ONEC2_MOUSE
ID ONEC2_MOUSE Reviewed; 505 AA.
AC Q6XBJ3;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=One cut domain family member 2;
DE AltName: Full=One cut homeobox 2;
DE AltName: Full=Transcription factor ONECUT-2;
DE Short=OC-2;
GN Name=Onecut2; Synonyms=Oc2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6 X CBA;
RX PubMed=12971999; DOI=10.1016/s1567-133x(03)00110-8;
RA Jacquemin P., Pierreux C.E., Fierens S., van Eyll J.M., Lemaigre F.P.,
RA Rousseau G.G.;
RT "Cloning and embryonic expression pattern of the mouse Onecut transcription
RT factor OC-2.";
RL Gene Expr. Patterns 3:639-644(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Transcriptional activator. Activates the transcription of a
CC number of liver genes such as HNF3B (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the CUT homeobox family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-20 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP69907.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY242995; AAP69907.1; ALT_INIT; mRNA.
DR EMBL; AC102106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS29302.2; -.
DR RefSeq; NP_919244.2; NM_194268.2.
DR AlphaFoldDB; Q6XBJ3; -.
DR SMR; Q6XBJ3; -.
DR BioGRID; 230411; 1.
DR STRING; 10090.ENSMUSP00000110798; -.
DR PhosphoSitePlus; Q6XBJ3; -.
DR jPOST; Q6XBJ3; -.
DR MaxQB; Q6XBJ3; -.
DR PaxDb; Q6XBJ3; -.
DR PRIDE; Q6XBJ3; -.
DR ProteomicsDB; 289990; -.
DR Antibodypedia; 5415; 155 antibodies from 23 providers.
DR DNASU; 225631; -.
DR Ensembl; ENSMUST00000175965; ENSMUSP00000135692; ENSMUSG00000045991.
DR GeneID; 225631; -.
DR KEGG; mmu:225631; -.
DR UCSC; uc008fef.1; mouse.
DR CTD; 9480; -.
DR MGI; MGI:1891408; Onecut2.
DR VEuPathDB; HostDB:ENSMUSG00000045991; -.
DR eggNOG; KOG2252; Eukaryota.
DR GeneTree; ENSGT00950000183103; -.
DR InParanoid; Q6XBJ3; -.
DR OMA; YKDHMSG; -.
DR OrthoDB; 709082at2759; -.
DR PhylomeDB; Q6XBJ3; -.
DR TreeFam; TF318206; -.
DR BioGRID-ORCS; 225631; 5 hits in 75 CRISPR screens.
DR ChiTaRS; Onecut2; mouse.
DR PRO; PR:Q6XBJ3; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q6XBJ3; protein.
DR Bgee; ENSMUSG00000045991; Expressed in lumbar dorsal root ganglion and 103 other tissues.
DR Genevisible; Q6XBJ3; MM.
DR GO; GO:0015629; C:actin cytoskeleton; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IMP:MGI.
DR GO; GO:0045165; P:cell fate commitment; IGI:MGI.
DR GO; GO:0016477; P:cell migration; IGI:MGI.
DR GO; GO:0060271; P:cilium assembly; IMP:MGI.
DR GO; GO:0031018; P:endocrine pancreas development; IGI:MGI.
DR GO; GO:0002064; P:epithelial cell development; IMP:MGI.
DR GO; GO:0001889; P:liver development; IGI:MGI.
DR GO; GO:1905319; P:mesenchymal stem cell migration; IGI:MGI.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IGI:MGI.
DR GO; GO:0031016; P:pancreas development; IGI:MGI.
DR GO; GO:0048935; P:peripheral nervous system neuron development; IMP:MGI.
DR GO; GO:1905322; P:positive regulation of mesenchymal stem cell migration; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0001952; P:regulation of cell-matrix adhesion; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IGI:MGI.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR003350; CUT_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR Pfam; PF02376; CUT; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM01109; CUT; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS51042; CUT; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..505
FT /note="One cut domain family member 2"
FT /id="PRO_0000202406"
FT DNA_BIND 325..411
FT /note="CUT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00374"
FT DNA_BIND 427..486
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 29..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..188
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 151
FT /note="T -> A (in Ref. 1; AAP69907)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 505 AA; 54554 MW; EACECA422CDCB1A3 CRC64;
MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPVGGGS GGGGGGGGGG GGGGPGHEQE
LLASPSPHHA GRGAAGSLRG PPPPTAHQEL GTAAAAAAAA SRSAMVTSMA SILDGSDYRP
ELSIPLHHAM SMSCDSSPPG MGMSNTYTTL TPLQPLPPIS TVSDKFHHPH PHHHPHHHHH
HHHHHQRLSG NVSGSFTLMR DERGLPSMNN LYSPYKEMPS MSQSLSPLAA TPLGNGLGGL
HNAQQSLPNY GPPGHDKMLS PNFDAHHTAM LTRGEQHLSR GLGTPPAAMM SHLNGLHHPG
HTQSHGPVLA PSRERPPSSS SGSQVATSGQ LEEINTKEVA QRITAELKRY SIPQAIFAQR
VLCRSQGTLS DLLRNPKPWS KLKSGRETFR RMWKWLQEPE FQRMSALRLA ACKRKEQEPN
KDRNNSQKKS RLVFTDLQRR TLFAIFKENK RPSKEMQITI SQQLGLELTT VSNFFMNARR
RSLEKWQDDL GTGGSSSTSS TCTKA
