ONEC2_HUMAN
ID ONEC2_HUMAN Reviewed; 504 AA.
AC O95948;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=One cut domain family member 2;
DE AltName: Full=Hepatocyte nuclear factor 6-beta;
DE Short=HNF-6-beta;
DE AltName: Full=One cut homeobox 2;
DE AltName: Full=Transcription factor ONECUT-2;
DE Short=OC-2;
GN Name=ONECUT2; Synonyms=HNF6B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9915796; DOI=10.1074/jbc.274.5.2665;
RA Jacquemin P., Lannoy V., Rousseau G.G., Lemaigre F.P.;
RT "OC-2, a novel mammalian member of the ONECUT class of homeodomain
RT transcription factors whose function in liver partially overlaps with that
RT of hepatocyte nuclear factor-6.";
RL J. Biol. Chem. 274:2665-2671(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
CC -!- FUNCTION: Transcriptional activator. Activates the transcription of a
CC number of liver genes such as HNF3B.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the CUT homeobox family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-20 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB38253.1; Type=Frameshift; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Wikipedia; Note=Hepatocyte nuclear factors entry;
CC URL="https://en.wikipedia.org/wiki/Hepatocyte_nuclear_factors";
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DR EMBL; Y18198; CAB38253.1; ALT_FRAME; mRNA.
DR EMBL; AC090340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS42440.1; -.
DR RefSeq; NP_004843.2; NM_004852.2.
DR AlphaFoldDB; O95948; -.
DR SMR; O95948; -.
DR BioGRID; 114865; 5.
DR STRING; 9606.ENSP00000419185; -.
DR iPTMnet; O95948; -.
DR PhosphoSitePlus; O95948; -.
DR BioMuta; ONECUT2; -.
DR jPOST; O95948; -.
DR MassIVE; O95948; -.
DR PaxDb; O95948; -.
DR PeptideAtlas; O95948; -.
DR PRIDE; O95948; -.
DR ProteomicsDB; 51141; -.
DR TopDownProteomics; O95948; -.
DR Antibodypedia; 5415; 155 antibodies from 23 providers.
DR DNASU; 9480; -.
DR Ensembl; ENST00000491143.3; ENSP00000419185.2; ENSG00000119547.6.
DR GeneID; 9480; -.
DR KEGG; hsa:9480; -.
DR MANE-Select; ENST00000491143.3; ENSP00000419185.2; NM_004852.3; NP_004843.2.
DR UCSC; uc002lgo.4; human.
DR CTD; 9480; -.
DR DisGeNET; 9480; -.
DR GeneCards; ONECUT2; -.
DR HGNC; HGNC:8139; ONECUT2.
DR HPA; ENSG00000119547; Tissue enhanced (brain, gallbladder, intestine, liver, retina).
DR MIM; 604894; gene.
DR neXtProt; NX_O95948; -.
DR OpenTargets; ENSG00000119547; -.
DR PharmGKB; PA31925; -.
DR VEuPathDB; HostDB:ENSG00000119547; -.
DR eggNOG; KOG2252; Eukaryota.
DR GeneTree; ENSGT00950000183103; -.
DR HOGENOM; CLU_018642_0_0_1; -.
DR InParanoid; O95948; -.
DR OMA; YKDHMSG; -.
DR OrthoDB; 709082at2759; -.
DR PhylomeDB; O95948; -.
DR TreeFam; TF318206; -.
DR PathwayCommons; O95948; -.
DR SignaLink; O95948; -.
DR BioGRID-ORCS; 9480; 11 hits in 1095 CRISPR screens.
DR ChiTaRS; ONECUT2; human.
DR GenomeRNAi; 9480; -.
DR Pharos; O95948; Tbio.
DR PRO; PR:O95948; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; O95948; protein.
DR Bgee; ENSG00000119547; Expressed in jejunal mucosa and 65 other tissues.
DR Genevisible; O95948; HS.
DR GO; GO:0015629; C:actin cytoskeleton; IDA:HPA.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0009887; P:animal organ morphogenesis; TAS:ProtInc.
DR GO; GO:0045165; P:cell fate commitment; IEA:Ensembl.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0031018; P:endocrine pancreas development; IEA:Ensembl.
DR GO; GO:0002064; P:epithelial cell development; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:1905319; P:mesenchymal stem cell migration; IEA:Ensembl.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0048935; P:peripheral nervous system neuron development; IEA:Ensembl.
DR GO; GO:1905322; P:positive regulation of mesenchymal stem cell migration; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0001952; P:regulation of cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR003350; CUT_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR Pfam; PF02376; CUT; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM01109; CUT; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS51042; CUT; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..504
FT /note="One cut domain family member 2"
FT /id="PRO_0000202405"
FT DNA_BIND 324..410
FT /note="CUT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00374"
FT DNA_BIND 426..485
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 29..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..187
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 17
FT /note="G -> R (in Ref. 1; CAB38253)"
FT /evidence="ECO:0000305"
FT CONFLICT 35..36
FT /note="PA -> AR (in Ref. 1; CAB38253)"
FT /evidence="ECO:0000305"
FT CONFLICT 71
FT /note="G -> R (in Ref. 1; CAB38253)"
FT /evidence="ECO:0000305"
FT CONFLICT 74..75
FT /note="AA -> PR (in Ref. 1; CAB38253)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 504 AA; 54303 MW; 09762F3C8BD6DD6B CRC64;
MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPAGGGS GGGGGGGGGG GGGGPGHEQE
LLASPSPHHA GRGAAGSLRG PPPPPTAHQE LGTAAAAAAA ASRSAMVTSM ASILDGGDYR
PELSIPLHHA MSMSCDSSPP GMGMSNTYTT LTPLQPLPPI STVSDKFHHP HPHHHPHHHH
HHHHQRLSGN VSGSFTLMRD ERGLPAMNNL YSPYKEMPGM SQSLSPLAAT PLGNGLGGLH
NAQQSLPNYG PPGHDKMLSP NFDAHHTAML TRGEQHLSRG LGTPPAAMMS HLNGLHHPGH
TQSHGPVLAP SRERPPSSSS GSQVATSGQL EEINTKEVAQ RITAELKRYS IPQAIFAQRV
LCRSQGTLSD LLRNPKPWSK LKSGRETFRR MWKWLQEPEF QRMSALRLAA CKRKEQEPNK
DRNNSQKKSR LVFTDLQRRT LFAIFKENKR PSKEMQITIS QQLGLELTTV SNFFMNARRR
SLEKWQDDLS TGGSSSTSST CTKA
