ONEC3_MOUSE
ID ONEC3_MOUSE Reviewed; 490 AA.
AC Q8K557; Q6PDH9;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=One cut domain family member 3;
DE AltName: Full=One cut homeobox 3;
DE AltName: Full=Transcription factor ONECUT-3;
DE Short=OC-3;
GN Name=Onecut3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=129/SvEvTacfBr;
RX PubMed=11944891; DOI=10.1006/bbrc.2002.6760;
RA Vanhorenbeeck V., Jacquemin P., Lemaigre F.P., Rousseau G.G.;
RT "OC-3, a novel mammalian member of the ONECUT class of transcription
RT factors.";
RL Biochem. Biophys. Res. Commun. 292:848-854(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP DEVELOPMENTAL STAGE, INDUCTION BY ONECUT1, AND SUBCELLULAR LOCATION.
RX PubMed=15381696; DOI=10.1074/jbc.m409038200;
RA Pierreux C.E., Vanhorenbeeck V., Jacquemin P., Lemaigre F.P.,
RA Rousseau G.G.;
RT "The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the
RT expression of its paralog Onecut-3 in developing mouse endoderm.";
RL J. Biol. Chem. 279:51298-51304(2004).
CC -!- FUNCTION: Transcriptional activator. Binds the consensus DNA sequence
CC 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of
CC HNF3B and TTR. {ECO:0000269|PubMed:11944891}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|PROSITE-ProRule:PRU00374, ECO:0000269|PubMed:15381696}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in brain, stomach and gut.
CC Within the gut, expressed only in duodenum and jejunum.
CC {ECO:0000269|PubMed:11944891}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the endoderm from the 14-somite
CC stage. Aroound 9.5 dpc, present in the ventral prepancreatic and
CC prehepatic regions (at protein level). At 14.5 dpc, expressed in brain,
CC stomach and gut. {ECO:0000269|PubMed:11944891,
CC ECO:0000269|PubMed:15381696}.
CC -!- INDUCTION: Transcriptionally regulated by ONECUT1 in the developing
CC endoderm. {ECO:0000269|PubMed:15381696}.
CC -!- SIMILARITY: Belongs to the CUT homeobox family. {ECO:0000305}.
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DR EMBL; AY080897; AAL86921.1; -; mRNA.
DR EMBL; BC058700; AAH58700.1; -; mRNA.
DR CCDS; CCDS24023.1; -.
DR RefSeq; NP_631972.2; NM_139226.3.
DR AlphaFoldDB; Q8K557; -.
DR SMR; Q8K557; -.
DR STRING; 10090.ENSMUSP00000053288; -.
DR PhosphoSitePlus; Q8K557; -.
DR MaxQB; Q8K557; -.
DR PaxDb; Q8K557; -.
DR PRIDE; Q8K557; -.
DR ProteomicsDB; 295471; -.
DR Antibodypedia; 5527; 148 antibodies from 19 providers.
DR DNASU; 246086; -.
DR Ensembl; ENSMUST00000051773; ENSMUSP00000053288; ENSMUSG00000045518.
DR GeneID; 246086; -.
DR KEGG; mmu:246086; -.
DR UCSC; uc007gdn.1; mouse.
DR CTD; 390874; -.
DR MGI; MGI:1891409; Onecut3.
DR VEuPathDB; HostDB:ENSMUSG00000045518; -.
DR eggNOG; KOG2252; Eukaryota.
DR GeneTree; ENSGT00950000183103; -.
DR HOGENOM; CLU_018642_0_0_1; -.
DR InParanoid; Q8K557; -.
DR OMA; WHDDHGA; -.
DR OrthoDB; 709082at2759; -.
DR PhylomeDB; Q8K557; -.
DR TreeFam; TF318206; -.
DR BioGRID-ORCS; 246086; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Onecut3; mouse.
DR PRO; PR:Q8K557; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8K557; protein.
DR Bgee; ENSMUSG00000045518; Expressed in ureteric bud trunk and 46 other tissues.
DR Genevisible; Q8K557; MM.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR003350; CUT_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR Pfam; PF02376; CUT; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM01109; CUT; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS51042; CUT; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..490
FT /note="One cut domain family member 3"
FT /id="PRO_0000271219"
FT DNA_BIND 309..395
FT /note="CUT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00374"
FT DNA_BIND 411..470
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 130..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..154
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..213
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 64
FT /note="A -> R (in Ref. 1; AAL86921)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 490 AA; 49571 MW; D9030944CED1BA06 CRC64;
MELSLESLGG LHGVTHAQAG ELLSPGHARS AAAQHRSLVA SGRPGLVAGM ASLLDGGGAG
GGGAGGAGAA GAAGGGPDFR GELAGPLHPA MGMACEAPGL GGTYTTLTPL QHLPPLAAVA
DKFHQHAVAG AHGGHPHAHP HPATAPPPPP PQRLAASVSG SFTLMRDERA ALASVGHLYG
PYGKELPTMG SPLSPLPSAL PPALHSAPQP PPPPPLAAYG APGHLAGDKL LPPAAFEPHA
ALLGRAEDAL ARGLPGGGGG AGGGGAAGGA AAGLLAPLGG LAAAGAHGPH SGGGGPGGGG
GAGGGSGGPG AGAAAEEINT KEVAQRITAE LKRYSIPQAI FAQRILCRSQ GTLSDLLRNP
KPWSKLKSGR ETFRRMWKWL QEPEFQRMSA LRLAACKRKE QDQQKERALQ PKKQRLVFTD
LQRRTLIAIF KENKRPSKEM QATISQQLGL ELNTVSNFFM NARRRCMNRW AEEPGATPGT
GTATATFSKA
