., Bertini I., Capozzi F., Del Bianco C., Hollender D., Kiss T.,
RA Luchinat C., Quattrone A.;
RT "Solution structure of human beta-parvalbumin and structural comparison
RT with its paralog alpha-parvalbumin and with their rat orthologs.";
RL Biochemistry 43:16076-16085(2004).
CC -!- FUNCTION: Has some calmodulin-like activity with respect to enzyme
CC activation and growth regulation. Binds two calcium ions.
CC -!- INTERACTION:
CC P0CE72; P12532: CKMT1B; NbExp=6; IntAct=EBI-11955379, EBI-1050662;
CC P0CE72; O00560: SDCBP; NbExp=3; IntAct=EBI-11955379, EBI-727004;
CC -!- SIMILARITY: Belongs to the parvalbumin family. {ECO:0000305}.
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DR EMBL; L20348; AAA02869.1; -; Genomic_DNA.
DR EMBL; L20345; AAA02869.1; JOINED; Genomic_DNA.
DR EMBL; L20346; AAA02869.1; JOINED; Genomic_DNA.
DR EMBL; L20347; AAA02869.1; JOINED; Genomic_DNA.
DR EMBL; AC004983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471144; EAW87352.1; -; Genomic_DNA.
DR EMBL; BC069468; AAH69468.1; -; mRNA.
DR EMBL; BC069512; AAH69512.1; -; mRNA.
DR EMBL; BC069550; AAH69550.1; -; mRNA.
DR EMBL; BC113706; AAI13707.1; -; mRNA.
DR EMBL; BC113704; AAI13705.1; -; mRNA.
DR EMBL; BC147028; AAI47029.1; -; mRNA.
DR EMBL; BC147029; AAI47030.1; -; mRNA.
DR CCDS; CCDS43548.1; -.
DR PIR; S35041; PVHUO.
DR RefSeq; NP_001091091.1; NM_001097622.1.
DR RefSeq; XP_011513787.1; XM_011515485.2.
DR PDB; 1TTX; NMR; -; A=1-109.
DR PDBsum; 1TTX; -.
DR AlphaFoldDB; P0CE72; -.
DR BMRB; P0CE72; -.
DR SMR; P0CE72; -.
DR BioGRID; 576309; 5.
DR IntAct; P0CE72; 2.
DR STRING; 9606.ENSP00000242104; -.
DR iPTMnet; P0CE72; -.
DR PhosphoSitePlus; P0CE72; -.
DR BioMuta; OCM; -.
DR DMDM; 292630843; -.
DR MassIVE; P0CE72; -.
DR PaxDb; P0CE72; -.
DR PeptideAtlas; P0CE72; -.
DR PRIDE; P0CE72; -.
DR Antibodypedia; 64205; 70 antibodies from 10 providers.
DR DNASU; 654231; -.
DR Ensembl; ENST00000242104.6; ENSP00000242104.5; ENSG00000122543.11.
DR Ensembl; ENST00000416608.5; ENSP00000401365.1; ENSG00000122543.11.
DR GeneID; 654231; -.
DR KEGG; hsa:654231; -.
DR MANE-Select; ENST00000242104.6; ENSP00000242104.5; NM_001097622.2; NP_001091091.1.
DR UCSC; uc003spe.5; human.
DR CTD; 654231; -.
DR DisGeNET; 654231; -.
DR GeneCards; OCM; -.
DR HGNC; HGNC:8105; OCM.
DR HPA; ENSG00000122543; Tissue enhanced (brain).
DR MIM; 164795; gene.
DR neXtProt; NX_P0CE72; -.
DR OpenTargets; ENSG00000122543; -.
DR PharmGKB; PA31894; -.
DR VEuPathDB; HostDB:ENSG00000122543; -.
DR eggNOG; KOG0027; Eukaryota.
DR GeneTree; ENSGT00940000161875; -.
DR HOGENOM; CLU_157356_0_0_1; -.
DR InParanoid; P0CE72; -.
DR OMA; PTICWIL; -.
DR OrthoDB; 1524081at2759; -.
DR PhylomeDB; P0CE72; -.
DR TreeFam; TF332342; -.
DR PathwayCommons; P0CE72; -.
DR SignaLink; P0CE72; -.
DR BioGRID-ORCS; 654231; 18 hits in 983 CRISPR screens.
DR ChiTaRS; OCM; human.
DR EvolutionaryTrace; P0CE72; -.
DR GenomeRNAi; 654231; -.
DR Pharos; P0CE72; Tbio.
DR PRO; PR:P0CE72; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P0CE72; protein.
DR Bgee; ENSG00000122543; Expressed in amygdala and 87 other tissues.
DR Genevisible; P0CE72; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR008080; Parvalbumin.
DR PANTHER; PTHR11653; PTHR11653; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Calcium; Metal-binding; Reference proteome;
KW Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P02631"
FT CHAIN 2..109
FT /note="Oncomodulin-1"
FT /id="PRO_0000073582"
FT DOMAIN 39..74
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 78..109
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 52
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448,
FT ECO:0000269|PubMed:15610002, ECO:0007744|PDB:1TTX"
FT BINDING 54
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 56
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448,
FT ECO:0000269|PubMed:15610002, ECO:0007744|PDB:1TTX"
FT BINDING 58
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448,
FT ECO:0000269|PubMed:15610002, ECO:0007744|PDB:1TTX"
FT BINDING 63
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448,
FT ECO:0000269|PubMed:15610002, ECO:0007744|PDB:1TTX"
FT BINDING 91
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448,
FT ECO:0000269|PubMed:15610002, ECO:0007744|PDB:1TTX"
FT BINDING 93
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448,
FT ECO:0000269|PubMed:15610002, ECO:0007744|PDB:1TTX"
FT BINDING 95
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448,
FT ECO:0000269|PubMed:15610002, ECO:0007744|PDB:1TTX"
FT BINDING 97
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448,
FT ECO:0000269|PubMed:15610002, ECO:0007744|PDB:1TTX"
FT BINDING 102
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448,
FT ECO:0000269|PubMed:15610002, ECO:0007744|PDB:1TTX"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:P02631"
FT CONFLICT 20
FT /note="R -> Q (in Ref. 1; AAA02869)"
FT /evidence="ECO:0000305"
FT TURN 4..6
FT /evidence="ECO:0007829|PDB:1TTX"
FT HELIX 8..18
FT /evidence="ECO:0007829|PDB:1TTX"
FT HELIX 27..33
FT /evidence="ECO:0007829|PDB:1TTX"
FT TURN 36..38
FT /evidence="ECO:0007829|PDB:1TTX"
FT HELIX 41..51
FT /evidence="ECO:0007829|PDB:1TTX"
FT STRAND 56..58
FT /evidence="ECO:0007829|PDB:1TTX"
FT HELIX 61..64
FT /evidence="ECO:0007829|PDB:1TTX"
FT HELIX 68..70
FT /evidence="ECO:0007829|PDB:1TTX"
FT HELIX 80..90
FT /evidence="ECO:0007829|PDB:1TTX"
FT STRAND 92..96
FT /evidence="ECO:0007829|PDB:1TTX"
FT HELIX 100..108
FT /evidence="ECO:0007829|PDB:1TTX"
SQ SEQUENCE 109 AA; 12184 MW; C5793E2FF4A058A0 CRC64;
MSITDVLSAD DIAAALQECR DPDTFEPQKF FQTSGLSKMS ANQVKDVFRF IDNDQSGYLD
EEELKFFLQK FESGARELTE SETKSLMAAA DNDGDGKIGA EEFQEMVHS
